Preparation of the Potential Ocular Inserts by Electrospinning Method to Achieve the Prolong Release Profile of Triamcinolone Acetonide

Mirzaeei, Shahla; berenjian, kaveh; Khazaei, Rasol

doi:10.15171/apb.2018.003

Cited by 51 publications

(29 citation statements)

References 23 publications

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“…The determined average of zeta potential of the nanofibers was -13.5 ± 0.17 mV (Figure 3), indicating fiber stability being the repulsive charge between the fibers enough to avoid agglomeration [24][25]. It has also been reported that the negative zeta potential shows a significant promising impact on the attachment and proliferation of the bone cells.…”

Section: Resultsmentioning

confidence: 99%

Preparation and study of starch/ collagen/ polycaprolactone nanofiber scaffolds for bone tissue engineering using electrospinning technique

Ghavimi

Negahdari

Shahabadi

et al. 2020

Eurasian Chem. Commun.

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Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented method for bone regeneration. The aim of the current work is to produce nanofiber scaffolds based on starch/ collagen/ polycaprolactone (PCL) biomaterials by means of an electrospinning methodology for bone tissue engineering purposes. The results showed that the developed structures have good physicochemical and interconnected properties that could be considered for bone tissues engineering. The results from the characterization specified that the nanofibers were successfully prepared with monodispersed nanosized diameter (60 nm), uniform network shaped morphology and negative surface charge (-13.5 mV). Besides, the applied method can be set up to prepare fiber-based structures using other polymeric materials. We believe that by incorporating different materials to reduce the degradation rate of the fibers, it can be matched with the speed of tissue regeneration. In this case, the prepared nanofibers can be used as the membrane biomaterials, for example, guided bone regeneration (GBR) membrane.

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Section: Resultsmentioning

confidence: 99%

Preparation and study of starch/ collagen/ polycaprolactone nanofiber scaffolds for bone tissue engineering using electrospinning technique

Ghavimi

Negahdari

Shahabadi

et al. 2020

Eurasian Chem. Commun.

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“…This formulation increased the contact time between the drug and the conjunctival tissue, and thus decreased the number of administrations needed. This work showed that the concept of nanofibers in ophthalmic drug delivery is feasible [53].…”

Section: Nanofibers In Ocular Drug Deliverymentioning

confidence: 91%

Nanofibers in Mucosal Drug and Vaccine Delivery

Mašek¹,

Mašková²,

Lubasová³

et al. 2020

Nanomaterials - Toxicity, Human Health and Environment

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Successful mucosal administration and delivery of drugs still pose a great challenge. However, the possibility to deliver not only small drug molecules but also macromolecular drugs and nanoparticles via mucosal surfaces represents a great opportunity. Rapid onset of drug action, avoidance of first-pass metabolism, and high immunocompetence of mucosa are some of the important features for mucosal drug and vaccine delivery. The use of mucoadhesive drug delivery systems, systems with fast dissolving properties, and nanomaterials with mucus penetration properties are examples of successful strategies to achieve effective mucosal drug and vaccine delivery. Non-keratinized mucosa of the oral cavity, the nasal and vaginal mucosa represent favorable sites of drug administration. Polymer nanofibers have attracted much attention because of remarkable characteristics such as a large surface area to volume ratio and high porosity. Nanofibers have been extensively used for different biomedical applications including wound dressing, tissue engineering, and drug delivery. Among their fabrication methods, the introduction of electrospinning technique was an important step toward achieving the goal of large scale industrial production of nanofiber-based drug delivery systems used in mucosal applications. This chapter provides an overview on all aspects of mucosal drug and vaccine delivery using nanofibers.

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“…Mirzaeei et al examined CS-based electrospun nanofibers as ocular inserts for the delivery of triamcinolone acetonide [293]. Hydrophilic fibers were prepared using CS and PVA and/or poly(vinyl pyrrolidine) and compared to hydrophobic fibers constituted of Eudragit S100 and Zein.…”

Section: Ocular Lenses and Insertsmentioning

confidence: 99%

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.

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Preparation of the Potential Ocular Inserts by Electrospinning Method to Achieve the Prolong Release Profile of Triamcinolone Acetonide

Cited by 51 publications

References 23 publications

Preparation and study of starch/ collagen/ polycaprolactone nanofiber scaffolds for bone tissue engineering using electrospinning technique

Preparation and study of starch/ collagen/ polycaprolactone nanofiber scaffolds for bone tissue engineering using electrospinning technique

Nanofibers in Mucosal Drug and Vaccine Delivery

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

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