Preparation of poly(vinylidene fluoride) microfiltration membrane with uniform surface-copolymerized poly(ethylene glycol) methacrylate and improvement of blood compatibility

Chang, Yung; Shih, Yu Ju; Ruaan, Ruoh‐Chyu; Higuchi, Akon; Chen, Wen Yih; Lai, Juin Yih

doi:10.1016/j.memsci.2007.10.024

Cited by 146 publications

(58 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PLA film showed characteristically high water contact angles (79°± 2°), as expected, while the water contact angle decreases with higher PEG content in the triblock copolymer films. This result is similar to that of many studies using PEG as a surface modifier [45,46]. It is interesting to note that the water contact angle of PLA/PEG physical blend film with PEG content of 50% (w/w) is 33.5°± 2°; while the PLA-PEG-PLA triblock copolymer films had a relatively high initial water contact angle of 55°± 5°(measured at 10 sec after water-film contact), a) The number after the 'PEG' denotes the PEG content (in percentage) in each copolymer.…”

Section: Hydrophilicity Of the Pla-peg-pla Triblock Copolymerssupporting

confidence: 92%

Fabrication of hydrophilic paclitaxel-loaded PLA-PEG-PLA microparticles via SEDS process

Ouyang

Kang

Yin

et al. 2009

Front. Mater. Sci. China

View full text Add to dashboard Cite

In this work, chemically bonded poly(D, Llactide)-polyethylene glycol-poly(D, L-lactide) (PLA-PEG-PLA) triblock copolymers with various PEG contents and PLA homopolymer were synthesized via melt polymerization, and were confirmed by FTIR and 1 H-NMR results. The molecular weight and polydispersity of the synthesized PLA and PLA-PEG-PLA copolymers were investigated by gel permeation chromatography. Hydrophilicity of the copolymers was identified by contact angle measurement. PLA-PEG-PLA and PLA microparticles loaded with and without PTX were then produced via solution enhanced dispersion by supercritical CO 2 (SEDS) process. The effect of the PEG content on the particle size distribution, morphology, drug load, and encapsulation efficiency of the fabricated microparticles was also studied. Results indicate that PLA and PLA-PEG-PLA microparticles all exhibit sphere-like shape with smooth surface, when PEG content is relatively low. The produced microparticles have narrow particle size distributions and small particle sizes. The drug load and encapsulation efficiency of the produced microparticles decreases with higher PEG content in the copolymer matrix. Moreover, high hydrophilicity is found when PEG is chemically attached to originally hydrophobic PLA, providing the produced drug-loaded microparticles with high hydrophilicity, biocompatibility, and prolonged circulation time, which are considered of vital importance for vesselcirculating drug delivery system.

show abstract

Section: Hydrophilicity Of the Pla-peg-pla Triblock Copolymerssupporting

confidence: 92%

Fabrication of hydrophilic paclitaxel-loaded PLA-PEG-PLA microparticles via SEDS process

Ouyang

Kang

Yin

et al. 2009

Front. Mater. Sci. China

View full text Add to dashboard Cite

show abstract

“…Many studies have reported that hydrophilic surfaces, such as those of hydrogels and PEG-grafted polymers, suppress protein adsorption and platelet adhesion [22,23]. In addition, hydrophilic polymers reduce the hydrophobic interaction between the surface and the proteins, suppressing the conformational changes that induce protein adsorption [24]. In this study, the surfaces of VI-g-PHO copolymers become more hydrophilic with more grafted VI groups.…”

Section: Blood Compatibility Of Vi-g-pho Copolymersmentioning

confidence: 77%

Biocompatibility and antimicrobial activity of poly(3-hydroxyoctanoate) grafted with vinylimidazole

Chung

Kim

et al. 2012

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

“…Os tempos de ensaio foram de 30 minutos, nas diferentes pressões. O fluxo de água permeada é dado pela Equação 1 [8] :…”

Section: Fluxo De áGua Permeadaunclassified

Preparação e caracterização de membranas assimétricas de poli (fluoreto de vinilideno) suportadas em poliéster - I: efeito do tratamento térmico nas propriedades das membranas

Thürmer¹,

Poletto²,

Marcolin³

et al. 2010

Polímeros

View full text Add to dashboard Cite

Resumo: O poli(fluoreto de vinilideno) (PVDF) é um polímero semicristalino contendo uma fase amorfa e uma cristalina. Essa característica é importante para o preparo de membranas assimétricas, pois a fase cristalina tem grande influência na formação da estrutura da membrana e a fase amorfa na porosidade. Membranas de PVDF foram preparadas pelo processo de inversão de fases e avaliadas quanto à permeabilidade e morfologia, bem como o efeito do tratamento térmico. Foram comparadas as seguintes membranas: membrana sem tratamento térmico, membrana com tratamento térmico e membrana comercial. Ensaios de resistência química, fluxo permeado de água a várias pressões, difusão de íons, Microscopia Eletrônica de Varredura (MEV), Calorimetria Exploratória Diferencial (DSC) e Análise Termogravimétrica (TGA) foram realizados para verificar o comportamento das membranas. Palavras-chave: PVDF, tratamento térmico, inversão de fases, membrana polimérica. Preparation and Characterization of Asymmetric Membranes of Poly (Vinylidene Fluoride) Supported in Polyester -I: Effect of Heat Treatment in the Properties of MembranesAbstract: Poly(Vinylidene Fluoride) (PVDF) is a semicrystalline polymer containing an amorphous and a crystalline phase. This characteristic is important for the preparation of asymmetric membranes, because the crystalline phase has great influence on the membranes structure, while the amorphous phase affects the porosity. PVDF membranes were prepared by the phase inversion process, which were then evaluated with regard to permeability and morphology, as well as the thermal treatment effect. The following membranes were compared: without thermal treatment, with thermal treatment and commercially-available membrane. The analysis of chemical resistance, water permeability flux to different pressures and diffusion of ions, in addition to studies with Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA), were performed to investigate the membranes properties.

show abstract

Preparation of poly(vinylidene fluoride) microfiltration membrane with uniform surface-copolymerized poly(ethylene glycol) methacrylate and improvement of blood compatibility

Cited by 146 publications

References 23 publications

Fabrication of hydrophilic paclitaxel-loaded PLA-PEG-PLA microparticles via SEDS process

Fabrication of hydrophilic paclitaxel-loaded PLA-PEG-PLA microparticles via SEDS process

Biocompatibility and antimicrobial activity of poly(3-hydroxyoctanoate) grafted with vinylimidazole

Preparação e caracterização de membranas assimétricas de poli (fluoreto de vinilideno) suportadas em poliéster - I: efeito do tratamento térmico nas propriedades das membranas

Contact Info

Product

Resources

About