Biocompatible, Injectable, and Self-Healing Poly(N-vinylpyrrolidone)/Carboxymethyl Cellulose Hydrogel for Drug Release

Abstract

Hydrogels have drawn intensive attention as fascinating materials for biomedicine. However, fabricating hydrogels with injectable and self-healing properties remains a challenge. Herein, we reported a biocompatible poly(N-vinylpyrrolidone)/carboxymethyl cellulose (PVP/ CMC) hydrogel with excellent injectable and self-healing properties. The PVP/CMC hydrogel exhibits good biocompatible, injectable, and selfhealing properties. The sol−gel transition of PVP/CMC hydrogels demonstrates an outstanding self-healing behavior, and the bisected hydrogels can self-heal within 30 s. The hydrogels have a good swelling ratio, and the swelling ratio increases with increasing amount of CMC in PVP and reaches a maximum of 2850% at a 1.0:1.5 PVP and CMC ratio. In addition, the hydrogel possesses excellent drug release capacity, and its drug release rate reaches 70%. Moreover, the release of 4-aminosalicylic acid (4-ASA) in the hydrogel can be controlled by adjusting the proportion of the hydrogel. The PVP/CMC hydrogel with excellent biocompatible, injectable, and self-healing properties has great potential for applications in drug release.

Fabrication of NIR-II-Responsive Polydextran Aldehyde/Gelatin/Gold Nanoparticle-Decorated Graphene Oxide Nanocomposite Hydrogels for Antibacterial Applications

“…Hydrogels containing neomycin (1 wt %) were prepared for study: PDA/Gel/Neo, PDA/Gel/GO1/Neo, PDA/Gel/GOAu1/Neo, and PDA/Gel/GOAu4/Neo with a load rate of 3.2 ± 0.6, 3.8 ± 0.6, 4.0 ± 0.4, and 2.7 ± 0.1%, respectively, calculated based on the following equation: Drug load rate = Mass of loaded drug Mass of drug‐loaded hydrogel × 100 % …”