Preparation of Single Chain Nanoparticles via Photoinduced Double Collapse Process

Abstract

Front Cover: In article number 1900116, Gokhan Temel and co‐workers discuss a straightforward method to achieve polymeric nanoparticles by double folding of single linear chains via photoinduced radical coupling and azide crosslinking using simultaneous and subsequent pathways. Particle size and glass transition temperature of resulting nanoparticles can be altered by the second folding/collapse process.

Synthesis and Controlled Cargo Release of Novel Photoresponsive Polysiloxane‐Based Single‐Chain Nanoparticles

“…UV light is particularly useful since release kinetics of encapsulated molecules can be precisely controlled by tuning irradiation parameters (wavelength and irradiation power); something which is difficult to achieve through various other stimuli such as pH, temperature, and enzymatic activity [ 19 ] due to the complex human physiology. In addition, UV‐triggered reactions have been successfully utilized in the formation of SCNPs using various techniques such as azide crosslinking, [ 20 ] Diels–Alder, [ 21 ] ketyl combination, [ 22 ] and [2+2] crosslinking of coumarin [ 23,24 ] and anthracene. [ 25 ] With a wide variety of UV‐triggered reaction choices, the photoreversible [2+2] reaction is favorable since minimal to no by‐products are formed; it is photoreversible; reaction efficiencies are high; and it can be carried out in the solution or solid state.…”

Single‐chain polymer nanoparticles via click crosslinking and effect of photoinduced radical combination on crosslink points

“…In our previous work, we introduced single‐chain nanoparticles via photoinduced radical coupling (PRC) strategies 22,23 . Pendent benzophenone containing copolymers were transformed into polymeric nanoparticles by single or double folding processes under UV light illumination at high dilution conditions.…”