Preparation of lignin-based hydrogels, their properties and applications

Mondal, Ajoy Kanti; Uddin, Md. Tushar; Sujan, S. M. A.; Tang, Zuwu; Alemu, Digafe; Begum, Hosne Ara; Li, Jianguo; Huang, Fang; Ni, Yonghao

doi:10.1016/j.ijbiomac.2023.125580

Cited by 10 publications

(3 citation statements)

References 174 publications

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“…Its cytotoxicity depends on the process of chemical extraction, as well as antioxidant and antimicrobial properties. The application of lignin in the biomedical domain can be summarized as follows: for wound healing as hydrogelbased materials, in tissue engineering as hydrogels and nanofibers, in drug delivery due to its ability to encapsulate hydrophobic/lipophilic drugs for oncological therapy [100][101][102][103][104][105].…”

Section: Gumsmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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Section: Gumsmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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“…[115] They included drug delivery, [116] tissue engineering, [117] and antibacterial agents. [118] Juan et al [119] obtained lignin based composites with antimicrobial and antioxidant properties by combining poly(butylene succinate) (PBS), a biocompatible/biodegradable polymer. The results suggested that all the materials were capable of reducing (2,2-Diphenyl-1-picrylhydrazyl) DPPH concentrations up to 80 % in < 5 h. In addition, lignin-containing composites showed good resistance to adherence of the common nosocomial pathogen, Staphylococcus aureus.…”

Section: Biomedical Materialsmentioning

confidence: 99%

Functional Lignin‐based Polymers: Isolation, Synthetic Methods and High‐valued Applications

Shao,

Liu,

Wang

et al. 2023

ChemistrySelect

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As a major component of lignocellulosic biomass, lignin has lots of fascinating properties, such as regeneration, biocompatibility, antioxidant, hydrophilicity, unique aromatic structure, and various functional groups, which make them become interesting natural polymer raw material, and attracted more and more attention. In particular, the rich functional groups of lignin can be easily functionalized through various synthesis methods, which can endow lignin‐based polymers with new structure and function. These functional lignin‐based polymers are widely used in environmental remediation, smart hydrogel materials, catalysis, biomedical, etc. However, its various sources and types, the complex structure, relatively weak chemical reactivity, the unstable processing property, and few high value‐added products limited their practical applications. With the development of lignin varieties, modified reagent, synthesis methods, and polymerization process, many works had been published for the synthesis and application of lignin‐based polymers. In this review, the lignin isolation, modification strategies, polymerization method and process, and the promising applications were summarized and analyzed in recent years. Specially, the recent advances in the preparation of high excellent adsorbents from deconstructed lignin products are highlighted from the synthesis methods and adsorption mechanism perspective. Finally, we discussed these challenges in the green and controllable synthesis of lignin‐based polymers, and prospected their functional applications.

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“…Hydrogels are a class of cross-linked, polymer-based, and hydrophilic three-dimensional (3D) networks comprising a large quantity of water without being dissolved, − which are promising candidates in various biomedical fields, such as tissue engineering , and drug delivery or release. − Self-healable and injectable hydrogels have some special properties compared with conventional injectable hydrogels because they can be injected by employing force and rapid recovery to the integral hydrogel phase . Self-healable and injectable hydrogels can automatically recover damage and sustain their lifetime during application .…”

Section: Introductionmentioning

confidence: 99%

Biocompatible, Injectable, and Self-Healing Poly(N-vinylpyrrolidone)/Carboxymethyl Cellulose Hydrogel for Drug Release

Tang,

Yang,

Pan

et al. 2024

ACS Omega

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Hydrogels have drawn intensive attention as fascinating materials for biomedicine. However, fabricating hydrogels with injectable and self-healing properties remains a challenge. Herein, we reported a biocompatible poly(N-vinylpyrrolidone)/carboxymethyl cellulose (PVP/ CMC) hydrogel with excellent injectable and self-healing properties. The PVP/CMC hydrogel exhibits good biocompatible, injectable, and selfhealing properties. The sol−gel transition of PVP/CMC hydrogels demonstrates an outstanding self-healing behavior, and the bisected hydrogels can self-heal within 30 s. The hydrogels have a good swelling ratio, and the swelling ratio increases with increasing amount of CMC in PVP and reaches a maximum of 2850% at a 1.0:1.5 PVP and CMC ratio. In addition, the hydrogel possesses excellent drug release capacity, and its drug release rate reaches 70%. Moreover, the release of 4-aminosalicylic acid (4-ASA) in the hydrogel can be controlled by adjusting the proportion of the hydrogel. The PVP/CMC hydrogel with excellent biocompatible, injectable, and self-healing properties has great potential for applications in drug release.

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Preparation of lignin-based hydrogels, their properties and applications

Cited by 10 publications

References 174 publications

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Functional Lignin‐based Polymers: Isolation, Synthetic Methods and High‐valued Applications

Biocompatible, Injectable, and Self-Healing Poly(N-vinylpyrrolidone)/Carboxymethyl Cellulose Hydrogel for Drug Release

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