Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Kuo, Ting-Yun; Jhang, Cuei-Fang; Lin, Che-Min; Hsien, Tzu-Yang; Hsieh, Hsun-Ping

doi:10.1515/phys-2017-0125

Cited by 24 publications

(10 citation statements)

References 30 publications

(38 reference statements)

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“…The negative values of ∆E confirm the partial wetting regime as indicated in [63]. If considering the surface energy of pure water at 25 • C and γ L ≈ 0.72 J/m 2 , the pure gelatin or pure PVA γ S ≈ 0.033-0.29 J/m 2 [64][65][66] and then the interfacial γ SL = (γ S − γ L − ∆E) would be approximately (−0.0259-0.2311 J/m 2 ) and (−0.0146-0.2424 J/m 2 ). The negative values are physically infeasible as the interface between nanofibers and water becomes unstable.…”

supporting

confidence: 69%

Fabrication of Gelatin Nanofibers by Electrospinning—Mixture of Gelatin and Polyvinyl Alcohol

Chang

et al. 2022

Polymers

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Gelatin, one of the most abundant, naturally derived biomacromolecules from collagen, is widely applicable in food additives, cosmetic ingredients, drug formulation, and wound dressing based on their non-toxicity and biodegradability. In parallel, polyvinyl alcohol (PVA), a synthetic polymer, has been commonly applied as a thickening agent for coating processes in aqueous systems and a major component in healthcare products for cartilage replacements, eye lubrication, and contact lenses. In this study, a new type of mixed hydrogel nanofiber was fabricated from gelatin and polyvinyl alcohol by electrospinning under a feasible range of polymer compositions. To determine the optimal composition of gelatin and polyvinyl alcohol in nanofiber fabrication, several key physicochemical properties of mixed polymer solutions such as viscosity, surface tension, pH, and electrical conductance were thoroughly characterized by a viscometer, surface tensiometer, water analyzer, and carbon electron probe. Moreover, the molecular structures of polymeric chains within mixed hydrogel nanofibers were investigated with Fourier-transform infrared spectroscopy. The morphologies and surface elemental compositions of the mixed hydrogel nanofibers were examined by the scanning electron microscope and energy-dispersive X-ray spectroscopy, respectively. The measurement of water contact angles was performed for measuring the hydrophilicity of nanofiber surfaces. Most importantly, the potential cytotoxicity of the electrospun nanofibers was evaluated by the in vitro culture of 3T3 fibroblasts. Through our extensive study, it was found that a PVA-rich solution (a volumetric ratio of gelatin/polyvinyl alcohol <1) would be superior for the efficient production of mixed hydrogel nanofibers by electrospinning techniques. This result is due to the appropriate balance between the higher viscosity (~420–~4300 10−2 poise) and slightly lower surface tension (~35.12–~32.68 mN/m2) of the mixed polymer solution. The regression on the viscosity data also found a good fit by the Lederer–Rougier’s model for a binary mixture. For the hydrophilicity of nanofibers, the numerical analysis estimates that the value of interfacial energy for the water contact on nanofibers is around ~−0.028 to ~−0.059 J/m2.

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confidence: 69%

Fabrication of Gelatin Nanofibers by Electrospinning—Mixture of Gelatin and Polyvinyl Alcohol

Chang

et al. 2022

Polymers

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“…However, we found that these scaffolds quickly degrade in water-based media, providing only an immediate burst release of drugs. One of the approaches to overcome such challenges is the encapsulation of these gels by a hydrophobic shell polymer using coaxial electrospinning, which can also be used to generate hollow fibers 16,17,38 . A common hydrophobic polymer, polycaprolactone (PCL) is an aliphatic polyester that has been widely investigated for many biomedical applications, including wound healing, owing to its easy processability and biocompatibility 39,40 .…”

mentioning

confidence: 99%

Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds

Abudula¹,

Gauthaman

Mostafavi

et al. 2020

Sci Rep

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Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.

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“…and 2910 cm -1 for the stretching vibration of -CH 2 group, 1242, 1088, 1023 and 945 cm -1 (C-O) stretching vibration, respectively [41,48,49]. On the other hand, for the PVA-Gel bers the band appears at 3290 cm -1 for the (-OH) group.…”

Section: Ft-ir Analysismentioning

confidence: 94%

Folic acid-containing nanofibers by simultaneous process for transdermal drug delivery: preparation, characterization, and in vitro biocompatibility

Parın

Aydemir

Taner

et al. 2020

Preprint

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Nanofibers with bioactive agents are good candidates for skin-care applications due to high spesific surface area, low density and highly porous structure. In this study, hydrophilic based bioactive nanofibers were produced via an electrospinning and electrospraying simultaneous process. Polyvinyl alcohol (PVA), polyvinyl alcohol-gelatin (PVA-Gel) and polyvinyl alcohol-alginate (PVA-Alg) polymers were used as the matrix material and folic acid (FA) particles were dispersed simultaneously on the surface of these hydrophilic nanofibers. The morphology of the nanofibers (NFs) was uniform and dispersed folic acid particles incorporated into the structure of nanofibers as confirmed by scanning electron microscopy (SEM). Thermal behavior, chemical structure of the composite nanofibers were analyzed/investigated by thermogravimetric analysis (TGA) and Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR) which showed that no chemical bonding between vitamin and polymers. A controlled release of FA-loaded electrospun fibers were carried out by UV-Vis in vitro study within the 8 hour-period in artificial sweat solutions (acidic media, pH 5,44). The obtained PVA/FA, PVA-Gel/FA and PVA-Alg/FA fibers released 49.6 %, 69.55 % and 50.88 % of the sprayed FA in 8 h, indicating the influence of polymer matrix and polymer-drug interactions, on its release from the polymer matrix. Moreover, biocompatibility of all developed novel NFs was assessed by two different cytotoxicity tests,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and neutral red uptake (NRU) assay in L929 cell lines. In all cases, it is clearly concluded that these new electrospun fibers had fast-release of the vitamin and the hybrid process is suitable for transdermal patch applications, especially for skin-care products. Moreover, it has been proposed nanofiber with folic acid as a patch may prevent the COVID-19. The results of cytotoxicity assays on L929 cell reveal that all prepared NFs have no or slight cell toxicity. PVA and PVA-Gel with/without FA nanofibers seems more biocompatible than PVA-Alg nanofibers.

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Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Cited by 24 publications

References 30 publications

Fabrication of Gelatin Nanofibers by Electrospinning—Mixture of Gelatin and Polyvinyl Alcohol

Fabrication of Gelatin Nanofibers by Electrospinning—Mixture of Gelatin and Polyvinyl Alcohol

Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds

Folic acid-containing nanofibers by simultaneous process for transdermal drug delivery: preparation, characterization, and in vitro biocompatibility

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