NIR‐Responsive Fe₃O₄@MSN@PPy‐PVP Nanoparticles as the Nano‐Enzyme for Potential Tumor Therapy

Abstract

Among various kinds of photothermal conversion materials, polypyrrole (PPy) has attracted ever-increasing attention because of its good biocompatibility and excellent near-infrared light response property. In this research, the core-shell nanoparticles with magnetic Fe 3 O 4 as the core and mesoporous silica (MSN) as the shell were prepared, the resulted Fe 3 O 4 @MSN nanoparticles were then surface coated with a layer of PPy and further modified with polyvinylpyrrolidone (PVP) to gain colloidal stability. The Fe 2 + in Fe 3 O 4 can catalyze the decomposition of H 2 O 2 in tumor cells to produce cytotoxic hydroxyl radicals, thus realizing the tumor chemodynamic therapy. Meanwhile, the MSN layer gives the nanoparticles a higher drug loading capacity of chemotherapeutics (doxorubicin, DOX). Therefore, the prepared Fe 3 O 4 @MSN@PPy-PVP nanoparticles not only have good biocompatibility, magnetism and colloidal stability but also can realize the combined tumor photothermal, chemo, and chemodynamic therapy. This study demonstrates the rational design of multifunctional nanoplatforms for biomedical applications.

A NIR-II light-modulated injectable self-healing hydrogel for synergistic photothermal/chemodynamic/chemo-therapy of melanoma and wound healing promotion

“…S6, ESI †). It is observed that after the addition of GG@PANI(Fe), the o-phenanthroline (phen) molecules formed deep orange [Fe(phen) 3 ] 2+ complexes with a distinct characteristic peak at 510 nm, 49 indicating the existence of Fe 2+ ions in the GG@PANI(Fe) composite. Besides, according to the calculation by TG analysis (Fig.…”

Mesoporous silicas in materials engineering: Nanodevices for bionanotechnologies

“…Polypyrrole (PPy) is a promising photothermal agent for cancer therapy that has attracted increasing attention in the design of smart MSNs thanks to its good biocompatibility and excellent near-infrared light response property. Wang and collaborators [ 128 ] reported the polymerization of PPy on the external surface of magnetic Dox-loaded MSNs (Fe 3 O 4 @MSN@PPy-PVP@DOX). The obtained devices, in in vitro and in vivo experiments, showed a good inhibition of cancer cell growth due to the synergism of photothermal-, chemo- and chemodynamic therapy.…”

TLR-7/8 Agonist-Loaded Polypyrrole-Based Theranostic Nanovaccine for Second Near-Infrared Photothermal Immunotherapy of Cancer

“…The troubleshooting of this problem is done by grafting the nonionic surfactant poly(vinylpyrrolidone) (PVP) onto PPy NPs. 25 PVP is a polymer that offers a unique approach for enhancing the stability of NPs and is authorized by the Food and Drug Administration of the United States (U.S. FDA). 26 In addition, TAT peptide, a kind of nuclear localization signal (NLS), is an efficient molecule for translocating PPy into cell nuclei by interacting with receptors, i.e., importin α and β (karyopherin), further targeting nuclear pore complexes (NPCs), and finally entering the nuclei.…”

“…Moreover, pure PPy NPs have weak aqueous solubility, which limits their use in tumor PTT. The troubleshooting of this problem is done by grafting the nonionic surfactant poly­(vinylpyrrolidone) (PVP) onto PPy NPs . PVP is a polymer that offers a unique approach for enhancing the stability of NPs and is authorized by the Food and Drug Administration of the United States (U.S. FDA) .…”