“…Also, according to the particle size distribution histogram of KCC-1, the mean particle size diameter of KCC-1 prepared in this work is about 0.74 μm. Also, no considerable changes were observed in KCC-1 shape and particle size distribution after functionalization using amine groups 86 . Figure 1 FESEM images of ( a ) KCC-1 and ( b ) KCC-1-NH 2 .…”
In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.
“…Also, according to the particle size distribution histogram of KCC-1, the mean particle size diameter of KCC-1 prepared in this work is about 0.74 μm. Also, no considerable changes were observed in KCC-1 shape and particle size distribution after functionalization using amine groups 86 . Figure 1 FESEM images of ( a ) KCC-1 and ( b ) KCC-1-NH 2 .…”
In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.
“…groups Year (mg g −1 ) Conditions Ref. Cd(II) Pb(II) pH (min or h −1 ) (℃) LDH/MOF NC Soltani et al 2020 415.3 301.4 5.0 120 min 25 This work COOH-KCC-1/PA6 NC Soltani et al 2020 109.2 – 7.0 240 min 25 29 CSt-ZnO Naushad et al 2020 – 256.4 6.0 120 min 25 37 TATS@AC Naushad et al 2020 177.3 – 7.5 240 min 25 38 Cu-BTC MOF Hasankola et al 2019 – 333 5.0 25 min RT 39 Zn-BTC MOF – 312 ...…”
Section: Resultsmentioning
confidence: 96%
“…For this purpose, the influence of important adsorption parameters affecting the adsorption performance of the adsorbent was studied at room temperature ( = 25 ℃), including the effect of pH, adsorbent dose, initial metal concentration, and contact time. The heavy metal adsorption capacity on the adsorbent at equilibrium and any time t , as well as removal percentage, can be calculated using the following equations 29 : where and represent the uptake capacity of heavy metals at equilibrium (mg g −1 ) and any time (mg g −1 ), respectively. , , and are heavy metal concentration (mg g −1 ) at the initial stage (before adsorption), at equilibrium, and at any time , respectively.…”
To date, many nanoadsorbents have been developed and used to eliminate heavy metal contamination, however, one of the challenges ahead is the preparation of adsorbents from processes in which toxic organic solvents are used in the least possible amount. Herein, we have developed a new carboxylic acid-functionalized layered double hydroxide/metal–organic framework nanocomposite (LDH/MOF NC) using a simple, effective, and green in situ method. UiO-66-(Zr)-(COOH)2 MOF nanocrystals were grown uniformly over the whole surface of COOH-functionalized Ni50Co50-LDH ultrathin nanosheets in a green water system under a normal solvothermal condition at 100 °C. The synthesized LDH/MOF NC was used as a potential adsorbent for removal of toxic Cd(II) and Pb(II) from water and the influence of important factors on the adsorption process was monitored. Various non-linear isotherm and kinetic models were used to find plausible mechanisms involved in the adsorption, and it was found that the Langmuir and pseudo-first-order models show the best agreement with isotherm and kinetic data, respectively. The calculated maximum adsorption capacities of Cd(II) and Pb(II) by the LDH/MOF NC were found to be 415.3 and 301.4 mg g−1, respectively, based on the Langmuir model (pH = 5.0, adsorbent dose = 0.02 g, solution volume = 20 mL, contact time = 120 min, temperature = 25 ℃, shaking speed 200 rpm).
“…MC‐FDU‐12/poly(methyl methacrylate) nanocomposite (MC‐FDU‐12/PMMA NC) and DA‐FDU‐12/polyamide 6 nanocomposite (DA‐FDU‐12/PA6 NC) were prepared according to the synthesis procedures described by Soltani and his colleagues 27, 29.…”
Section: Methodsmentioning
confidence: 99%
“…In recent years, the design and development of MSMs/polymer nanocomposites have been a solution to this problem that despite increasing the particle size of the nanocomposite adsorbents, one can add the advantages of the polymer such as ductility and cheaper price to the composite adsorbent. Recently, Soltani and his colleagues synthesized a variety of MSMs/polymer matrix nanocomposites, such as amino‐modified MCM‐41/polyvinyl alcohol 26, KCC‐1/chitosan‐oleic acid 4, and carbocyclic acid‐functionalized KCC‐1/polyamide 6 27 as adsorbent materials and used them for removal of heavy metals from water.…”
Large‐pore mesoporous silica FDU‐12 was synthesized and functionalized with silane coupling agents bearing methacrylate and diamino groups. Diamino‐functionalized FDU‐12/polyamide 6 and methacrylate‐functionalized FDU‐12/poly(methyl methacrylate) nanocomposites were prepared via in situ polymerization approach. These two synthesized nanocomposites were used as potential adsorbents for the removal of Cd2+ cations from aqueous media. The impact of different adsorption factors affecting the adsorption process was investigated, and isotherm and kinetic studies were conducted to gain a better understanding of adsorption mechanisms involved in the removal process of Cd2+ by the adsorbents. Experimental and computational results demonstrated that the adsorbents have acceptable performance for Cd2+ uptake.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
