Preparation of peptide-loaded polymer microparticles using supercritical carbon dioxide

Jung, In Il; Haam, Seoungjoo; Lim, Gio‐Bin; Ryu, Jong Hoon

doi:10.1007/s12257-011-0241-1

Cited by 11 publications

(10 citation statements)

References 37 publications

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“…iii) Particles from Gas Saturated Solutions (PGSS): is a process similar to RESS but in this case the substances are not soluble in the supercritical fluid but they are melted forming a dispersion; then, the Joule-Thomsom effect associated to depressurization cools the dispersion and small particles are obtained 115 . iv) Aerosol solvent extraction system (ASES): drug and polymer are dissolved or dispersed in an organic solvent which is sprayed into a supercritical phase; the organic solvent, soluble in the supercritical gas phase, is extracted resulting in the formation of solid microparticles of drug+polymer 116 .…”

Section: Pharmaceuticalmentioning

confidence: 99%

Membrane Separation

Voutsas¹

2014

Food Engineering Handbook

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Supercritical fluid extraction (SFE) has become one of the most popular green extraction techniques nowadays since it has demonstrated many advantages compared to traditional or classical extraction processes. Aspects such as improved selectivity, higher extraction yields, better fractionation capabilities and lower environmental impacts have been crucialto the important growth of SFE. In this chapter, fundamentals of SFE are presented together with the most important variables that can affect the extraction process and how to tune them. Moreover, interesting and new applications in different areas such as food science, pharmaceutical and others like, for instance, heavy metals recovery are presented.

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Section: Pharmaceuticalmentioning

confidence: 99%

Membrane Separation

Voutsas¹

2014

Food Engineering Handbook

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“…Regarding the pharmaceutical field, using the SAS process, up to now, micronized drug particles and several polymer/active compound composites have been proposed for different biomedical applications [31][32][33][34][35]. Indeed, SAS precipitated particles can be used for drug delivery by oral, parenteral, transdermal, or topical routes [2,[36][37][38][39][40][41][42]. The versatile SAS particles can be used in powder form for the oral administration of composites or the preparation of aerosol formulations, mainly for the treatment of respiratory diseases; they can also be used for the production of medicated patches or active topical gels, by incorporating nanoparticles/microparticles into various types of dressings, supports or pomades, respectively.…”

Section: Introductionmentioning

confidence: 99%

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

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The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.

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“…[34] andLee et al (2008) [35] attempted to enhance the mass transfer of the solute solution and the supercritical fluids phase, known as the SAS-EM process. The SAS-EM process produced quite fine nanoparticles due to the enhancement of the mass transfer effect and relatively high encapsulation efficiencies between 80 and 90%[34, 35].A study conducted byJung et al (2012)…”

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confidence: 99%

Formation of Nanocarrier Systems by Dense Gas Processing

2014

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Nanocarrier systems, such as liposomes, polymersomes, and micelles, find applications in the delivery of a wide range of compounds, including targeted delivery of pharmaceuticals. Nanocarrier systems have the ability to increase the bioavailability, reduce toxicity, and avoid undesirable interactions of active pharmaceutical ingredients. In this work, a novel dense gas technique known as depressurization of an expanded solution into aqueous media (DESAM) was used to produce different types of nanocarrier systems. The effects of using different types of dense gases and different operating temperatures were investigated. Encapsulation of hydrophilic compounds in the vesicles (liposomes and polymersomes) was also studied. The highest encapsulation efficiencies in liposomes and polymersomes achieved were 10.2 and 9.7%, respectively. The DESAM process was also able to reduce the residual solvent content in the product to 2.2% (v/v), which is significantly lower than the solvent residual levels reported for conventional processing.

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Preparation of peptide-loaded polymer microparticles using supercritical carbon dioxide

Cited by 11 publications

References 37 publications

Membrane Separation

Membrane Separation

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Formation of Nanocarrier Systems by Dense Gas Processing

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