Preparation of novel stable microbicidal hydrogel films as potential wound dressing

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

“…The accumulation of wounds ultimately causes an increase in bacterial growth. Thus, it has been recommended that a WVTR of approximately 2000 ± 500 g·m –2 ·day –1 would provide a suitable moisture level to prevent build-up of the exudates and excessive dehydration on the wound area. , It can also maintain a comfortable moisture content for the proliferation of epidermal cells and fibroblasts for wound healing Figure depicts the effect of the PCLDA content on the WVTR.…”

“…51,52 It can also maintain a comfortable moisture content for the proliferation of epidermal cells and fibroblasts for wound healing. 53 Figure 14 depicts the effect of the PCLDA content on the WVTR. The WVTR of the prepared hydrogel was not significantly different (1915−2196 g•m −2 •day −1 ) with the addition of PCLDA.…”

Advances in modified hyaluronic acid-based hydrogels for skin wound healing

“…167–171,251 Through careful selection of monomers and crosslinking agents, the hydrophilicity and porosity of the hydrogel was found to have an excellent effect in antibacterial applications. 172 HA-based hydrogels with antibacterial activity can be roughly divided into the following types according to the different antibacterial components: inorganic nanoparticles with antibacterial function (such as Ag nanoparticles, 173,174 ZnO 175 ), loading with antibiotic drugs, for example, antibiotic (gentamicin, 176 ampicillin 177 ), antimicrobial peptides(SWLSKTAKKLFKKIPKKIPKKRFPRPRPWPRPNMI-NH2, 178 KK(SLKL)3KK 179 ), antibacterial compounds (curcumin, 100 chlorhexidine diacetate, 153 polyarginine 180 ), materials capable of generating reactive oxygen species with bactericidal ability (Ag ions, 181 Zr-based porphyrinic metal−organic framework, 182 silver nanoparticles 183 ), and hydrogels that possess inherent antibacterial ability (bionic hydrogels obtained via dual-crosslinking between oxidized HA (HA-CHO) and dopa-grafted ε-polylysine, 184 a hydrogel with thiol derivatised HA and maleilated chitosan, 185 or a hydrogel made of HA, poly(vinylphosphonic acid), and chitosan 186 ).…”

Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

“…Chitosan can only dissolve under acidic conditions and play an antibacterial role, significantly restricting its application in a biological environment due to its poor water solubility [ 134 ]. However, the antibacterial properties of chitosan are weak, and chitosan derivatives have difficulty meeting the complex antibacterial requirements in clinical practice [ 136 ]. Therefore, combining chitosan with other agents is necessary to enhance its antibacterial properties.…”

“…Citral was reacted with polycationic CS and polyanionic carboxymethyl (CMC) to synthesize polyelectrolyte composite hydrogel microspheres [ 60 ]. A novel antibacterial membrane (HA-CC-GS) was developed by the intermolecular covalent bonding of hyaluronic acid, carboxylated CS, and gentamicin, which have good hygroscopic properties, suitable water vapor permeability rates (WVPR), excellent mechanical properties, and significant resistance to enzymatic hydrolysis [ 136 ]. The hydrogel can potentially be applied to wounds in the internal environment.…”