Preparation of Core−Shell Structured PCL-r-Gelatin Bi-Component Nanofibers by Coaxial Electrospinning

Zhang, Yanzhong; Huang, Zheng‐Ming; Xu, Xiaojing; Lim, Chwee Teck; Ramakrishna, Seeram

doi:10.1021/cm049580f

Cited by 353 publications

(235 citation statements)

References 32 publications

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Section: −8mentioning

confidence: 99%

“…Moreover, inorganic−inorganic coaxial nanofibers were also fabricated by coelectrospinning of two different sol−gel systems. 22 On the other hand, polymer−polymer coaxial nanofibers have been extensively fabricated by using coaxial electrospinning setup 23,24 or they can also be obtained by single spinneret electrospinning of blends of the two different types of polymers.25 Yet, the fabrication of polymer−inorganic core−shell nanofibers is somewhat challenging because the deposition of inorganic shell layer requires a high temperature process that can easily deform the polymeric core structure.Recently, atomic layer deposition (ALD) technique has been explored to produce conformal and very thin inorganic coatings on fibrous systems such as cotton, 26,27 cellulose-based filter paper, 27−30 nonwovens, 26 synthetic 27,29 and natural fibers 31 and nanofibrillated cellulose 32 as well. ALD, which is a special type of low-temperature chemical vapor deposition, proceeds though the sequential pulses of two or more precursors separated by purging/evacuation periods.…”

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confidence: 99%

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Polymer–Inorganic Core–Shell Nanofibers by Electrospinning and Atomic Layer Deposition: Flexible Nylon–ZnO Core–Shell Nanofiber Mats and Their Photocatalytic Activity

Kayacı

Özgit-Akgün

Dönmez

et al. 2012

ACS Appl. Mater. Interfaces

149

122

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Polymer−inorganic core−shell nanofibers were produced by two-step approach; electrospinning and atomic layer deposition (ALD). First, nylon 6,6 (polymeric core) nanofibers were obtained by electrospinning, and then zinc oxide (ZnO) (inorganic shell) with precise thickness control was deposited onto electrospun nylon 6,6 nanofibers using ALD technique. The bead-free and uniform nylon 6,6 nanofibers having different average fiber diameters (∼80, ∼240 and ∼650 nm) were achieved by using two different solvent systems and polymer concentrations. ZnO layer about 90 nm, having uniform thickness around the fiber structure, was successfully deposited onto the nylon 6,6 nanofibers. Because of the low deposition temperature utilized (200°C ), ALD process did not deform the polymeric fiber structure, and highly conformal ZnO layer with precise thickness and composition over a large scale were accomplished regardless of the differences in fiber diameters. ZnO shell layer was found to have a polycrystalline nature with hexagonal wurtzite structure. The core−shell nylon 6,6-ZnO nanofiber mats were flexible because of the polymeric core component. Photocatalytic activity of the core−shell nylon 6,6-ZnO nanofiber mats were tested by following the photocatalytic decomposition of rhodamine-B dye. The nylon 6,6-ZnO nanofiber mat, having thinner fiber diameter, has shown better photocatalytic efficiency due to higher surface area of this sample. These nylon 6,6-ZnO nanofiber mats have also shown structural stability and kept their photocatalytic activity for the second cycle test. Our findings suggest that core−shell nylon 6,6-ZnO nanofiber mat can be a very good candidate as a filter material for water purification and organic waste treatment because of their photocatalytic properties along with structural flexibility and stability. KEYWORDS: electrospinning, ALD (atomic layer deposition), nanofibers, ZnO, core−shell, photocatalytic activity, nylon ■ INTRODUCTIONOne-dimensional (1D) nanostructures such as nanofibers have distinctive properties that can offer good opportunities for developing advanced materials and devices.1−3 Among the other nanofiber fabrication methods, electrospinning has gained growing interest in the past decade because this technique is quite versatile and cost-effective for producing functional nanofibers from variety of materials including polymers, polymer blends, emulsions, suspensions, sol−gels, metal oxides, composite structures as well as nonpolymeric systems, etc. 2−8Electrospun nanofibers and their nanofiber mats have remarkable characteristics including a very high specific surface area, pore sizes within the nanoscale and very lightweight since the fiber diameter ranges from one micrometer down to a few tens of nanometers. Moreover, the control of the fiber surface morphology, fiber orientation, and cross-sectional configuration, and design flexibility for physical/chemical modification is quite feasible for obtaining multifunctional electrospun nanofibers. Because of their exceptional pr...

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Section: −8mentioning

confidence: 99%

mentioning

confidence: 99%

Polymer–Inorganic Core–Shell Nanofibers by Electrospinning and Atomic Layer Deposition: Flexible Nylon–ZnO Core–Shell Nanofiber Mats and Their Photocatalytic Activity

Kayacı

Özgit-Akgün

Dönmez

et al. 2012

ACS Appl. Mater. Interfaces

149

122

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“…This membrane is suitable for use in tissue engineering, drug release and separation process [6]. Coaxial electrospinning is a modified electrospinning method which uses a blunt-tip coaxial needle to extrude core and shell solutions without mixing during electrospinning, thus producing nanofibers with a core/shell structure [7][8][9][10]. There are several advantages associated with the core/shell structure.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

et al. 2017

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It is difficult to fabricate chitosan-wrapped coaxial nanofibers, because highly viscous chitosan solutions might hinder the manufacturing process. To overcome this difficulty, our newly developed method, which included the addition of a small amount of gum arabic, was utilized to prepare much less viscous chitosan solutions. In this way, coaxial polyvinyl alcohol (PVA)/chitosan (as core/shell) nanofiber membranes were fabricated successfully by coaxial electrospinning. The core/shell structures were confirmed by TEM, and the existence of PVA and chitosan was also verified using FT-IR and TGA. The tensile strength of the nanofiber membranes was increased from 0.6-0.7 MPa to 0.8-0.9 MPa after being crosslinked with glutaraldehyde. The application potential of the PVA/chitosan nanofiber membranes was tested in drug release experiments by loading the core (PVA) with theophylline as a model drug. The use of the coaxial PVA/chitosan nanofiber membranes in drug release extended the release time of theophylline from 5 minutes to 24 hours. Further, the release mechanisms could be described by the Korsmeyer-Peppas model. In summary, by combining the advantages of PVA and chitosan (good mechanical strength and good biocompatibility respectively), the coaxial PVA/chitosan nanofiber membranes are potential biomaterials for various biomedical applications.

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“…It can be seen that in almost every fiber there was dark region outside of the light region. It was known that the nitrogen element in collagen could enhance the TEM contrast because of its higher conductivity, 17 which confirmed that the dark region as the sheath of the fiber is rich in collagen.…”

Section: ■ Results and Discussionmentioning

confidence: 85%

In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device

Guan

2013

Anal. Chem.

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In vivo analysis poses higher requirements about the biocompatibility, selectivity and speed of analytical method. In this study, an in vivo fast equilibrium microextraction method was developed with a biocompatible core− sheath electrospun nanofiber membrane sandwiched within a microfluidic unit. The polystyrene/collagen core−sheath nanofiber membrane was coaxially electrospun and strengthened with in situ glutaraldehyde cross-linking. This membrane not only kept high mass transfer rate, large extraction capacity and biomatrix resistance as our previously proposed membrane (Anal. Chem. 2013, 85 (12), 5924−5932), but also got much better mechanical strength and stability in water. The microfluidic device was designed to sandwich the membrane, and the blood in vivo can be introduced into it and get contact with the membrane repetitively. With this membrane and device, a 2-min equilibrium in vivo extraction method was established, validated in a simulated blood circulation system, and was used to monitor the pharmacokinetic profiles of desipramine in rabbits. The free and total concentration of desipramine in vivo was monitored with 10-min interval almost without rabbit blood consumed. The results met well with those of in vitro extraction, and a correlation factor of 0.99 was obtained.

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Preparation of Core−Shell Structured PCL-r-Gelatin Bi-Component Nanofibers by Coaxial Electrospinning

Cited by 353 publications

References 32 publications

Polymer–Inorganic Core–Shell Nanofibers by Electrospinning and Atomic Layer Deposition: Flexible Nylon–ZnO Core–Shell Nanofiber Mats and Their Photocatalytic Activity

Polymer–Inorganic Core–Shell Nanofibers by Electrospinning and Atomic Layer Deposition: Flexible Nylon–ZnO Core–Shell Nanofiber Mats and Their Photocatalytic Activity

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device

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