Preparation of uniform prednisolone microcrystals by a controlled microprecipitation method

Li, Xiang-Shan; Wang, Jie‐Xin; Shen, Zhigang; Zhang, Peng-Yuan; Chen, Jianfeng; Yun, Jimmy

doi:10.1016/j.ijpharm.2007.04.025

Cited by 65 publications

(30 citation statements)

References 24 publications

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“…Furthermore, to improve patient convenience and physical stability issues of NS, 12 it is usually preferable to transform liquid NS (LNS) into solid nanocrystals (SNS) via freeze-drying, spray-drying, or vacuum-spraying, and SNS can be redispersed into fine NS instantaneously with aqueous media in vitro or in the gastrointestinal tract. 13 Commonly, NS techniques are classified as bottom-up methods 14,15 or top-down methods, 16,17 according to the differences in production principle. High-pressure homogenization technology is a promising method for preparing NS.…”

Section: Introductionmentioning

confidence: 99%

Process optimization and evaluation of novel baicalin solid nanocrystals

Yue¹,

Liu²,

Wan³

et al. 2013

IJN

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Section: Introductionmentioning

confidence: 99%

Process optimization and evaluation of novel baicalin solid nanocrystals

Yue¹,

Liu²,

Wan³

et al. 2013

IJN

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“…The technique presents some advantages, in that it is a straightforward method, rapid and easy to perform. It has been successfully used to prepare several drugs, such as budesonide [20], danazol [21], beclomethasone dipropionate [18], prednisolone [22], atorvastatin [23], griseofulvin and fenofibrate [24].…”

Section: Introductionmentioning

confidence: 99%

An innovative antisolvent precipitation process as a promising technique to prepare ultrafine rifampicin particles

Viçosa¹,

Letourneau²,

Espitalier³

et al. 2012

Journal of Crystal Growth

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a b s t r a c tMany existing and new drugs fail to be fully utilized because of their limited bioavailability due to poor solubility in aqueous media (BCS drug classes II and IV). In this work, for accelerating dissolution of this kind of poorly water-soluble drugs, an antisolvent precipitation method that does not require the use of conventional volatile organic solvents is proposed. To demonstrate this technique, ultrafine particles of rifampicin were prepared using a room temperature ionic liquid (1-ethyl 3-methyl imidazolium methyl-phosphonate) as an alternative solvent and a phosphate buffer as an antisolvent.Rifampicin solubility was measured in various solvents (1-ethyl 3-methyl imidazolium methylphosphonate, water and phosphate buffer), showing the RTIL good solvency for the model drug: rifampicin solubility was found to be higher than 90 mg/g in RTIL at 30 1C and lower than 1 mg/g in water at 25 1C. Additionally, it was demonstrated that introduction of rifampicin solution in 1-ethyl 3-methyl imidazolium methyl-phosphonate into the aqueous solution antisolvent can produce particles in the submicron range with or without hydroxypropyl methylcellulose as the stabilizer. The ultrafine particles (280-360 nm) are amorphous with enhanced solubility and faster dissolution rate. To our knowledge, this is the first published work examining the suitability of using RTILs for ultrafine drug nanoparticles preparation by an antisolvent precipitation process.

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“…According to the Kelvin equation, as the particle becomes progressively smaller, the surface tension and the molar free energy of product change, thereby resulting in the increased solubility [39]. Besides, It is well-known that the dissolution rate obeys the Nernst-Noyes-Whitney equation, the dissolution rate could be increased by reducing the particle size at the micro-or nano-scale to increase the specific surface area [40,41]. Therefore, as shown in Fig.…”

Section: Powder Characterizationmentioning

confidence: 99%