Preparation of itraconazole/HP-β-CD inclusion complexes using supercritical aerosol solvent extraction system and their dissolution characteristics

Lee, Sang-Yun; Jung, In-Il; Kim, Jeong‐Kyu; Lim, Gio‐Bin; Ryu, Jong-Hoon

doi:10.1016/j.supflu.2007.09.006

Cited by 45 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the formation processes of drug‐CD complexes based on the use of supercritical fluids as solvents or antisolvents for poorly water‐soluble active pharmaceutical ingredients have been introduced as a viable means of increasing the solubility in water to improve the controlling particle formation and increase bioavailability (Kamihira et al . 1990; Lee et al . 2008).…”

Section: Introductionmentioning

confidence: 99%

PREPARATION AND CHARACTERIZATION OF RESVERATROL/HYDROXYPROPYL‐β‐CYCLODEXTRIN INCLUSION COMPLEX USING SUPERCRITICAL ANTISOLVENT TECHNOLOGY

Zhou

Wang

Guo

et al. 2011

J Food Process Engineering

View full text Add to dashboard Cite

The inclusion complex of resveratrol (RV) and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) prepared by supercritical antisolvent (SAS) process was investigated to improve its aqueous solubility. The phase solubility diagram with HP‐β‐CD was classified as AL type, and the calculated apparent complexation constant (KC) was 5,988 M−1 at 298K. Inclusion complexes were analyzed by differential scanning calorimetry (DSC), powder X‐ray diffractometry (PXRD), Fourier‐transform infrared spectroscopy (FT‐IR) and scanning electron microscopy (SEM). No endothermic and characteristic diffraction peaks corresponding to RV were observed for the inclusion complex in DSC and PXRD. FT‐IR study demonstrated the presence of intermolecular hydrogen bonds between RV and HP‐β‐CD in inclusion complex, resulting in the formation of amorphous form. Furthermore, the SAS‐processed RV/ HP‐β‐CD powders showed a significant enhancement in the solubility of RV (up to 25.13 mg/mL) in an aqueous medium. The percent dissolution of RV increased considerably and about 100% of RV was dissolved within 5–10 min. PRACTICAL APPLICATIONS In this study, the supercritical antisolvent (SAS) process was effectively utilized to prepare solid‐state inclusion complexes of resveratrol (RV) and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD). The SAS‐processed RV/HP‐β‐CD powders showed a significant enhancement in the solubility of RV (up to 25.13 mg/mL) in an aqueous medium. The percent dissolution of RV increased considerably and about 100% of RV was dissolved within 5–10 min. This work thoroughly overcomes the high hydrophobicity and sensitivity of resveratrol to air and light, so that obviously enlarges the application in pharmaceutical, chemical, food and cosmetic industries.

show abstract

Section: Introductionmentioning

confidence: 99%

PREPARATION AND CHARACTERIZATION OF RESVERATROL/HYDROXYPROPYL‐β‐CYCLODEXTRIN INCLUSION COMPLEX USING SUPERCRITICAL ANTISOLVENT TECHNOLOGY

Zhou

Wang

Guo

et al. 2011

J Food Process Engineering

View full text Add to dashboard Cite

show abstract

“…Rocco (2007) patented a method for sterilizing glucocorticosteroids by SC-CO 2 using treatment at 125°C and 8 MPa for 25 min. Also the feasibility of SC-CO 2 processes to produce inclusion complexes between drugs and cyclodextrins in the solid-state has been studied (Lee et al, 2008). The residual solvent removal by SC-CO 2 exploits the great diffusivity of the compressed gas as well as the easy evaporation of organic solvent into the supercritical phase.…”

Section: Applications Of Sc-co 2 In Pharmaceutical and Sterilization mentioning

confidence: 99%

Application of supercritical CO2 in lipid extraction – A review

Ferdosh

Zaidul

Selamat

et al. 2009

Journal of Food Engineering

543

251

View full text Add to dashboard Cite

a b s t r a c tSupercritical fluid extraction (SFE) offers an alternative method to conventional extraction of fatty acids. SFE was developed for analytical application in the mid-1980s in response to the desire to reduce the use of organic solvents in the laboratory environment, and it is now becoming a standard method for the extraction, fractionation, refinement and deodorization of lipids or essential oils containing sample matrices at the industrial scale. This paper reviews applications of supercritical fluid technology in fatty acid/lipid extraction using carbon dioxide. Carbon dioxide is an ideal supercritical fluid because of its environmentally benign, non-toxic, non-flammable, non-polluting, recoverable characteristics and its ability to solubilise lipophilic substances. A summary of commercial applications and examples of recent developments of SFE in the food processing industry are also reviewed.

show abstract

“…To improve the solubility of bioproducts, various techniques such as solid dispersion and inclusion complexations, have been developed. Among these techniques, inclusion complexation with cyclodextrins (CDs) and their derivatives are the most useful method to enhance the aqueous solubility of poorly water‐soluble bioproducts (Lee and others 2008). …”

Section: Introductionmentioning

confidence: 99%

Formation of β‐Cyclodextrin Inclusion Enhances the Stability and Aqueous Solubility of Natural Borneol

Su¹,

Chen²,

Li³

et al. 2012

Journal of Food Science

View full text Add to dashboard Cite

Natural borneol (NB) has the potential to be widely used in the fields of medical and functional food, due to its specificity. However, the disadvantages of unstability in the preparation and storage process due to its easy sublimation and the low water solubility limit its application. This research provides an effective way to improve the solubility and stability of NB by preparing NB/β-CD inclusion complex. Furthermore, theoretical basis is also provided for the application development of NB.

show abstract

Preparation of itraconazole/HP-β-CD inclusion complexes using supercritical aerosol solvent extraction system and their dissolution characteristics

Cited by 45 publications

References 34 publications

PREPARATION AND CHARACTERIZATION OF RESVERATROL/HYDROXYPROPYL‐β‐CYCLODEXTRIN INCLUSION COMPLEX USING SUPERCRITICAL ANTISOLVENT TECHNOLOGY

PREPARATION AND CHARACTERIZATION OF RESVERATROL/HYDROXYPROPYL‐β‐CYCLODEXTRIN INCLUSION COMPLEX USING SUPERCRITICAL ANTISOLVENT TECHNOLOGY

Application of supercritical CO2 in lipid extraction – A review

Formation of β‐Cyclodextrin Inclusion Enhances the Stability and Aqueous Solubility of Natural Borneol

Contact Info

Product

Resources

About