Preparation of pH-Responsive Poly(aspartic acid) Nanogels in Inverse Emulsion

Krisch, Enikő; Szilágyi, András

doi:10.3311/ppch.9788

Cited by 16 publications

(20 citation statements)

References 27 publications

(35 reference statements)

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“…Gelation time can be adjusted by the amount of cross‐linker, but usually there is a critical concentration of cross‐linker for gelation. As a rule of thumb, one can say that the more cross‐linker is mixed in, the faster the gelation gets, although properties of gels (such as elasticity) also change with the amount of cross‐linker …”

Section: Resultsmentioning

confidence: 99%

“…As a rule of thumb, one can say that the more crosslinker is mixed in, the faster the gelation gets, although properties of gels (such as elasticity) also change with the amount of cross-linker. [20] In our case, instead of varying the concentration of THD in core solution, the amount of cross-linker (0.5 m THD in DMF solution) was changed by applying different feeding rates. Since the feeding rate of shell polymer solution was fixed, by varying the core feeding rate, the ratio of feeding rate between core and shell was varied as well (Table S1, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Poly(amino acid)‐Based Gel Fibers with pH Responsivity by Coaxial Reactive Electrospinning

Molnár

Jedlovszky-Hajdú

Zrı́nyi

et al. 2017

Macromol. Rapid Commun.

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Electrospinning is a well-known technique for the preparation of scaffolds for biomedical applications. In this work, a continuous electrospinning method for gel fiber preparation is presented without a spinning window. As proof of concept, the preparation of poly(aspartic acid)-based hydrogel fibers and their properties are described by using poly(succinimide) as shell polymer and 2,2,4(2,4,4)-trimethyl-1,6-hexanediamine as cross-linker in the core of the nozzle. Cross-linking takes place as the two solutions get in contact at the tip of the nozzle. The impact of solution concentrations and feeding rates on fiber morphology, proof of the presence of cross-links as well as pH sensitivity after the transformation of the poly(succinimide)-based material to poly(aspartic acid) is presented.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Poly(amino acid)‐Based Gel Fibers with pH Responsivity by Coaxial Reactive Electrospinning

Molnár

Jedlovszky-Hajdú

Zrı́nyi

et al. 2017

Macromol. Rapid Commun.

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“…PASP gels showing volume change upon redox stimulus were synthesized by using a non-redox sensitive cross-linker molecule together with disulphides [31,32]. Although the latter type of gels showed reversible redoxresponse, their use as drug formulation is limited as the synthesis was done in non-aqueous medium which makes the encapsulation of drugs and the preparation of nanogels difficult [33]. Drug encapsulation and release were not studied in those papers.…”

Section: Introductionmentioning

confidence: 99%

Poly(aspartic acid) hydrogels showing reversible volume change upon redox stimulus

Krisch

Gyarmati

Barczikai

et al. 2018

European Polymer Journal

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Redox and pH responsive hydrogels were synthesized, which can serve as matrices for smart drug delivery systems exploiting the redox and pH gradients in the human body. Water soluble thiolated poly(aspartic acid), a biocompatible synthetic polymer, enables us to crosslink in water with a non-cleavable cross-linker, poly(ethylene glycol) diglycidyl ether. The permanent cross-linker establishes stable polymer hydrogels regardless of the redox environment, thus the gels swell but do not dissolve upon redox stimuli. The reversible response upon redox stimulus was induced by thiol-disulphide transformation inside the hydrogel. The degree of swelling and the stiffness of the macroscopic hydrogels were controlled by their chemical composition including thiol content and cross-linking ratio as well as the redox state of the hydrogels. The degree of swelling of the hydrogels showed strong pH dependence due to the polyelectrolyte nature of the polymer network. Release of a macromolecular model drug was considerably faster in reducing than in oxidising environment, which indicates the potential use of the synthesized hydrogels as redox responsive drug delivery systems. Nanogels were prepared in water-in-oil emulsion and displayed redox-responsive properties. The hydrodynamic diameter of the nanogels strongly increased upon the cleavage of the disulphide linkages in reducing solution without the disruption of the gels.

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“…Nanogels, physically or chemically crosslinked hydrogel nanoparticles, can be prepared by the top–down or the bottom–up approach . Such strategies employ disintegration techniques, of physical association, and a free or controlled radical polymerization including inverse miniemulsion, inverse microemulsion or precipitation, reversible addition fragmentation chain transfer, or atom transfer radical polymerization …”

Section: Introductionmentioning

confidence: 99%

“…3 Such strategies employ disintegration techniques, of physical association, and a free or controlled radical polymerization including inverse miniemulsion, inverse microemulsion or precipitation, reversible addition fragmentation chain transfer, or atom transfer radical polymerization. [3][4][5][6][7][8][9] With regard to chemically crosslinked nanogels, the enzyme-mediated crosslinking strategy has been shown to be a very interesting alternative form of chemical crosslinking. Using this method for conventional injectable hydrogel formation, it was shown that the physicochemical properties including gelation time, mechanical strength, swelling ratio, and porosity could be well adjusted.…”

Section: Introductionmentioning

confidence: 99%

Colloidally stable polypeptide‐based nanogel: Study of enzyme‐mediated nanogelation in inverse miniemulsion

Dvořáková

Šálek

Korecká

et al. 2019

J of Applied Polymer Sci

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The current work presents a pivotal study of the nanogelation of the linear poly(N5‐2‐hydroxypropyl‐L‐glutamine) polymer precursor containing tyramine (TYR) units in an inverse miniemulsion by horseradish peroxidase/H2O2‐mediated crosslinking. The effects of various nH2O2/nTYR ratios on the kinetics of nanogelation in the inverse miniemulsion and on the reaction time are investigated by linear sweep voltammetry, while the formation of dityramine crosslinking is explored by fluorescence spectroscopy. The study is completed using dynamic light scattering measurements, nanoparticle tracking analysis, and cryogenic transmission electron microscopy to acquire comprehensive information about the formed nanoparticulate systems. With the optimal ratio nH2O2/nTYR = 2, the strategy yields in the high‐quality ~ 130 nm poly(amino acid)‐based nanogel, which is prepared in 2 h. The nanogel is colloidally stable under different temperature and pH conditions for over 168 h. Moreover, the demonstrated nanogel is noncytotoxic for HeLa cells and human primary fibroblasts and is quickly enzymatically hydrolyzed into small fragments during a biodegradation study in human blood plasma. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48725.

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Preparation of pH-Responsive Poly(aspartic acid) Nanogels in Inverse Emulsion

Cited by 16 publications

References 27 publications

Poly(amino acid)‐Based Gel Fibers with pH Responsivity by Coaxial Reactive Electrospinning

Poly(amino acid)‐Based Gel Fibers with pH Responsivity by Coaxial Reactive Electrospinning

Poly(aspartic acid) hydrogels showing reversible volume change upon redox stimulus

Colloidally stable polypeptide‐based nanogel: Study of enzyme‐mediated nanogelation in inverse miniemulsion

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