Preparation of quadruple responsive polymeric micelles combining temperature‐, pH‐, redox‐, and UV‐responsive behaviors and its application in controlled release system

Abstract

A novel series of quadruple responsive copolymers, poly(ethylene glycol)‐ss‐[poly(dimethylaminoethyl methacrylate)‐co‐poly(2‐nitrobenzyl methacrylate)] [PEG‐ss‐(PDMAEMA‐co‐PNBM)], were synthesized via atom transfer radical polymerization mediated by home‐made PEG‐based macro‐initiator labeled with disulfides. The obtained copolymers could self‐assemble in aqueous solution forming micelles with the disulfide bridge linking the hydrophilic coronas (PEG) and the hydrophobic cores (PDMAEMA‐co‐PNBM). Investigation on the resulted micelles indicated that the micelles could respond to various stimuli, that is, temperature, pH, the presence of dithiothreitol (DTT), and UV irradiation. Moreover, the responsive behavior of the micelles depends on the type of stimuli, that is, temperature change causes size change of the micelles, while UV irradiation leads to dissolution of the self‐assembled structures. Such stimulus‐dependent responsive behavior could be applied in smart materials that deal with multi‐tasks or in the construction of complex logic gate. The potential application of the multi‐responsive micelles in cargo release system was also evaluated using Nile Red (NR) as model molecule. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46675.

DePEGylation strategies to increase cancer nanomedicine efficacy

“…* this route does not overcome the "PEG dilemma" and the very limited uptake of PEGylated nanoparticles is a major drawback of these systems. [46][47][48][49] Micelles [50] Hydrazone Liposomes [52][53][54] Micelles [55][56][57][58][59][60][61] Acetal Liposomes [62] Micelles [63][64][65][66][67][68][69] β-thiopropionate Micelles [70] Ortho ester Liposomes [71][72][73] Benzoic-imine Micelles [74][75][76] Reduction Glutathione (GSH) (2-10 mM) Liposomes [93] Polymersomes [94,95] Micelles 133] Graphene Oxide [122][123][124] Mesoporous silica nanoparticles (MSN) [125][126][127][128][129][130][131][132] Magnetic nanoparticles [134] Enzymatic Cathepsin B (peptide consensus sequence)…”

Physically stimulus-responsive nanoparticles for therapy and diagnosis

“…Triple-triggered PMs are thermal/reduction/pH-responsive ( Sun et al, 2018b ; Qu et al, 2018 ), thermal/ultrasound/reduction-responsive ( Lin et al, 2018 ), and light/temperature/pH- responsive ( Falireas and Vamvakaki, 2018 ). Even quadruple temperature, pH, redox, and UV light ( Dong et al, 2018 ), quintuple light, temperature, pH, and dual redox stimuli-responsive PMs ( Zhang K. et al, 2018 ) are synthesized and applied in the controlled delivery of therapeutic cargos.…”

“…The in vitro release profile was investigated by the use of hydrophobic NR drug. Each stimulus has a specific effect on these multi-responsive PMs; as the temperature changed the size of the micelle, the micelle swelled in low pH, a few amounts of DTT disarranged the micelle configuration, and irradiation of UV light caused the dissolution of the micelle construction ( Dong et al, 2018 ).…”

Light- and Redox-Responsive Block Copolymers of mPEG-SS-ONBMA as a Smart Drug Delivery Carrier for Cancer Therapy

“…Responsiveness to ultraviolet (UV) light can be easily tuned by controlling the numbers of ONBMA in the block copolymers. Dong et al have synthesized poly(ethylene glycol)-SS-[poly(dimethylaminoethyl methacrylate)-co-poly(2-nitrobenzyl methacrylate)] [PEG-SS-(PDMAEMA-co-PNBM)] and demonstrated a quadruple responsive property of the copolymer; nevertheless, the authors did not study any potentials of using this copolymer for DDS [11].…”