Preparation of polymeric porous materials by interparticle crosslinking

Dauben, Michael; Reichert, Karl‐Heinz; Huang, Pengcheng; Fock, J.

doi:10.1016/0032-3861(96)87647-6

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…Collagen‐like materials exhibit high biocompatibility, pore density, and biodegradation 2. Appropriate pore density allows for seeding and propagation of cells whereas biodegradation rate is controlled by crosslinking and hydrophilicity 3. Other natural materials such as chitosan, derived from chitin, have also been studied 4.…”

Section: Introductionmentioning

confidence: 99%

Thermally reversible polymer gel for chondrocyte culture

Polotsky

et al. 2003

J Biomedical Materials Res

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We have evaluated a biomaterial to serve as a scaffold for the propagation and amplification of chondrocytes that promotes the original cellular phenotype of these cells. The goal of the present study was to investigate the use of thermally reversible polymer gels poly(NiPAAm-co-AAc), as a biocompatible supporting scaffold for the propagation of chondrocytic cells. The polymer gels at temperatures above its lower critical solution temperature whereas liquefying at temperatures below its lower critical solution temperature of 34.5 degrees C. Hence, the polymer, in its gelled form, has the ability to hold cells in situ, forming a matrix similar to the natural cellular environment or the extracellular matrix that comprises cartilage. We tested the hypothesis that the polymer gel promotes cell viability and function. Human osteoblast-like cells, nasal chondrocytes, and articular chondrocytes (1 x 10(5)/150 microL) were resuspended in enriched Dulbecco's minimal essential media and were plated onto control (without gel) and gel containing 24-well plates. The plates were reincubated at 37 degrees C, 5% CO(2) for the time point of interest. Additional media was added to the plates and exchanged as needed. After cell culture, cells were retrieved, enumerated, and cell viability was determined. Other aliquots of the cells were stained for morphological analysis whereas expression of chondrocyte markers including collagen type II and aggrecan were determined using reverse transcriptase-polymerase chain reaction. The polymer gel was not cytotoxic because the cell number retrieved from three-dimensional culture gel was found to be one to two times higher than that retrieved from monolayer culture. Chondrocytes propagated in the thermo-reversible polymers expressed enhanced or maintained expression of collagen type II and aggrecan. Collagen type I expression was decreased or unaltered. The N-isopropylacrylamide and acrylic acid copolymer gel has potential use as a cell culture substrate and as a cell delivery vehicle.

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Section: Introductionmentioning

confidence: 99%

Thermally reversible polymer gel for chondrocyte culture

Polotsky

et al. 2003

J Biomedical Materials Res

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“…The following procedures 8 were used to support the prepared polymer with metal and metal oxide catalysts. One g of the porous poly(HYOX) is immersed in different salt solutions (5000 ppm) of (Cr, Fe, Co, Ni, Pd, Cd, and Cu) and stirred at room temperature for 1 h. After the polymer turned to the characteristic color of the salt solution, it was filtered and dried at 60°C.…”

Section: Poly(hyox) As a Catalyst-supporting Materialsmentioning

confidence: 99%

Synthesis and characterization of highly porous poly(methacrylic-co-triethylene glycol dimethacrylate) by suspension polymerization

Moustafa

Faizalla

1999

J. Appl. Polym. Sci.

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Porous poly(methacrylic-co-triethyleneglycol dimethacrylate) (MAA-3G) was prepared by suspension polymerization using benzoyl peroxide as an initiator, poly(vinyl alcohol) as a protective colloid, and n-hexane as a porogenic agent. The prepared polymer was base hydrolysed using hydroxyl amine and sodium methoxide into the corresponding polyhydroxamic acid (HYOX). The metal binding behavior of polyhydroxamic acid with various metal ions, the effect of pH on the metal ion capturing, and the selectivity of the resin towards the different metal ions were also examined by means of atomic absorption spectrophotometer. The thermal stability of the prepared base-hydrolysed polymer and the metal polymer complex was examined by thermal gravimetric analysis (TGA) and differential scanning calorimeter (DSC). The prepared porous polymer methacrylic-co-triethyleneglycol dimethacrylate and its different modulated forms were characterized by means of FTIR specroscopy and scanning electron microscope. The hydroxamic acid content was also examined by elemental analysis.

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“…The design of functional porous polymeric materials has been the subject of widespread interest and intense research, as they are involved in a wide array of applications, e.g. monoliths for chromatographic techniques, separation membranes, interlayer dielectrics, high surface area catalytic supports, as well as size/shape-selective nanoreactors [1][2][3][4][5][6][7][8][9]. Besides the classical synthetic strategies that rely on the use of solvents or gases as porogens, original approaches with porogen templates, capable of inducing specific structural pores within the residual structures, have been developed [10,11].…”

Section: Introductionmentioning

confidence: 99%

Oligoester-Derivatized (Semi-)Interpenetrating Polymer Networks as Nanostructured Precursors to Porous Materials with Tunable Porosity

Grande

Rohman

2019

Chemistry Africa

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Porous polymeric materials with tunable porosity can be engineered from oligoester-derivatized semi-interpenetrating polymer networks (semi-IPNs) or IPNs, respectively composed of either uncrosslinked or crosslinked aliphatic oligoesters entangled in a stiff subnetwork. In this paper, miscellaneous polyester/poly(methyl methacrylate)-based semi-IPN and IPN systems are first prepared as precursors with varying structural parameters, especially the nature [i.e., poly(d,l-lactide), poly(ε-caprolactone)] and the molar mass (i.e., from 560 to 3700 g mol −1) of the oligoester precursor. (Nano)porous networks with defined porosity are then generated through two complementary routes. This original paper discusses the scope and limitations of both approaches and investigates the correlation between the structure and morphology of the generated networks and the porosity of the resulting porous materials. We demonstrate that the choice of the precursors with defined compatibility is of paramount significance in the length scale of phase separation associated with nanostructured networks as well as in the porosity scale of (nano)porous materials derived therefrom. Indeed, we find that the quantitative extraction of uncrosslinked oligoesters from semi-IPNs allows for the elaboration of nanoporous networks with pore diameters lower than 150 nm, provided that a high miscibility between both partners in semi-IPN precursors is attained, i.e. when using the lower molar mass oligoester. Alternately, the total hydrolysis of the polyester subnetwork associated with IPNs offers more versatility, since nanoporous networks can be obtained with a pore size range of 20-150 nm, regardless of the oligoester nature and molar mass in IPN precursors.

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Preparation of polymeric porous materials by interparticle crosslinking

Cited by 15 publications

References 4 publications

Thermally reversible polymer gel for chondrocyte culture

Thermally reversible polymer gel for chondrocyte culture

Synthesis and characterization of highly porous poly(methacrylic-co-triethylene glycol dimethacrylate) by suspension polymerization

Oligoester-Derivatized (Semi-)Interpenetrating Polymer Networks as Nanostructured Precursors to Porous Materials with Tunable Porosity

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