Preparation of ferromagnetic microcapsules for hyperthermia using water/oil emulsion as a reaction field

Miyazaki, Toshiki; Miyaoka, Akira; Ishida, Eiichi; Li, Zhixia; Kawashita, Masakazu; Hiraoka, Masahiro

doi:10.1016/j.msec.2012.01.010

Cited by 20 publications

(8 citation statements)

References 21 publications

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“…However, the reason why their areas were not so different in spite that they had different content of Fe 3 O 4 is now under consideration. Although now we have no data about the heat generation of the PMMA microspheres without Fe 3 O 4 and even of the agar phantom, the amount of the heat generation of them might be negligible, since the change in temperature of a simple PMMA microsphere reported elsewhere 5) was less than 1 K within 600 s under the same alternating magnetic field.…”

Section: Magnetic Properties and In Vitro Heat Generation Of Microsphmentioning

confidence: 84%

Magnetite fine particles highly loaded PMMA microspheres for hyperthermia of deep-seated cancer

Shima

Kawai

Matsushima

et al. 2013

J. Ceram. Soc. Japan

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Poly(methyl methacrylate) (PMMA) microspheres several tens micrometers in diameter, containing highly dispersed sub-micron sized magnetite (Fe 3 O 4 ) particles, were successfully prepared via an emulsion polymerization process. Both oleic acid and sodium olate acted as suitable agents for high dispersion of the Fe 3 O 4 particles in the starting monomer solution (MMA). Spherical PMMA particles encapsulating 6572 mass % (3038 vol %) of the Fe 3 O 4 were obtained. The magnetic properties of the Fe 3 O 4 loaded PMMA microspheres depended on the amount of Fe 3 O 4 present in the resultant microspheres. The saturation magnetization and coercive force of the microspheres were 4963 emu·g ¹1 and 162170 Oe, respectively. The rate of an increase in temperature by heat generated from an agar phantom dispersed with a microsphere sample was 1 K·min ¹1 under an alternating magnetic field (100 kH, 300 Oe). This material is expected to be utilized as a thermal seed for hyperthermic treatment of deep-seated cancers in our bodies using a gap-type alternating current field apparatus in combination with a prospective drug delivery system.

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Section: Magnetic Properties and In Vitro Heat Generation Of Microsphmentioning

confidence: 84%

Magnetite fine particles highly loaded PMMA microspheres for hyperthermia of deep-seated cancer

Shima

Kawai

Matsushima

et al. 2013

J. Ceram. Soc. Japan

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“…Further details of this preparation technique and mechanism of the microsphere formation were described previously. 6…”

Section: Methodsmentioning

confidence: 99%

“…2,3 Implantation of ferromagnetic microspheres of 20–30 µm diameter into blood vessels around tumours facilitates the induction of more efficient hyperthermia combined with embolization to cut off the nutrient supply to the tumours. 4–7 This type of embolization therapy is especially effective for liver and kidney cancers. 8…”

Section: Introductionmentioning

confidence: 99%

Bisphosphonate release profiles from magnetite microspheres

et al. 2014

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Hyperthermia has been suggested as a novel, minimally invasive cancer treatment method. After implantation of magnetic nano- or microparticles around a tumour through blood vessels, irradiation with alternating magnetic fields facilitates the efficient in situ hyperthermia even for deep-seated tumours. On the basis of this idea, if the microspheres are capable of delivering drugs, they could be promising multifunctional biomaterials effective for chemotherapy as well as hyperthermia. In the present study, magnetite microspheres were prepared by aggregation of the iron oxide colloid in water-in-oil (W/O) emulsion. The release behaviour of alendronate, a typical bisphosphonate, from the microspheres was examined in vitro as a model of the bone tumour prevention and treatment system. The alendronate was successfully incorporated onto the porous magnetite microspheres in vacuum conditions. The drug-loaded microspheres maintained their original spherical shapes even after shaking in ultrapure water for 3 days, suggesting that they have sufficient mechanical integrity for clinical use. It was attributed to high aggregation capability of the magnetite nanoparticles through van der Waals and weak magnetic attractions. The microspheres showed slow release of the alendronate in vitro, resulting from tight covalent or ionic interaction between the magnetite and the alendronate. The release rate was diffusion-controlled type and well controlled by the alendronate concentration in drug incorporation to the microspheres.

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“…In a comparative study, 16 commercial magnetic fluids are investigated and most suitable ones are distinguished (Kallumadil et al, 2009). Magnetite microcapsules of 20-30 μm embedded in agar phantom exhibited heat generation under an alternating magnetic field (Miyazaki et al, 2012). Magnetite nanoparticles of 10 nm in an aerogel matrix are potential hyperthermia agents where the aerogel matrix can be used for drug loading for combined therapy (Lee et al, 2012).…”

Section: Hyperthermia Treatmentmentioning

confidence: 99%

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Bucak¹,

Yavuztürk²,

Sezer³

2012

Recent Advances in Novel Drug Carrier Systems

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Preparation of ferromagnetic microcapsules for hyperthermia using water/oil emulsion as a reaction field

Cited by 20 publications

References 21 publications

Magnetite fine particles highly loaded PMMA microspheres for hyperthermia of deep-seated cancer

Magnetite fine particles highly loaded PMMA microspheres for hyperthermia of deep-seated cancer

Bisphosphonate release profiles from magnetite microspheres

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

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