Preparation of polyvinyl alcohol, chitosan and polyurethane-based pH-sensitive and biodegradable hydrogels for controlled drug release applications

Kamacı, Umran Duru; Kamacı, Musa

doi:10.1080/00914037.2019.1670180

Cited by 26 publications

(9 citation statements)

References 39 publications

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“…At certain time intervals, the hybrid hydrogel samples were removed from this medium and weighed with a mass of m final . % Biodegradation of the hydrogel sample was calculated as the following equation 2 23 :

% Biodegradation = \frac{W_{italicinitial} - W_{italicfinal}}{W_{initial}} \times 100 .

…”

Section: Methodsmentioning

confidence: 99%

Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties

Kamacı

Kaya

2022

Polymers for Advanced Techs

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In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5‐fluorouracil. The fabricated hydrogels were characterized via FT‐IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5‐FU due to these properties.

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% Biodegradation = \frac{W_{italicinitial} - W_{italicfinal}}{W_{initial}} \times 100 .

…”

Section: Methodsmentioning

confidence: 99%

Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties

Kamacı

Kaya

2022

Polymers for Advanced Techs

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“…These experiments were carried out as follows: the PU and CS‐based hydrogel samples were placed in 8 ml PBS, and they were removed from the solution at certain time intervals and weighed. % Biodegradation rate of the prepared was calculated as the following Equation (2) 10 :

% Biodegradation rate ((), BR) goodbreak= \frac{W_{before} - W_{after}}{W_{before}} normalx 100

where w after and w before are the weights of after and before biodegradation experiment.…”

Section: Methodsmentioning

confidence: 99%

“…In recent years, polyurethane‐based hydrogels have attracted much attention due to their biological versatility, good biocompatibility, and easy processability 7,8 . They have been used in biomedical applications such as controlled drug delivery, tissue engineering, wound dressing, scaffolds, and tissue adhesives 9–11 . Despite these superior properties, polyurethane hydrogels are susceptible to degradation depending on their chemical structure and topology 12 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of biodegradable hydrogels based on chitosan and poly(azomethine‐urethane) containing phenyl triazine for drug delivery

Kamacı

Kaya

2022

Polymers for Advanced Techs

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A series of biodegradable hydrogels based on chitosan and polyurethanes was fabricated to be applied to the drug delivery application, and the fabricated hydrogels were characterized by using SEM, and FT‐IR techniques. Polyurethanes were also synthesized by using the different diisocyanates, and the diisocyanate's effect on the properties of the hydrogels was clarified. The mechanical and thermal properties, % swelling capacity, biodegradation, and hydrophilic or hydrophobic behaviors of the chitosan and polyurethane hydrogels were also clarified. The fabricated hydrogels were demonstrated good biodegradable and antibacterial behaviors. The cumulative drug release of the hydrogels was revealed that they have around 50% drug release capacity, and according to the obtained results, the chitosan and polyurethane‐based hydrogels have a potential drug delivery application of 5‐fluorouracil.

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“…Due to tissue-like softness and compatibility, [1][2][3] hydrogels are fascinating materials for bioelectronics, such as wearable and implantable devices, 4,5 sensors, [6][7][8][9] touch panels, 9,10 and energy storage configurations. [11][12][13] The primary challenge of the hydrogels for flexible electronics, however, is to integrate excellent mechanical strength and conductivity.…”

Section: Introductionmentioning

confidence: 99%

Long‐lasting moisture and anti‐freezing tough organohydrogels based on multi‐functional nano‐micelles for flexible dual‐response sensors

Yu-rong

et al. 2022

J of Applied Polymer Sci

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Conductive hydrogels have attracted widespread attention in diverse applications. However, the fragile nature of conducting polymers hinders the long‐time stability of the hydrogels. What's more, hydrogels will lose elasticity and conductivity at room temperature or sub‐zero temperature because of the high water content. Herein, we proposed a long‐term stable and anti‐freezing organohydrogel with high stretchability (up to 1140%), which consist of multi‐functional nano‐micelles (Pluronic F127 diacrylate [F127DA]), Polyacrylamide, and Poly(3,4‐ethylenedioxythiophene): polystryrene sulfonate (PEDOT:PSS) in a water/glycerin binary solvent system. The gel is thermal tolerant to maintain all the properties under extreme wide temperature spectrum (−40°C or 60°C). More importantly, the organohydrogel possesses excellent recognition capability to multiple stimuli. It is anticipated that this organohydrogel will have great potential in sensing applications.

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Preparation of polyvinyl alcohol, chitosan and polyurethane-based pH-sensitive and biodegradable hydrogels for controlled drug release applications

Cited by 26 publications

References 39 publications

Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties

Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties

Fabrication of biodegradable hydrogels based on chitosan and poly(azomethine‐urethane) containing phenyl triazine for drug delivery

Long‐lasting moisture and anti‐freezing tough organohydrogels based on multi‐functional nano‐micelles for flexible dual‐response sensors

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