Preparation of starch macrocellular foam for increasing the dissolution rate of poorly water-soluble drugs

Zhao, Ying; Wu, Chao; Zhao, Zongzhe; Hao, Yanna; Xu, Jie; Yu, Tong; Qiu, Yang; Jiang, Jie

doi:10.3109/10837450.2015.1055763

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…According to the Noyes–Whitney equation, the dissolution rate was proportional to the specific surface area of the drug particles. 48 Therefore, MSn could significantly increase the dissolution rate of FNB, the major reason for improving the dissolution rate. These results confirmed that MSn was well suited as an oral drug carrier.…”

Section: Resultsmentioning

confidence: 99%

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai

et al. 2018

DDDT

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BackgroundBiopharmaceutics classification system class II drugs have low solubility, which limits their extent and speed of absorption after oral administration. Over the years, mesoporous materials have been widely used to increase the dissolution rate and oral relative bioavailability of poorly water-soluble drugs.ObjectivesIn order to improve the dissolution rate and increase oral relative bioavailability of the poorly water-soluble drugs, a tin oxide carrier (MSn) with a mesoporous structure was successfully synthesized.MethodsIn this study, MSn was synthesized using mesoporous silica material (SBA-15) as the template. Fenofibrate (FNB) was adsorbed into the channels of MSn by an adsorption method. Characterizations of the pure FNB, MSn, physical mixture of the drug and MSn (PM; 1:1) and FNB-loaded MSn (FNB-MSn) samples were carried out by the scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption/desorption, powder X-ray diffractometer (PXRD), differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectroscopy. Cytotoxicity assay (MTT) was used to evaluate the cytotoxicity of MSn. In vitro dissolution studies were performed to investigate the dissolution rate of FNB-MSn. In vivo pharmacokinetic studies were used to investigate the changes of plasma drug concentrations of FNB-MSn tablets and commercial FNB tablets in rabbits.ResultsDetailed characterization showed that FNB in the channels of MSn was present in an amorphous state. The in vitro release tests demonstrated that MSn with a good biocompatibility could effectively enhance the dissolution rate of FNB. Pharmacokinetic results indicated that MSn significantly increased the oral relative bioavailability of FNB.ConclusionMSn can be regarded as a promising carrier for an oral drug delivery system.

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Section: Resultsmentioning

confidence: 99%

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai

et al. 2018

DDDT

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“…30 Starch macrocellular foam (SMF) has been used to improve the dissolution rate and oral bioavailability of nitrendipine (NDP); the results demonstrated that SMF can be a promising carrier for the oral delivery of poorly water-soluble drugs. 35 The use of porous starch as a carrier for carbamazepine also enhanced its solubility. 13 García-González et al reported that starch aerogel microspheres can be used as carriers for ketoprofen, as they showed high loading capacities.…”

Section: Porous Starch In Drug Delivery Systemsmentioning

confidence: 99%

Porous starch and its application in drug delivery systems

Sujka¹,

Pankiewicz²,

Kowalski³

et al. 2018

Polim. Med.

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In recent years, starch has become a new potential biomaterial for pharmaceutical applications. This biopolymer has unique physicochemical and functional characteristics, as well as various advantages such as low price, relative ease of isolation in pure form from the plant source, non-toxicity, biodegradability, good biocompatibility, and interaction with living cells. Starch is currently used in pharmacy as a binder, disintegrating agent, film-forming material, raw material for production of microspheres and nanoparticles, and a component of drug delivery systems. Porous starch, which can be obtained with physical, chemical and enzymatic methods of modification, has a large specific surface area thanks to the presence of pores and channels. It has excellent adsorption capacity and can be used to enhance the dissolution rate of poorly soluble drugs or as shell material to improve the stability and water-solubility of compounds. As a component of drug delivery systems, porous starch has another advantage: it is biodegradable, so there is no need to remove it from the body after the release of the active agent.

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“…In addition, the PS is also an ideal drug delivery system because of its advantages of biocompatibility, bioadhesive, and capable of high drug loading, and the PS is officially accepted by all major regulatory agencies for use in various oral drug delivery systems (Wu et al., 2011 ). So far, the PS has been applied to many lipophilic drugs, such as lovastatin (Wu et al., 2011 ), nitrendipine (Zhao et al., 2016 ), carbamazepine (Ali et al., 2013 ), and ketoprofen (García-González et al., 2012 ), etc., so as to improve its solubility and absorption in vivo .…”

Section: Introductionmentioning

confidence: 99%

Construction, characterization, and bioavailability evaluation of honokiol-loaded porous starch by melting method without any solvent

Wei

2021

Drug Delivery

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In the present study, the porous starch (PS) was used as an efficient carrier of honokiol (HK), and the HK-loaded PS (HPS) delivery system was prepared by melting method without using organic solvents. Its physical-chemical properties, solubility and oral bioavailability were also investigated. The obtained results proved that the HK in the HPS was mostly amorphous when it was loaded into the PSs with 87.54 ± 1.52% of encapsulation efficiency (EE) and 12.51 ± 0.22% of drug loading (DL) capacity. The water-solubility of the HPS was increased to 115.27 ± 2.92 μg/mL (pH = 1.2, artificial gastric juice (AGJ)), 161.58 ± 3.42 (pH = 6.8, artificial intestinal juice (AIJ)) and 148.5 ± 1.89 μg/mL (pH = 5.5, simulated tumor microenvironment), being 6.07, 4.38 and 4.87-folds higher than free HK. In vitro dissolution tests showed the HK was significantly higher from HPS than from free HK. Furthermore, compared with free HK, the release rate and the bioavailability was also substantially improved for HK from the HPS. Meanwhile, the HPS generated a higher inhibition to HepG2 cells than free HK.

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Preparation of starch macrocellular foam for increasing the dissolution rate of poorly water-soluble drugs

Cited by 4 publications

References 32 publications

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Porous starch and its application in drug delivery systems

Construction, characterization, and bioavailability evaluation of honokiol-loaded porous starch by melting method without any solvent

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