Preparation of Hybrid Fe₃O₄/Poly(lactic‐co‐glycolic acid) (PLGA) Particles by Emulsion and Evaporation Method. Optimization of the Experimental Parameters

Abstract

Summary The incorporation of iron oxide nanoparticles into poly(lactic‐co‐glycolic) (PLGA) particles was carried out with an emulsion and evaporation method. To optimize the mean size and the particle size distribution of the particles, the following parameters were modulated: the molecular weight and the hydrolyzation degree of the surfactant, the concentration of the aqueous phase and the stirring rate. Samples were characterized by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS) and thermogravimetric analysis (TGA).

Fabrication of magnetic and fluorescent chitin and dibutyrylchitin sub-micron particles by oil-in-water emulsification

“…9), suggesting that the nanocrystals stabilize the particles. This effect has previously been observed before for PLGA particles prepared by emulsification technique [45], with the suggestion that iron oxide particles stabilize the emulsion by reducing the coalescence. This effect would be similar to the effect that particles exert on the Pickering emulsions [46].…”

PLGA-Based Nanoparticles in Cancer Treatment

“…The higher the concentration of polymer in the discontinuous phase, the larger the size of the resulting particles. This method aims at the incorporation of a wide range of drugs, as well as, contrast agents (i.e., iron oxides) or the co-encapsulation of both substances in one formulation ( Acharya and Sahoo, 2011 ; Lai et al, 2014 ; Mirakabad et al, 2014 ; Pérez et al, 2014 ; Shubhra et al, 2014 ). Despite the relatively poor loading of temozolomide in PLGA NPs, the single emulsion method performed best with respect to encapsulation efficiency compared with other preparation methods ( Ananta et al, 2016 ).…”

“…Despite the relatively poor loading of temozolomide in PLGA NPs, the single emulsion method performed best with respect to encapsulation efficiency compared with other preparation methods ( Ananta et al, 2016 ). The pitfall of this commonly used method is the presence of surfactant residues on the NPs surface even after several washing steps ( Pérez et al, 2014 ).…”