PLGA-Based Nanoparticles in Cancer Treatment

Abstract

Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently used in such setups. This review article gives an overview of the properties of previously reported PLGA nanoparticles (NPs), their behavior in biological systems, and their use for cancer therapy. Strategies are emphasized to target PLGA NPs to the tumor site passively and actively. Furthermore, combination therapies are introduced that enhance the accumulation of NPs and, thereby, their therapeutic efficacy. In this context, the huge number of reports on PLGA NPs used as drug delivery systems in cancer treatment highlight the potential of PLGA NPs as drug carriers for cancer therapeutics and encourage further translational research.

Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo

“…To the best of our knowledge, no similar drawbacks have been reported by using the biomaterials of our PLGA-basednanoparticles. The formulation used to deliver JQ1 in the present study, in addition to its high physical stability, is biocompatible and is made up of components already approved for human applications [34][35][36].…”

PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters

“…PLGA is successfully used in the research of drug delivery systems, because of its biodegradability and low systemic toxicity, it has also been approved by the US Food and Drug Administration (FDA) for medical applications. [8][9][10][11] PLGA can be formulated as PNP using several different methods, such as emulsicationevaporation, nanoprecipitation or solvent displacement, solvent diffusion, and phase-inversion; with sizes ranging from 10 to 1000 nm. 12,13 When encapsulating hydrophobic compounds, two of the most commonly used techniques are the emulsication-solvent evaporation technique and the nanoprecipitation technique.…”

Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications

“…(3) capable of producing both nanosystems or polymeric scaffolds; (4) chemically modifiable to include stealthing moieties (polyethylene glycol, PEG) and/or targeting ligands. All of these aspects have been widely exploited in production of PLGA nanoparticles (NPs) for the possible cure of a plethora of diseases [13][14][15][16][17][18].…”