Preparation of pyridyltriazole ruthenium complexes as effective catalysts for the selective alkylation and one-pot C–H hydroxylation of 2-oxindole with alcohols and mechanism exploration

Abstract

Pyridyltriazole-ligated ruthenium(ii) complexes have been designed and synthesized, which were characterized by X-ray crystallography.

Et3N‐ Promoted Cascade Sp3 C‐H Bond Functionalization of Methyl Arene with Active Methylene CompoundsUnder Solvent‐Free Condition

“…Recently the selective and controlled oxidation of benzylic carbon-hydrogen (C-H) bond of methylarene (2)(3)(4)(5) has emerged as an inspiring and challenging topic for the chemist. The conventional method for getting benzaldehyde are non-selective, tiresome, poisonous and operationally tricky (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). In this perspective, the direct selective oxidation of methyl arenes to benzaldehydes (18)(19)(20)(21)(22)(23) is of vital importance.…”

Iridium Supported on Phosphorus‐Doped Porous Organic Polymers: Active and Recyclable Catalyst for Acceptorless Dehydrogenation and Borrowing Hydrogen Reaction

“…[11] Hydrogen auto-transfer methodology, also named borrowing hydrogen reaction, has attracted increasing attention during the past decade, as this method provides a mild, green and economical pathway to achieve alkylation of ketones and amines. [17] As a part of our continuing work on borrowing hydrogen reactions, [18] herein, we reported an innovative heterogeneous iridium catalyst (POPÀ Ir) which was supported on phosphorusdoped porous organic polymers ( Figure 1). [14] This method provides an environmentally friendly strategy to achieve the goal of sustainable and green chemistry.…”

“…[16] However, these metal complexes are costly and exhibited low reusability, thereby, creating massive waste during organic synthesis process. [17] As a part of our continuing work on borrowing hydrogen reactions, [18] herein, we reported an innovative heterogeneous iridium catalyst (POPÀ Ir) which was supported on phosphorusdoped porous organic polymers ( Figure 1). The POPÀ Ir catalyst has revealed excellent catalytic activity in the reaction of diphenyl phosphinamide with benzyl alcohol through borrowing hydrogen strategy and acceptorless dehydrogenation with wide tolerance of functional group.…”

Cobalt Used as a Novel and Reusable Catalyst: A New and One-Pot Synthesis of Isatin-Derived N,S-Acetals Using Substituted Isatins and Thiols

“…3 In this context, we were interested in synthesizing a series of 3-functionalized 2-oxindoles, once such scaffolds are an attractive class of heterocycles present in many natural compounds and for example, can be biologically applied on human tumor cells. [4][5][6][7][8] Moreover, the functionalization at C3-position of the oxindole core was reported by various researchers to access 3,3-disubstituted 2oxindoles. 5 Yang and co-workers developed the direct aminoalkylation of isatins to access to 3-hydroxy-3-aminoal-kylindolin-2-ones by visible light.…”

“…6 Wang and co-workers reported a ruthenium-catalyzed alkylation via one-pot C-H hydroxylation of 2-oxindoles with alcohols. 7 Novellino et al synthesized isatin derivative N,S-acetals from isatin and Lcysteine. 9 Gomez-Monterrey's group synthesized a series of spiro(oxindole-3,3-thiazolidine) as p53 modulator using both isatin and L-cysteine derivatives.…”