Influence of synthesis experimental parameters on the formation of magnetite nanoparticles prepared by polyol method

Abstract

In this paper we present a modified polyol method for synthesizing magnetite nanoparticles using iron (III) nitrate, a low toxic and cheap precursor salt. The influence of the precursor salt nature and initial ferric concentration in the average particle size and magnetic properties of the obtained nanoparticles were investigated. Magnetite nanoparticles have received much attention due to the multiple uses in the biomedical field; for these purposes nanoparticles with monodisperse size distribution, superparamagnetic behavior and a combination between small average size and high saturation magnetization are required. The polyol conventional method allows synthesizing water-dispersible magnetite nanoparticles with these features employing iron (III) acetylacetonate as precursor salt. Although the particle sizes of samples synthesized from the conventional polyol method (denoted CM) are larger than those of samples synthesized from the modified method (denoted MM), they display similar saturation magnetization. The differences in the nanoparticles average sizes of samples CM and samples MM were explained though the known nanoparticle formation mechanism.

APTES monolayer coverage on self-assembled magnetic nanospheres for controlled release of anticancer drug Nintedanib

“…The saturation magnetization values (M S ) of MNS and MNS-APTES are about 77 emu/g and 74 emu/g. The observed M S values are smaller than the corresponding bulk value (92 emu/g), which is attributed to surface effects in MNS 75 . A relatively small or negligible reduction in the saturation magnetization M S value of MNS was observed after APTES functionalization.…”

Magnetite (Fe3O4) Nanoparticles Synthesis and Anti Green Peach Aphid Activity (Myzuspersicae Sulzer)

“…The particle size and shape of magnetite nanoparticles allows tuning their properties to different applications such as targeted drug delivery, cancer diagnostic, magnetic resonance imaging, catalysts, pharmaceuticals, biomedicine, and agriculture. Various routes and methods have been developed for synthesis magnetite nanoparticles (Fe3O4NPs) such as co-precipitation method (Petcharoen and Sirivat, 2012), solvothermal reduction method (Hou et al, 2003, Ou et al, 2010, thermal decomposition method (Chin et al, 2011, Angermann andTöpfer, 2008 ), electrochemical synthesis (Cabrera and Gutierrez, 2008), sol-gel method (Xu et al, 2007), W/O micro-emulsion (Lu et al, 2004), via a solventfree thermal decomposition route (Maity et al, 2009), hydrothermal synthesis (Ge et al, 2009, Iwasaki et al, 2012, polyol method (Vega-Chacón et al, 2016), high temperature phase reaction of iron acetate in phenyl ether with alcohol (Sun and Zeng, 2002) and by high energy ball milling (de Carvalho et al, 2013). All these methods and routes of synthesis require extra purification steps, reaction times, hazardous by-products, high temperature and difficulty of scale-up, therefore researchers concentrated on the green routes for synthesis magnetite nanoparticles (Fe3O4NPs) due to an eco-friendly, cost-effective and non-toxic routes by using plant extracts such as carob leaf extract (Awwad and Salem, 2012), Pistachio leaf extract (Salem et al, 2013), Kappaphycus alvarezii extract (Yew et al, 2016), Sargassum muticum aqueous extract (Mahdavi et al, 2013), Dhatura innoxia plant extract (Das et al, 2014), Caricaya Papaya Leaves (Latha1 and Gowri, 2014), Azadirachta indica leaf extract (Maheswari and Reddy, 2016), Tridax procumbens leaf extract (Senthil and Ramesh, 2012), Averrhoa carambola (Ahmed et al, 2015), Jatropha gosspifolia leaves (Karkuzhali and Yogamoorthi, 2015), and hordeum vulgare and Rumexacetosa plants (Valentin et al, 2014).…”

Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice

“…34,35 The polydispersity of G 4 @IONPs as measured Table 2 The effect of most crucial parameters in IONPs synthesis. The effect of an increase of these parameters (in an optimum range) was shown on bare IONPs characteristics Increase 40 -- Abbreviation: IONPs, iron oxide nanoparticles. by TEM and DLS was approximately 32%.…”

“…38,39 These parameters and their effects on synthesized IONPs are listed in Table 2. [40][41][42][43][44] In this study, we synthesized IONPs through a fast method, which took approximately 5 min to complete and did not require heating, which simplified the synthesis process.…”