Preparation of the amphiphilic copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate nanoparticles and the study of their properties in vitro

Structure and State of Water in Branched N-Vinylpyrrolidone Copolymers as Carriers of a Hydrophilic Biologically Active Compound

“…Insufficient differences in −∆ H values did not allow unambiguous conclusions on the water molecule coordination. However, it was stated experimentally that these copolymers were monomolecular micelles, or their aggregates in aqueous solutions with hydrophilic shells consisted of VP unites [ 45 , 46 , 47 , 48 ]. Taking this data into consideration, the quantum chemical modeling of VP-VP-VP moieties with water molecules seems to be the most relevant.…”

“…The molecular weight of the copolymers and linear PVP was determined by SEC on a Waters GPCV 2000 chromatograph (2 PS gel columns, 5 μm, MIXED-C, 300 × 7.5 mm Waters, Milford, MA, USA), as described in [ 46 ] using two detectors (RI + MALLS)—refractometric and WYATT DAWN HELEOS II light scattering (λ = 658 nm), software Empower Pro and Astra (5.3.2.20 version). The molecular weights were measured at a temperature of 70 °C; LiCl (1% wt.)…”

“…We synthesized amphiphilic copolymers of VP with dimethacrylates [ 44 ] that were excellent precursors to form biologically active compound (BAC) nanostructures [ 45 , 46 , 47 , 48 ]. They have low cytotoxicity and are able to penetrate into cells [ 46 ].…”

“…We synthesized amphiphilic copolymers of VP with dimethacrylates [ 44 ] that were excellent precursors to form biologically active compound (BAC) nanostructures [ 45 , 46 , 47 , 48 ]. They have low cytotoxicity and are able to penetrate into cells [ 46 ]. For instance, they proved to be useful as potential carriers of hydrophobic compounds such as fullerene С 60 [ 45 ] and zinc(II) tetraphenylporphyrin [ 46 , 47 ], and they were also approved as NO-carried systems of binuclear tetranitrosyl iron complexes [ 48 ] or Pt IV complexes [ 49 , 50 ] with antitumor activity.…”

“…They have low cytotoxicity and are able to penetrate into cells [ 46 ]. For instance, they proved to be useful as potential carriers of hydrophobic compounds such as fullerene С 60 [ 45 ] and zinc(II) tetraphenylporphyrin [ 46 , 47 ], and they were also approved as NO-carried systems of binuclear tetranitrosyl iron complexes [ 48 ] or Pt IV complexes [ 49 , 50 ] with antitumor activity. Apparently, these copolymers could be also used as platform for hydrophilic BAC-forming complexes via associated water.…”