Formation of β‐Cyclodextrin Inclusion Enhances the Stability and Aqueous Solubility of Natural Borneol

Su, Jianyu; Chen, Jianping; Li, Lin; Li, Bing; Shi, Lei; Chen, Ling; Xu, Zhenbo

doi:10.1111/j.1750-3841.2012.02713.x

Cited by 30 publications

(11 citation statements)

References 22 publications

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“…Two types of borneol are described: synthetic and natural. Synthetic borneol is presented as a mixture of D/L‐borneol and isoborneol, while natural borneol is mostly composed of D‐borneol, with >95.0% in weight content, being steady and nontoxic .…”

Section: Introductionmentioning

confidence: 99%

New insights on relaxant effects of (—)‐borneol monoterpene in rat aortic rings

Santos

Ribeiro

Menezes

et al. 2018

Fundamemntal Clinical Pharma

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The monoterpene alcohol (−)‐borneol has many biological effects such as sedative, anti‐inflammatory, analgesic, anti‐nociceptive, antithrombotic and vasorelaxant effects. Our objective in this study was to investigate the mechanism of action of (−)‐borneol and determine its vasorelaxant effect. (−)‐Borneol was tested on isolated aortic rings contracted with PE (10−6 m). This study was performed in the absence or in the presence of endothelium, L‐NAME (100 μm), indomethacin (10 μm), TEA (1 and 10 mm), 4‐AP (1 mm) or glibenclamide (1 mm) to assess the participation of EDRF, nitric oxide, prostanoids and potassium channels on the relaxing effect of (−)‐borneol. In this work, (−)‐borneol induced a relaxant effect in aortic rings, with and without endothelium, in a concentration‐dependent manner. The pharmacological characterization obtained using L‐NAME, indomethacin, TEA, 4‐AP and glibenclamide demonstrates that the effect of (−)‐borneol was modified in the presence of L‐NAME, indomethacin and glibenclamide showing that these signal transduction pathways are involved in the relaxing effect of the monoterpene. (−)‐Borneol has a vasorelaxant effect that depends on the presence of vascular endothelium, with the participation of nitric oxide and prostanoids. Also, (−)‐borneol displayed a direct action on the vascular smooth muscle, greatly dependent on KATP channels.

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Section: Introductionmentioning

confidence: 99%

New insights on relaxant effects of (—)‐borneol monoterpene in rat aortic rings

Santos

Ribeiro

Menezes

et al. 2018

Fundamemntal Clinical Pharma

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“…The process of encapsulating curcumin molecules with cyclodextrin is generally to first prepare a solution of β-cyclodextrin, then directly add curcumin or an organic solvent solution of curcumin in proportion and mix them thoroughly. For obtaining a better embedding and solubilizing effect, appropriate solvent is also usually chosen to adjust the temperature and pH, ultrasonic assist and other methods are applied [26][27]. Studies have shown that the cyclodextrin inclusion compound can be prepared by applying saturated solution method to achieve the embedding of curcumin, and the cyclodextrin inclusion compound with curcumin can be well dispersed in water [28].…”

Section: Cyclodextrin Inclusion Compoundmentioning

confidence: 99%

Advance on the nano delivery system of curcumin

Tang

2020

E3S Web Conf.

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Curcumin has various physiological functions such as anti-oxidation, anti-cancer and prevention of Alzheimer's disease, but its poor water solubility and unstable physicochemical property limits the development and application of curcumin. The nano delivery carriers for curcumin prepared by nanotechnology can effectively solve these problems above. This paper summarized the research reports and literatures at home and abroad in recent years, categorized the nanocarriers of curcumin and analysed the definitions, preparation methods, properties and features, advantages and disadvantages of nano-emulsion, solid lipid particles, liposome, cyclodextrin inclusion compound respectively. In addition, this paper predicted application prospects of curcumin in the fields of food and medicine and provided references for the comprehensive development and utilization of curcumin.

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“…Some lubricant additives, due to their suitable molecular size and polarity [6,7] , may also be included by β-CD in aqueous solution. As additives carriers, the advantages of β-CD are its ability to protect additives against thermal or chemical degradation and especially oxidation efficiently [8][9][10] , and also reduce the pollutions on the environment. Most importantly, the physical state of liquid additives changes owing to the complication with β-CD.…”

Section: Introductionmentioning

confidence: 99%

Preparation and action mechanism of inclusion complex of β-cyclodextrin and sulfurized isobutylene as additives in solution of polyethylene glycol-600

Guan

et al. 2015

J. Wuhan Univ. Technol.-Mat. Sci. Edit.

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The inclusion complex of β-cyclodextrin (β-CD) and sulfurized isobutylene (T321) was prepared with a co-precipitation method. The tribological properties of the complex with different concentrations were investigated by a four-ball tester in the solution of polyethylene glycol-600 (PEG-600). The experimental results suggest that the complex exhibits better anti-friction and anti-wear properties than β-CD under different load conditions. The tribo-system shows the least friction coefficient when the concentration of the complex is 0.8%. During the friction process, the complex was decomposed into various molecular fragments and the T321 molecules were released onto the friction interface to provide effective lubrication. The XPS analytical results on the worn surfaces reveal that sulfide film formed by the released T321 plays a major role, and the iron alkoxide and carbon deposition films formed by the β-CD fragments have better anti-friction effect on the sulfide film surface. The interactions of different films result in the formation of a mixed boundary lubrication film.

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Formation of β‐Cyclodextrin Inclusion Enhances the Stability and Aqueous Solubility of Natural Borneol

Cited by 30 publications

References 22 publications

New insights on relaxant effects of (—)‐borneol monoterpene in rat aortic rings

New insights on relaxant effects of (—)‐borneol monoterpene in rat aortic rings

Advance on the nano delivery system of curcumin

Preparation and action mechanism of inclusion complex of β-cyclodextrin and sulfurized isobutylene as additives in solution of polyethylene glycol-600

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