Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Abstract

BackgroundBiopharmaceutics classification system class II drugs have low solubility, which limits their extent and speed of absorption after oral administration. Over the years, mesoporous materials have been widely used to increase the dissolution rate and oral relative bioavailability of poorly water-soluble drugs.ObjectivesIn order to improve the dissolution rate and increase oral relative bioavailability of the poorly water-soluble drugs, a tin oxide carrier (MSn) with a mesoporous structure was successfully synthesized.MethodsIn this study, MSn was synthesized using mesoporous silica material (SBA-15) as the template. Fenofibrate (FNB) was adsorbed into the channels of MSn by an adsorption method. Characterizations of the pure FNB, MSn, physical mixture of the drug and MSn (PM; 1:1) and FNB-loaded MSn (FNB-MSn) samples were carried out by the scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption/desorption, powder X-ray diffractometer (PXRD), differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectroscopy. Cytotoxicity assay (MTT) was used to evaluate the cytotoxicity of MSn. In vitro dissolution studies were performed to investigate the dissolution rate of FNB-MSn. In vivo pharmacokinetic studies were used to investigate the changes of plasma drug concentrations of FNB-MSn tablets and commercial FNB tablets in rabbits.ResultsDetailed characterization showed that FNB in the channels of MSn was present in an amorphous state. The in vitro release tests demonstrated that MSn with a good biocompatibility could effectively enhance the dissolution rate of FNB. Pharmacokinetic results indicated that MSn significantly increased the oral relative bioavailability of FNB.ConclusionMSn can be regarded as a promising carrier for an oral drug delivery system.

Heterogeneous Catalysts Containing an Anderson-Type Polyoxometalate for the Aerobic Oxidation of Sulfur-Containing Compounds

“…SEM images of the catalyst samples in Figure show a long-rod morphology in a bundle arrangement with a particle size of less than 1 μm. The same morphology is observed for typical SBA-15. , The synthesized materials display typical fibrous type morphologies, indicating that the morphology did not change during the surface modification.…”

“…The same morphology is observed for typical SBA-15. 53,54 The synthesized materials display typical fibrous type morphologies, indicating that the morphology did not change during the surface modification.…”

Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat

“…Compared with other materials, mesoporous tin dioxide, as a metal oxide nanocarrier, has promising applications as a potential pharmaceutical excipient. Andi Bai et al ( Bai et al, 2018 ) used tin dioxide with a mesoporous structure to improve the oral relative bioavailability of fenofibrate, and the results showed that tin dioxide has great potential in improving the aqueous solubility and enhancing the bioavailability of insoluble drugs. In this study, we prepared hollow tin dioxide (HSn) nanocarriers by a hydrothermal synthesis method.…”

In-Vitro and In-Vivo Evaluation of Velpatasvir- Loaded Mesoporous Silica Scaffolds. A Prospective Carrier for Drug Bioavailability Enhancement

“…Poorly soluble drugs cause many issues which include dose escalation, low bioavailability, and poor in-vitro and in-vivo drug performance [2]. To curtail this issue, scientists have adopted various approaches, for example micronization, complexation, lipid-based formulations, co-solvents, salt formation, solid dispersions, nano-formulations and many more [3,4]. Among the above-mentioned techniques, nanocarriers, which include drug nanocrystals [5][6][7], nanoemulsions [8][9][10], polymeric micelles [11,12], nanoparticles [13,14], nanotubes [13], and silica-based nanocarriers [15] are widely investigated by scientists.…”