Preparation of thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres as anticancer drug carriers

Fan, Tengfei; Li, Mingjun; Wu, Xuemin; Li, Min; Wu, Yan

doi:10.1016/j.colsurfb.2011.07.048

Cited by 89 publications

(77 citation statements)

References 41 publications

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“…The elimination of nitrate favors the formation of the iron complex (reaction 1), thereby, the precursor is completely transformed into the iron complex. According to Miguel-Sancho et al [25], there was no gas emission before 180°C when the precursor was Fe(acac) 3 , thus the formation of the iron complex, in samples CM, is limited by the equilibrium in reaction 1. From the previous discussion, at the same initial Fe 3+ concentration, the amount of iron complex in samples MM is higher than the corresponding one to samples CM, whatever the type of iron complex produced in reaction 1.…”

Section: ( ) mentioning

confidence: 99%

“…Water-dispersible magnetite nanoparticles were prepared by the thermal decomposition of Fe(acac) 3 or Fe(NO 3 ) 3 .9H 2 O in TEG at 280°C according to Cai and Wan [20].…”

Section: Preparation Of Magnetite Nanoparticlesmentioning

confidence: 99%

“…In a more recent paper, Miguel-Sancho et al [25] showed the influence of some experimental parameters on particle size, as initial precursor concentration, decomposition time and heating rate. A particle formation mechanism of iron oxide nanoparticles was proposed, which could be controlled by the total Fe(acac) 3 concentration and the type of solvent used, although crystallization conditions and magnetic properties were not discussed. Grabs et al [21] compared decomposition of Fe(acac) 3 in TEG and benzyl alcohol and evaluated how the reaction time affects the crystalline and magnetic properties, maintaining aconstantconcentration of the precursor.…”

Section: Introductionmentioning

confidence: 99%

“…A particle formation mechanism of iron oxide nanoparticles was proposed, which could be controlled by the total Fe(acac) 3 concentration and the type of solvent used, although crystallization conditions and magnetic properties were not discussed. Grabs et al [21] compared decomposition of Fe(acac) 3 in TEG and benzyl alcohol and evaluated how the reaction time affects the crystalline and magnetic properties, maintaining aconstantconcentration of the precursor. Jiang et al [27] modified the method using ferric nitrate as precursor salt, obtaining very small iron oxide nanoparticle, however the influence of the initial concentration of the precursor salt and a comparative study with the conventional method were not reported.…”

Section: Introductionmentioning

confidence: 99%

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Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Vega-Chacón

Picasso

Avilés-Félix

et al. 2016

Adv. Nat. Sci: Nanosci. Nanotechnol.

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In this paper we present a modified polyol method for synthesizing magnetite nanoparticles using iron (III) nitrate, a low toxic and cheap precursor salt. The influence of the precursor salt nature and initial ferric concentration in the average particle size and magnetic properties of the obtained nanoparticles were investigated. Magnetite nanoparticles have received much attention due to the multiple uses in the biomedical field; for these purposes nanoparticles with monodisperse size distribution, superparamagnetic behavior and a combination between small average size and high saturation magnetization are required. The polyol conventional method allows synthesizing water-dispersible magnetite nanoparticles with these features employing iron (III) acetylacetonate as precursor salt. Although the particle sizes of samples synthesized from the conventional polyol method (denoted CM) are larger than those of samples synthesized from the modified method (denoted MM), they display similar saturation magnetization. The differences in the nanoparticles average sizes of samples CM and samples MM were explained though the known nanoparticle formation mechanism.

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Section: ( ) mentioning

confidence: 99%

“…Water-dispersible magnetite nanoparticles were prepared by the thermal decomposition of Fe(acac) 3 or Fe(NO 3 ) 3 .9H 2 O in TEG at 280°C according to Cai and Wan [20].…”

Section: Preparation Of Magnetite Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Vega-Chacón

Picasso

Avilés-Félix

et al. 2016

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…Hydrogels are polymers with a three-dimensional structure that exhibit the ability to swell in water and keep significant amount of water within the structures [8]. They can be divided into natural hydrogels and synthetic ones.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Hong

Chen

et al. 2014

Nano-Micro Lett

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Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms. In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology.

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Design and Control of the Magnetically Actuated Micro/Nanorobot Swarm toward Biomedical Applications

Lu,

Zhao,

et al. 2024

Adv Healthcare Materials

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Recently, magnetically actuated micro/nanorobots hold extensive promises in biomedical applications due to their advantages of non‐invasiveness, fuel‐free operation, and programmable nature. While effectively promised in various fields such as targeted delivery, most past investigations are mainly displayed in magnetic control of individual micro/nanorobots. Facing practical medical use, the micro/nanorobots are required for the development of swarm control in a closed‐loop control manner. This review outlines the recent developments in magnetic micro/nanorobot swarms, including their actuating fundamentals, designs, controls, and biomedical applications. The fundamental principles and interactions involved in the formation of magnetic micro/nanorobot swarms are discussed first. The recent advances in the design of artificial and biohybrid micro/nanorobot swarms, along with the control devices and methods used for swarm manipulation, are presented. Furthermore, biomedical applications that have the potential to achieve clinical application are introduced, such as imaging‐guided therapy, targeted delivery, embolization, and biofilm eradication. By addressing the potential challenges discussed towards the end of this review, magnetic micro/nanorobot swarms hold promise for clinical treatments in the future.This article is protected by copyright. All rights reserved

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Preparation of thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres as anticancer drug carriers

Cited by 89 publications

References 41 publications

Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Design and Control of the Magnetically Actuated Micro/Nanorobot Swarm toward Biomedical Applications

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