Preparation of hydroxyapatite porous scaffold from a ‘coral-like’ synthetic inorganic precursor for use as a bone substitute and a drug delivery vehicle

Mohan, Nimmy; Palangadan, Rajesh; Fernandez, Francis Bonafice; Varma, H. K.

doi:10.1016/j.msec.2018.06.064

Cited by 30 publications

(9 citation statements)

References 31 publications

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“…Nanohydroxyapatite has been synthesized by functionalization with polyethylene glycol and folic acid, [103] using a micellar template combined with coprecipitation. [104,105,106] The antitumor epigenetic drug (EPI) was loaded into the folic acid-coupled, polyethylene glycol-coated nHAP (FA-PEG-nHAP) (Figure 4A). Folic acid is a low molecular targeted ligand that can be coated on the surface of nHAPs.…”

Section: Application Of Nhap Delivery Systems In Targeted Antitumor T...mentioning

confidence: 99%

The Janus Nature of Nanohydroxyapatite in Tumor Progression

Shen

Wan

et al. 2021

Adv Funct Materials

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Nanohydroxyapatite (nHAP) has broad applications because of its nanoscopical dimension, large specific surface area, biocompatibility, and low cytotoxicity. Researchers recently discovered that nHAP synthesized in vitro inhibits the growth of different types of tumor cells. Nanohydroxyapatite with potent drug adsorption and loading capacity has potential applications in tumor diagnosis and treatment. Because local tumors and areas of tumor metastasis also produce pathological nHAP in vivo to promote progression and invasion, the role of nHAP in tumorigenesis and development is perceived literature by many as Janus, the double‐faced deity in ancient Roman mythology. In the present review, two types of nHAP (those synthesized in vitro and those produced in vivo) that are affiliated with tumors, their mechanisms in tumor progression as well as their applications in tumor treatment are elucidated to create a backdrop for future research in this exciting, yet controversial arena.

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Section: Application Of Nhap Delivery Systems In Targeted Antitumor T...mentioning

confidence: 99%

The Janus Nature of Nanohydroxyapatite in Tumor Progression

Shen

Wan

et al. 2021

Adv Funct Materials

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“…In addition to this, CaCO 3 is also one of the possible calcium sources in the preparation of calcium phosphate materials such as hydroxyapatite [10,11], widely used for both environment remediation and bone replacement. In comparison with other calcium sources, the use of carbonate has the advantage that it is possible to obtain carbonated hydroxyapatite, which resembles more closely the composition of human bone and, therefore, shows improved biocompatibility [12].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic calcium carbonate with hierarchical porosity produced using cork as a sustainable template agent

Scalera

Carbone

Bettini

et al. 2020

Journal of Environmental Chemical Engineering

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“…Hydroxyapatite, a calcium phosphate based bioceramic materials found in natural bone is widely used as promising material for fixation of fractures and joint replacement due to its biocompatibility and bioactivity. 4 The HAP has been widely used in many of the clinical applications like bone repair, bone growth, and also widely used as coating material for metallic implants. Although there are different chemical methods available to synthesize HAP, 5,6,7,8,9,10,11 researchers still search for the facile, cheap, eco-friendly, and time saving method for the synthesis of bioactive HAP.…”

Section: Introductionmentioning

confidence: 99%

“…The combination of bioactive, mechanically stable, low cost composite materials necessary for the biomedical application is still under examination. Hydroxyapatite, a calcium phosphate based bioceramic materials found in natural bone is widely used as promising material for fixation of fractures and joint replacement due to its biocompatibility and bioactivity 4 . The HAP has been widely used in many of the clinical applications like bone repair, bone growth, and also widely used as coating material for metallic implants.…”

Section: Introductionmentioning

confidence: 99%

Biowaste‐derived hydroxyapatite reinforced with polyvinyl pyrrolidone/aloevera composite for biomedical applications

Mathina

Elangomannan

Kavitha

et al. 2020

Int J Applied Ceramic Tech

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The present investigation focuses on the synthesis of crabshell-derived hydroxyapatite (CS-HAP)/ water-soluble synthetic polymer-polyvinylpyrrolidone(PVP)/ aloevera(AV)-a natural biopolymer, as a composite for enhanced mechanical, antibacterial and biocompatible properties. The reinforcement of polymer has a significant function in increasing the mechanical property of the composite, whereas the incorporation of AV improves the antibacterial and biocompatibility. Phase composition, morphology, mechanical property, and hydrophilicity of CS-HAP/PVP/ AV biocomposite with different concentrations of PVP and AV were examined by Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray (SEM-EDX), Vickers microhardness tests, contact angle, respectively. Furthermore, the antibacterial efficiency of the composite is assessed using Escherichia coli (E coli) and Staphylococcus aureus (S aureus). The biocompatibility of HOS MG 63 cells on the CS-HAP/PVP/ AV composite is evaluated by MTT assay test. The obtained results evidence that the as-synthesized composite have appropriate mechanical, antibacterial and biocompatible properties. Overall, the combination of mechanical property of PVP, antibacterial and biocompatible property of AV in CS-HAP/PVP/AV, makes the composite a potential therapeutic material for various biomedical applications.

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Preparation of hydroxyapatite porous scaffold from a ‘coral-like’ synthetic inorganic precursor for use as a bone substitute and a drug delivery vehicle

Cited by 30 publications

References 31 publications

The Janus Nature of Nanohydroxyapatite in Tumor Progression

The Janus Nature of Nanohydroxyapatite in Tumor Progression

Biomimetic calcium carbonate with hierarchical porosity produced using cork as a sustainable template agent

Biowaste‐derived hydroxyapatite reinforced with polyvinyl pyrrolidone/aloevera composite for biomedical applications

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