Preparation of Monolithic Imprinted Stationary Phase for Clenbuterol by In Situ Polymerization and Application in Biological Samples Pretreatment

Luo, Yu; Huang, Ping; Fu, Qiang; Du, Wei; Sun, Shih‐Jieh; Li, Ya; Li, Meng; Chang, Chun

doi:10.1007/s10337-011-2129-9

Cited by 17 publications

(6 citation statements)

References 24 publications

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“…It was especially notable that the difference of the adsorption capacity ( Q t ) became enlarged with the increase of the RAC concentration within the observed range. The binding isotherms could be estimated by application of the Scatchard analysis model [36] , [37] , i.e. Q/C e =( Q max − Q )/ K d , where Q max is the maximum adsorption capacity, K d is the equilibrium dissociation constant, and C e represents the equilibrium concentration of RAC in solution, respectively.…”

Section: Resultsmentioning

confidence: 99%

Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers

et al. 2012

Journal of Pharmaceutical Analysis

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In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentration with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples.

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Section: Resultsmentioning

confidence: 99%

Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers

et al. 2012

Journal of Pharmaceutical Analysis

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“…XRD is used to analyze the diffraction spectroscopy of materials. Generally, a wide-angle XRD pattern indicates the presence of magnetic solids and a low-angle pattern indicates the pore structure of porous magnetic materials [ 94 ]. The XRD results observe the shape of the Fe 3 O 4 diffraction peak and compare this with the standard Fe 3 O 4 diffraction form.…”

Section: Characterization Of Mmipsmentioning

confidence: 99%

Magnetic Molecularly Imprinted Polymers: An Update on Their Use in the Separation of Active Compounds from Natural Products

et al. 2022

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During the last few years, separation techniques using molecularly imprinted polymers (MIPs) have been developed, making breakthroughs using magnetic properties. Compared to conventional MIPs, magnetic molecularly imprinted polymers (MMIPs) have advantages in sample pretreatment due to their high specificity and selectivity towards analytes as a result of their larger specific surface areas and highly accessible specific binding sites. The techniques of isolation of active compounds from natural products usually require very long process times and low compound yields. When MMIPs are used in sample separation as Solid Phase Extraction (SPE) sorbents, the MMIPs are introduced into the dissolved sample and spread evenly, and they form bonds between the analyte and the MMIPs, which are then separated from the sample matrix using an external magnetic field. This process of separating analytes from the sample matrix makes the separation technique with MMIPs very simple and easy. This review discusses how to synthesize MMIPs, which factors must be considered in their synthesis, and their application in the separation of active compounds from natural products. MMIPs with magnetic core-shells made by co-precipitation can be a good choice for further development due to the high synthesis yield. Further optimization of the factors affecting the size and distribution of magnetic core-shell particles can obtain higher synthesis yields of MMIPs with higher adsorption capacity and selectivity. Thus, they can isolate target compounds from natural plants in high yields and purity.

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“…MIPs offer a number of advantages, in particularly long‐term storage stability, potential re‐usability, resistance to microbial damage, facile integration into transducers , low cost, ease of preparation, and finally, comparable affinity and recognition ability for the target substrate . MIPs have a wide range of applications such as solid phase extraction ,, stationary phases in high performance liquid chromatography ,, capillary electrochomatography drug delivery , and sensors ,.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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A molecularly imprinted polymer (MIP) was rationally synthesized with the aid of computer based studies. The computational studies were used to screen for the most suitable template to functional monomer molar ratio. Two functional monomers were involved in the study (methacrylic acid and 4‐vinylpyridine). Four MIP ratios were synthesized in accordance with the results of the computational studies and their performance was evaluated using equilibrium rebinding assays. The MIP with the best performance was used as an additive in carbon paste electrodes for the voltammetric determination of valaciclovir (VCV). Following the optimization of voltammetric parameters, a linear response was obtained in the range of 1.0x10−6–7.0x10−4 M with a limit of detection at 4.45x10−7 M. The MIP modified carbon paste electrode was successfully applied for the determination of VCV in pure solutions and dosage form.

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Preparation of Monolithic Imprinted Stationary Phase for Clenbuterol by In Situ Polymerization and Application in Biological Samples Pretreatment

Cited by 17 publications

References 24 publications

Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers

Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers

Magnetic Molecularly Imprinted Polymers: An Update on Their Use in the Separation of Active Compounds from Natural Products

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

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