[Retracted] Preparation of Iron Oxide and Titania‐Based Composite, Core‐Shell Populated, Nanoparticulates Material by Two‐Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer Agents

Abstract

Iron oxide and titania-based composite nanoparticles (NPs) populated with core-shell structures, as part of the mixture of the monometallic NPs, were prepared in water medium by the two-fluence LASER ablation technique by applying 30 and 60 mJ/cm2 LASER energy irradiations. The prepared monometallics, composite, and core-shell NPs structures were confirmed from the XRD, TEM, and EDX analyses, followed by the FE-SEM and UV absorptions. Optically, the NPs exhibited an increase in the energy gap from 3.27 eV to 3.75 eV as LASER fluence increased from 30 mJ/cm2 to 60 mJ/cm2. The average NPs core size distributions for the core-shell material ranged at ∼70 nm with the shell thickness around 20 nm. The biggest NPs were of ∼170 nm size which were sparsely distributed. The magnetization behaviors of the NPs were also investigated using the vibrating sample magnetometer (VSM). The NPs showed antimicrobial activities against the pathogenic species: Escherichia coli and Staphylococcus aureus. The antimicrobial activities of the synthesized NPs, synthesized under the influence of magnetic fields, were found to be more potent than the NPs synthesized without the presence of any magnetic field. The NPs prepared under the influence of the magnetic fields also comparatively exhibited higher levels of cytotoxicity against lung cancer cell lines (A549) than the NPs prepared under no magnetic field’s influence by the similar energy level effects of the LASER fluence. The flow cytometry analyses confirmed the NPs’ cytotoxic impacts against the human lung cancer A549 cell lines through the initiation of apoptosis and promotion of the cell cycle arrest at the G1 phase of cell division. To further confirm the cytotoxic effects and the mechanism of the anticancer activity of the synthesized NPs against the A549 cell lines, several related parameters (cell viability, membrane permeability, nuclear intensity, and cytochrome-C release) were analyzed using the high-content screening (HCS) assay. The study suggested that the prepared NPs have potential as antimicrobial and also as anti-lung-cancer agents as tested in vitro. These NPs can also be part of combined chemotherapy in different oncological interventions, as well as a sonosensitizer in sonomagnetic heating-based therapy, especially for cancers.

Optimization and chemical free fabrication of green synthesized iron nanoparticles as potential MRI contrast agent

“…The results are similar to research work reported by Neway Belachew et al 40 . and Hasan H. Bahjat et al 38 …”

“…However, the percentage of nanoparticles in 250 nm is very less, which may be due natural particle aggregation tendency of iron. There was evidence of both agglomerated and non‐agglomerated NP formation research work as reported by Hasan H. Bahjatet al 38 . Similar results on SEM analysis are also been reported by other workers 35 …”

“…From the S-shaped curve of Figure 5a,b, we can conclude that the synthesized nanoparticles INPs (raw INP sample) have the best super paramagnetic properties of the material than CCINPs (coated nanoparticle) (Figure 5b). The results are similar to research work reported by Neway Belachew et al 40 and Hasan H. Bahjat et al 38…”

One Pot Facile Bio-Synthesis of Anti-angiogenic Iron Oxide Nanoparticles Using the Bio-Reductant Sida spinosa

“…The in vivo data suggests that the iron oxide nanoparticle inhibits the growth of the cancer cells [47] effectively. The protein (albumin) supply for the growth of the cancer cells injected in the hatched egg yolk has been disrupted by the Fe2O3 nanoparticles effectively than the drug available commercially [48][49]. This fact evidently proves the anti-angiogenic capability of the Fe2O3 nanoparticles by the reduction in number of blood cells counted than that of the…”

Retracted: Preparation of Iron Oxide and Titania-Based Composite, Core-Shell Populated, Nanoparticulates Material by Two-Step LASER Ablation in Aqueous Media as Antimicrobial and Anticancer Agents

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”