New complexes of metformin based on the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate and their activity in experimental type 2 diabetes mellitus

Kurmaz, S. V.; Фадеева, Н. В.; Soldatova, Yuliya V.; Faingold, I. I.; Poletaeva, D. A.; Ignat'ev, V. M.; Emel’yanova, N. S.; Шилов, Г. В.; Kotelnikova, R. A.

doi:10.1007/s10965-021-02684-x

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…The high biocompatibility of polymer carriers and their ability to penetrate into HeLa cells have been demonstrated in vitro, which indicates that the developed delivery materials are promising for the intracellular delivery of BAC. During in vivo experiments, the VP-TEGDM copolymer does not exhibit any toxicity, as well as its complex with metformin [46].…”

Section: Introductionmentioning

confidence: 98%

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

et al. 2022

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Nanosized systems of DOX with antitumor activity on the base of micelle-like particles of amphiphilic thermosensitive copolymers of N-vinylpyrrolidone (VP) with triethylene glycol dimethacrylate (TEGDM), and N-vinylpyrrolidone and methacrylic acid (MAA) with TEGDM were explored. They were investigated in aqueous solutions by electron absorption spectroscopy, dynamic light scattering and cyclic voltammetry. Experimental data and quantum-chemical modeling indicated the formation of a hydrogen bond between oxygen-containing groups of monomer units of the copolymers and H-atoms of OH and NH2 groups of DOX; the energies and H-bond lengths in the considered structures were calculated. A simulation of TDDFT spectra of DOX and its complexes with the VP and TEGDM units was carried out. Electrochemical studies in PBS have demonstrated that the oxidation of encapsulated DOX appeared to be easier than that of the free one, and its reduction was somewhat more difficult. The cytotoxicity of VP-TEGDM copolymer compositions containing 1, 5 and 15 wt% DOX was studied in vitro on HeLa cells, and the values of IC50 doses were determined at 24 and 72 h of exposure. The copolymer compositions containing 5 and 15 wt% DOX accumulated actively in cell nuclei and did not cause visual changes in cell morphology.

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Section: Introductionmentioning

confidence: 98%

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

et al. 2022

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“…The high biocompatibility of polymer carriers and their ability to penetrate into Vero and HeLa cells have been demonstrated in vitro, which indicates that the developed copolymers are promising for the intracellular delivery of commercial drugs and original compounds with biological activity. In in vivo experiments, the VP-copolymer exhibits no toxicity [38].…”

Section: Introductionmentioning

confidence: 98%

“…We used the radical polymerization in solution in the presence of 1-decanthiole as traditional CTA [32] or without it [33][34][35][36][37][38][39] to produce amphiphilic VP-dimethacrylate copolymers of various compositions, molecular weights, and architectures at high yields within 2-3 h. Their molecular weight distribution (MWD) and compositional heterogeneity may be improved by fractionation. A controlled radical polymerization technique, such as RAFT, is more effective for the synthesis of a compositionally homogeneous copolymer with a narrow MWD.…”

Section: Introductionmentioning

confidence: 99%

Macromolecular Design and Engineering of New Amphiphilic N-Vinylpyrrolidone Terpolymers for Biomedical Applications

Kurmaz,

Perepelitsina,

Vasiliev

et al. 2023

IJMS

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New amphiphilic VP-(di)methacrylate terpolymers of different monomer compositions and topologies have been synthesized by radical polymerization in toluene without any growth regulator of polymer chains. Their structures and properties in solid state and water solution were studied by double-detector size-exclusion chromatography; IR-, 1H, and 13C NMR-spectroscopy; DLS, TEM, TG, and DSC methods. The composition of the VP-AlkMA-TEGDM monomer mixture has been established to regulate the topology of the resulting macromolecules. The studied terpolymers presented on TEM images as individual low-contrast particles and their conglomerates of various sizes with highly ordered regions; in general, they are amorphous structures. None of the terpolymers demonstrated cytotoxic effects for noncancerous Vero and tumor HeLa cells. Hydrophobic D-α-tocopherol (TP) was encapsulated in terpolymer nanoparticles (NPs), and its antioxidant activity was evaluated by ABTS (radical monocation 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)) or DPPH (2,2′-diphenyl-1-picrylhydrazyl) methods. The reaction efficiency depends on the TP-NP type. The IC50 values for the decolorization reaction of ABTS•+ and DPPH inhibition in the presence of initial and encapsulated TP were obtained.

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Nanoscale systems folic acid—amphiphilic copolymer of N-vinylpyrrolidone with methacrylic acid, branched with triethylene glycol dimethacrylate

et al. 2023

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New complexes of metformin based on the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate and their activity in experimental type 2 diabetes mellitus

Cited by 6 publications

References 47 publications

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

Macromolecular Design and Engineering of New Amphiphilic N-Vinylpyrrolidone Terpolymers for Biomedical Applications

Nanoscale systems folic acid—amphiphilic copolymer of N-vinylpyrrolidone with methacrylic acid, branched with triethylene glycol dimethacrylate

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