Preparation of poly(3-hydroxybutyrate-co-hydroxyvalerate) films from halophilic archaea and their potential use in drug delivery

Danış, Özkan; Ogan, Ayşe; Tatlican, Pınar; Attar, Azade; Çakmakçı, Emrah; Mertoğlu, Bülent; Birbir, Meral

doi:10.1007/s00792-015-0735-4

Cited by 44 publications

(19 citation statements)

References 47 publications

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“…Danis et al [68] carried out similar experiments with five extremely halophilic archaeal isolates in order to trace the strain with the highest PHA-production capacity. PHA production of each isolate was individually examined on various inexpensive carbon sources such, e.g., sucrose, whey, corn starch, and waste of apples, melons and tomatoes.…”

Section: Discussionmentioning

confidence: 99%

Production of Polyhydroxyalkanoate (PHA) Biopolyesters by Extremophiles?

Koller¹

2017

MOJPS

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The article reviews the current state of knowledge of the production of polyhydroxyalkanoate (PHA) biopolyesters under extreme environmental conditions.Although PHA production by extremophiles is not realized yet at industrial scale, significant PHA accumulation under high salinity or extreme pH-or temperature conditions was reported for diverse representatives of the microbial domains of both Archaea and Bacteria. Several mechanisms were proposed to explain the mechanistic role of PHA and their monomers as microbial cell-and enzyme protective chaperons and the factors boosting PHA biosynthesis under environmental stress conditions. The potential of selected extremophile strains, isolated from extreme environments like glaciers, hot springs, saline brines, or from habitats highly polluted with heavy metals or solvents, for efficient future PHA production on an industrially relevant scale is assessed based on the basic data available in the scientific literature. The article reveals that, beside the needed optimization of other cost-decisive factors like inexpensive raw materials or efficient downstream processing, the application of extremophile production strains can drastically safe energy costs, are easily accessible towards long-term cultivation in chemostat processes, and therefore might pave the way towards cost-efficient PHA production, even combined with safe disposal of industrial waste streams. However, further challenges have still to be overcome in terms of strain improvement and process engineering aspects.

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Section: Discussionmentioning

confidence: 99%

Production of Polyhydroxyalkanoate (PHA) Biopolyesters by Extremophiles?

Koller¹

2017

MOJPS

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“…Pharmaceutical (drug delivery) (Nerland et al 2014;Gerard et al 2014;Nwachkwu et al 2010;Hatakka 2005;Danis et al 2015;Zembouai et al 2014)…”

Section: -175mentioning

confidence: 99%

Review on the current status of polymer degradation: a microbial approach

Pathak

Bithel

2017

Bioresour. Bioprocess.

557

241

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Inertness and the indiscriminate use of synthetic polymers leading to increased land and water pollution are of great concern. Plastic is the most useful synthetic polymer, employed in wide range of applications viz. the packaging industries, agriculture, household practices, etc. Unpredicted use of synthetic polymers is leading towards the accumulation of increased solid waste in the natural environment. This affects the natural system and creates various environmental hazards. Plastics are seen as an environmental threat because they are difficult to degrade. This review describes the occurrence and distribution of microbes that are involved in the degradation of both natural and synthetic polymers. Much interest is generated by the degradation of existing plastics using microorganisms. It seems that biological agents and their metabolic enzymes can be exploited as a potent tool for polymer degradation. Bacterial and fungal species are the most abundant biological agents found in nature and have distinct degradation abilities for natural and synthetic polymers.

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“…haloterrestris ), and Halopiger ( Hpg. aswanensis ) [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Among the halophilic bacteria, members of the genus Halomonas ( H. boliviensis ) are known to synthesize a large amount of PHA from a variety of substrates such as glucose, maltose, starch hydrolysate, etc.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Sugarcane Bagasse by Halogeometricum borinquense Strain E3 for Biosynthesis of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Salgaonkar

Bragança

2017

Bioengineering

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Sugarcane bagasse (SCB), one of the major lignocellulosic agro-industrial waste products, was used as a substrate for biosynthesis of polyhydroxyalkanoates (PHA) by halophilic archaea. Among the various wild-type halophilic archaeal strains screened, Halogeometricum borinquense strain E3 showed better growth and PHA accumulation as compared to Haloferaxvolcanii strain BBK2, Haloarcula japonica strain BS2, and Halococcus salifodinae strain BK6. Growth kinetics and bioprocess parameters revealed the maximum PHA accumulated by strain E3 to be 50.4 ± 0.1 and 45.7 ± 0.19 (%) with specific productivity (qp) of 3.0 and 2.7 (mg/g/h) using NaCl synthetic medium supplemented with 25% and 50% SCB hydrolysate, respectively. PHAs synthesized by strain E3 were recovered in chloroform using a Soxhlet apparatus. Characterization of the polymer using crotonic acid assay, X-ray diffraction (XRD), differential scanning calorimeter (DSC), Fourier transform infrared (FT-IR), and proton nuclear magnetic resonance (1H-NMR) spectroscopy analysis revealed the polymer obtained from SCB hydrolysate to be a co-polymer of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] comprising of 13.29 mol % 3HV units.

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Preparation of poly(3-hydroxybutyrate-co-hydroxyvalerate) films from halophilic archaea and their potential use in drug delivery

Cited by 44 publications

References 47 publications

Production of Polyhydroxyalkanoate (PHA) Biopolyesters by Extremophiles?

Production of Polyhydroxyalkanoate (PHA) Biopolyesters by Extremophiles?

Review on the current status of polymer degradation: a microbial approach

Utilization of Sugarcane Bagasse by Halogeometricum borinquense Strain E3 for Biosynthesis of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

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