Preparation of Glycy-l-Tyrosine intercalated layered double hydroxide film and its in vitro release behavior

Kong, Xianggui; Shi, Shuxian; Han, Jingbin; Zhu, Fengjie; Wei, Min; Duan, Xue

doi:10.1016/j.cej.2010.01.016

Cited by 42 publications

(20 citation statements)

References 36 publications

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“…The pseudo-first order kinetics mathematical model equation ln(q e − q t ) = lnq e − k 1 t (q e and q t are the equilibrium release amount and the release amount at time t, respectively), 17 the pseudo-second order equation t/q t = 1/k 2 q e 2 + t/q e 18 and the parabolic diffusion equation (1 − M t /M o )/t = kt −0.5 + b (M o and M t are the drug content that remained in LDH at the release times of 0 and t, respectively) 19 were used. alone, cell viability was reduced by more than 40% when the concentration of the hybrid exceeded 100 µg/mL.…”

Section: Surface Propertiesmentioning

confidence: 99%

Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent

Kura¹,

Ali²,

Hussein³

et al. 2013

IJN

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Abstract:A new layered organic-inorganic nanocomposite material with an anti-parkinsonian active compound, L-3-(3,4-dihydroxyphenyl) alanine (levodopa), intercalated into the inorganic interlayers of a Zn/Al-layered double hydroxide (LDH) was synthesized using a direct coprecipitation method. The resulting nanocomposite was composed of the organic moiety, levodopa, sandwiched between Zn/Al-LDH inorganic interlayers. The basal spacing of the resulting nanocomposite was 10.9 Å. The estimated loading of levodopa in the nanocomposite was approximately 16% (w/w). A Fourier transform infrared study showed that the absorption bands of the nanocomposite were characteristic of both levodopa and Zn/Al-LDH, which further confirmed intercalation, and that the intercalated organic moiety in the nanocomposite was more thermally stable than free levodopa. The resulting nanocomposite showed sustained-release properties, so can be used in a controlled-release formulation. Cytotoxicity analysis using an MTT assay also showed increased cell viability of 3T3 cells exposed to the newly synthesized nanocomposite compared with those exposed to pure levodopa after 72 hours of exposure.

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Section: Surface Propertiesmentioning

confidence: 99%

Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent

Kura¹,

Ali²,

Hussein³

et al. 2013

IJN

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“…42 The antihistamine activities of cetirizine, CETN, and ZLH were evaluated by determining their inhibitory potencies of histamine release in RBL-2H3 cells. Figure 10A-C illustrates the percentage of histamine release in RBL-2H3 cells when treated with cetirizine, CETN, and ZLH.…”

Section: Cytotoxicity Of Zlh and Cetn Nanomaterialsmentioning

confidence: 99%

Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells

Hasan¹,

Ali²,

Al‐Qubaisi³

et al. 2012

IJN

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Abstract:A controlled-release formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite "CETN," had a basal spacing of 33.9 Å, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The release study showed that about 96% of the guest could be released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC 50 for CETN and ZLH are 617 and 670 μg/mL, respectively.

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“…Therefore, it could be suggested that the results indicate the external surface diffusion or the intra particle diffusion via ion exchange which is the rate-determining step in the release process [25]. These results indicate that LDH and ZLH can be used to host a model guest, cloprop for their with controlled release properties.…”

Section: Kinetic Studymentioning

confidence: 86%

Synthesis and controlled release of cloprop herbicides from cloprop-layered double hydroxide and cloprop-zinc-layered hydroxide nanocomposites

Hashim¹,

Hussein²,

Isa³

et al. 2014

OJIC

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Two phenoxyherbicide nanocomposites, namely cloprop-layered double hydroxide and cloprop-zinclayered hydroxide nanocomposites, have been synthesized by using co-precipitation and direct reaction method. PXRD pattern showed an expansion of interlayer spacing with the value of 21.0 Å and 22.7 Å for cloprop-layered double hydroxide and cloprop-zinclayered hydroxide nanocomposite, respectively. It is evident from FTIR and elemental analyses that both nanocomposites were successfully intercalated between the interlayers of layered metal hydroxide. Controlled release of cloprop anion from interlayer of nanocomposites for both cloprop-layered double hydroxide and cloprop-zinc-layered hydroxide nanocomposite into phosphate solution was rapid initially and slow thereafter. The percentage of accumulated release of cloprop anion from cloprop-zinc-layered hydroxide nanocomposite was slightly higher than that from cloprop-layered double hydroxide nanocomposite. Kinetic behavior of cloprop release was governed by pseudo-second-order for cloprop-layered double hydroxide nanocomposite while parabolic diffusion for cloprop-zinc-layered hydroxide nanocomposite. Results from this study highlight the potential of both nanocomposites as capsulated material for controlled release of cloprop phenoxyherbicides anion.

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Preparation of Glycy-l-Tyrosine intercalated layered double hydroxide film and its in vitro release behavior

Cited by 42 publications

References 36 publications

Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent

Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent

Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells

Synthesis and controlled release of cloprop herbicides from cloprop-layered double hydroxide and cloprop-zinc-layered hydroxide nanocomposites

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