One Pot Facile Bio-Synthesis of Anti-angiogenic Iron Oxide Nanoparticles Using the Bio-Reductant Sida spinosa

Abstract

Owing to the superior characteristics of the iron oxide nanoparticles Fe2O3 (SS-Fe) attracted a lot of attentions in various applications due to their unique physical and chemical properties. Moreover, due to their excellent surface area, compatible nano size spherical shape and ecofriendly synthesis route make them preferable and prudent in industrial and pharmacological applications. Based on this view, it aims to the bio-fabrication of iron oxide nanoparticles Fe2O3 (SS-Fe) by Sida spinosa extract as bio-reductant and stabilizing agent. The reports reveal that the nanoparticles have effective pharmacological applications. Highly economical and environmentally benign methodology supports the derivation of Fe2O3 (SS-Fe) nanoparticles in high yield. The SEM images reveals that, Fe2O3 (SS-Fe) nanoparticles possess spherical shape and the size of 81.72nm. The corresponding Fe-O band observed at 560.93 cm−1 indicates the formation of the nanoparticles. The EDX signals further confirms the nanoparticles by the peaks obtained for iron and oxygen atoms only. The absorbance peak at 374.00nm in UV-Visible spectrum evidently proves the synthesis of iron oxide nanoparticles. The λex = 645.18nm of the emission spectrum further supports the confirmation. The fabricated iron oxide nanoparticles show moderate antibacterial and a good antifungal efficacy. The iron oxide nanoparticles effectively inhibit the protein supply to the cancer cells which were injected to the egg yolk at 50µg/ml concentration gives 60.86% of inhibition.