Preparation of New Complexes of Fe(II), Co(II), Ni(II) and Cu(II) with Mixed Ligands of Ciprofloxacin or Levofloxacin with Eugenol and Study of Their Chemical and Physical Properties

Abstract

Eight new mixed ligands metal complexes have been prepared by the reaction of Fe(II), Co(II), Ni(II) and Cu(II) with (1:1:1 molar ratio) of ciprofloxacin -eugenol or levofloxacin -eugenol mixed ligands in alkaline medium. The coordination of the mixed ligands toward metal ions has been anticipated in the light of elemental analysis, molar conductance, spectral infrared (IR), ultraviolet-visible (UV-Vis) and magnetic measurements were bidentate ligands. Electronic and magnetic data suggested the octahedral configuration for all these new complexes. The molar conductance data for the metal complexes show nonelectrolytic behaviour in DMF solvent and non-electrolytic properties, also they were no conducting electrical current. The biological activity of the prepared complexes was studied with positive and negative Gram-positive bacteria and good antibacterial results.

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

“…It is known that the effect of the sulfonic acid group is large, so it gave excellent results if compared with the known antibiotics, where the compounds showed 7-11 higher efficacy than those used (28)(29)(30) . Table (7) shows the values obtained by studying the biological activity of the prepared compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Table (7): biological activity of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)…”

“…Table (7) shows the values obtained by studying the biological activity of the prepared compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Table (7): biological activity of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)…”

“…Sulfanilic acid is one of the most important types of organic sulfur compounds, which was used as the main nucleus in the preparation of many types of dyes and their derivatives (1,2) , especially the mineral formazan dye (3) . Since this substance contains an amino group that can be converted to an (Azo) group (4) , in addition to its use in the preparation of benzodiazepine substitutes through reaction of O-phenyl diamine with ketones (5) . The Sulfanilic acid derivatives have been used in the manufacture of materials for use in solar energy applications (6).…”

“…infrared spectrum and Table(6) nuclear magnetic resonance. Table(3): IR Spectral of Schiff base compounds(1)(2)(3)(4)(5) …”