Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility

Abstract

Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by 1 H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification.

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

“…Lately, heparin-mimic compounds with a better control over structure, sulfation and purity have been developed. Lin et al [ 92 ] developed PSF functionalized with sulfonated citric chitosan, which has a structure and groups similar to heparin to improve the hemocompatibility of PSF. Sulfonated citric chitosan was obtained via N -acylation and sulfonation to take the negative carboxyl and sulfonic groups and attach them to chloroacylated PSF, which previously was treated by introducing –COCH 2 Cl groups into the PSF, followed by the preparation of chloroacylated membranes via the phase separation method.…”