“…In order to construct a multifunctional dressing, we selected chitosan with hemostatic and antibacterial properties to make wound dressing. Chitosan, a derivative of chitin, the second rich polysaccharide in nature, possesses multiple properties, for instance, hemostasis, − antisepsis, , and anti-inflammatory, − promoting angiogenesis. , In addition, chitosan also has admirable physicochemical properties, , which can be used as an ideal carrier system for loading drugs such as cell growth factor − and hyaluronic acid. − In view of some inherent properties, chitosan has already been regarded as a potential material for biomedical applications. − Our previously work exhibited that hydroxybutyl chitosan (HBCS, chemical structure is shown in Scheme ) homogeneously synthesized in alkali/urea aqueous solutions was a brilliant wound dressing. Cytocompatibility studies, using normal human dermal fibroblast (NHDF) cells, demonstrated that HBCS was nontoxic, even promoting the growth of fibroblasts.…”