2020
DOI: 10.1039/c9sm01584a
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Preparation of electrospray ALG/PDA–PVP nanocomposites and their application in cancer therapy

Abstract: In this study, sodium alginate (ALG)/poly dopamine (PDA)–polyvinylpyrrolidone (PVP) nanocomposites was synthesized via a one-step electrostatic spraying method.

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Cited by 22 publications
(14 citation statements)
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“…Surgical resection would cause operative wounds, X-ray exposure may bring serious side effects to healthy tissue because of off-target [4,5], and chemotherapy usually shows limited efficacy with severe multi-drug resistance [6][7][8]. Thence, the malignant tumor is still posed as one of the greatest enemies of public health [9,10], and novel tumor therapeutic approaches to maximizing the treatment efficiency and minimizing the trauma to normal tissue were actively designed. Photon induced tumor therapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), has gained increasing interests in recent years.…”
Section: Introductionmentioning
confidence: 99%
“…Surgical resection would cause operative wounds, X-ray exposure may bring serious side effects to healthy tissue because of off-target [4,5], and chemotherapy usually shows limited efficacy with severe multi-drug resistance [6][7][8]. Thence, the malignant tumor is still posed as one of the greatest enemies of public health [9,10], and novel tumor therapeutic approaches to maximizing the treatment efficiency and minimizing the trauma to normal tissue were actively designed. Photon induced tumor therapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), has gained increasing interests in recent years.…”
Section: Introductionmentioning
confidence: 99%
“…20 Polyvinylpyrrolidone (PVP) is a kind of nonionic watersoluble polymer based on the polymerization of Nvinylpyrrolidone (NVP). [21][22][23] Hao et al 24 used UV oxidation to prepare poly-N-(vinyl) pyrrole nanoparticles (PNVPY NPs) when polyvinylpyrrolidone (PVP) was used as a soft template. A zinc-based anticorrosive coating was prepared by blending PNVPY with polyvinyl butyral (PVB) and it has excellent corrosion resistance owing to larger specific surface area and smaller size of PNVPY NPs.…”
Section: Introductionmentioning
confidence: 99%
“…The precursor is functionalized by the modified molecules 20 . Polyvinylpyrrolidone (PVP) is a kind of nonionic water‐soluble polymer based on the polymerization of N‐vinylpyrrolidone (NVP) 21–23 . Hao et al 24 used UV oxidation to prepare poly‐N‐(vinyl) pyrrole nanoparticles (PNVPY NPs) when polyvinylpyrrolidone (PVP) was used as a soft template.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, the PVP provides a new solution to enhance the biocompatibility of nanoparticles due to its good biosafety. [14] Although tumor cells show the enhanced permeability and retention effects, but smaller nanoparticles are easily recognized and quickly removed by the reticuloendothelial system (RES), which is difficult to accumulate in the tumor site, resulting an unsatisfactory therapeutic effect. [1b] The appropriate diameter of nanoparticles is a key factor to reach the tumor site actively or passively without being removed by RES.…”
Section: Introductionmentioning
confidence: 99%