Preparation of Fluorescent Graphene Quantum Dots as Biological Imaging Marker for Cells

Xie, Wenjing; Fu, Yingyi; Ma, Hong; Zhang, Mo; Fan, Louzhen

doi:10.6023/a12060302

Cited by 17 publications

(9 citation statements)

References 14 publications

(14 reference statements)

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“…GQDs has been widely used for HeLa cells bioimaging 8a,9b,113,124. The feasibilities of GQDs for other tumor cells imaging including human breast cancer T47D cells,11b MCF‐7 cells, A549 cells, MG‐63 cells, MDA‐MB231, and so on have also been demonstrated. Chen et al prepared a pyrrole ring surface‐functionalized GQDs (p‐GQDs), [124a] which emitted strong bright yellow fluorescence after internalizing HeLa cells when excited on an inverted fluorescence microscope at 495 nm.…”

Section: Application In Bioimaging In Vitromentioning

confidence: 99%

Graphene Quantum Dots for Optical Bioimaging

Dong

et al. 2019

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Graphene quantum dots (GQDs) have shown great potential in bioimaging applications due to their excellent biocompatibility, low cytotoxicity, feasibility for surface functionalization, physiological stability, and tunable fluorescence properties. This Review first introduces the intriguing optical properties of GQDs that are suitable for biological imaging, and is followed by the GQDs' synthetic strategies. The emergent and latest development methods for tuning GQDs' optical properties are further described in detail. The recent advanced applications of GQDs in vitro, particularly in cell imaging, targeted imaging, and theranostic nanoplatform fabrication, are included. The applications of GQDs for in vivo bioimaging are also covered. Finally, the Review is concluded with the challenges and prospectives that face this nascent yet exciting field.

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Section: Application In Bioimaging In Vitromentioning

confidence: 99%

Graphene Quantum Dots for Optical Bioimaging

Dong

et al. 2019

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187

121

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“…碳荧光纳米材料由于具有荧光稳定性强、生物兼容性好、毒性低等特点, 在医药、生物技术领域的应用前景优于传统的有机荧光染料分子 [1] 、荧光蛋白和半导体量子点 [2] , 目前已经在细胞标记、成像 [3] 、诊断和药物传递 [4] 等方面显示出潜在的应用价值 [5~7] .…”

Section: 引言unclassified

Electrochemical Preparation of Color-Tunable Fluorescent Carbon Quantum Dots

Li¹,

Li²,

Lu³

et al. 2014

Acta Chim. Sinica

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“…一般来说, 碳材料尺寸分布较宽, 发光性质不仅受量子尺寸影响, 表面缺陷和边缘效应也产生了很大的影响 [5] . 所以碳材料在不同激发光激发下, 由于尺寸选择性或表面缺陷选择性, 呈现不同的发射光: 随着激发光红移, 发射光也呈现红移的趋势, 且强度降低 [7] , 但也有例外, 原因可能是不同的发光机理 [21] . [22] .…”

Section: 结果与讨论unclassified

Fluorescent Nanocomposite Based on PVA Polymer Dots

Zhu¹,

Zhang²,

Song³

et al. 2012

Acta Chim. Sinica

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Currently, fluorescent polymer dots (PDs) draw much attention these years in the fields of bioimaging and sensor due to their high fluorescence efficiency and extraordinary light-gathering capability. However, the present PDs are most conjugated polymer dots derived from conjugated polymer assembly. They preserve the advantages of conjugated polymer dots. Moreover, they are more stable than conjugated polymer and can be further functionalized for practical applications. The PDs in this article are prepared from non-conjugated linear polymer instead of conjugated polymer. Linear polymer is a kind of macromolecules composed of repeating non-conjugated structural units, such as polyethylene glycol (PEG), polysaccharides. These polymers show no fluorescence due to lack of photoluminescent centre. As a result, it is fancy to obtain fluorescent materials from this kind of "simple" polymers. Using carbonization method, photoluminescent polymer dots were prepared by moderately hydrothermal treating polyvinyl alcohol (PVA). PDs contain not only the fluorescent carbon center, but also the connected polymer chains. It's highly interesting to apply these PDs to polymer based fields using the outstanding properties of polymer chains. In this paper, derived from the fluorescent property and connected polymer chains of PDs, we investigated the functional nanocomposite based on PDs. Firstly, the polyvinyl alcohol (PVA)/PDs nanocomposite films were prepared (PDs was synthesized by carbonization of PVA). The nanocomposite films hold the fluorescent properties of PDs while it's also facile to be processed like the linear PVA, for example, nanocomposite films were prepared based on PDs, the proportion of PDs and PVA can be tuned as requirement from 0, 20%, 40%, 60%, 80%, 100%. The nanocomposite films have multi-color emission properties using different excitations due to the excitation-dependent behavior of PDs. Furthermore, other nanocomposites based on PDs were investigated such as PDs/water-solubility polymers, PDs/graphene quantum dots (GQDs) and PDs/semiconductor quantum dots. These nanocomposites have di-fluorescence property at the same excitation and could be used at sensor fields.

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Preparation of Fluorescent Graphene Quantum Dots as Biological Imaging Marker for Cells

Cited by 17 publications

References 14 publications

Graphene Quantum Dots for Optical Bioimaging

Graphene Quantum Dots for Optical Bioimaging

Electrochemical Preparation of Color-Tunable Fluorescent Carbon Quantum Dots

Fluorescent Nanocomposite Based on PVA Polymer Dots

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