Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets

Abstract

In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.

Antioxidant activity and controlled‐release feature of Quercetin loaded amines‐functionalized magnetically porous cellulose

“…45 Marjani and co-worker also demonstrated a better controlled-release capability of amines-functionalized KCC1 toward quercetin compared to microcrystalline cellulose tablets. 46 Another investigation also proved that the addition of amine functional group on the surface of drugs carrier considerably improves both quercetin drug loading capacity and release behavior which are highly recommended for pharmaceutical manufacturing. 47,48 Therefore, in order to improve our drug carrier performance, a surface modification to introduce amines functional group was carried out.…”

“…Zhao et al modified the surface of cellulose nanofibril aerogel by grafting poly(ethyleneimine) exhibiting a high loading capacity of water‐soluble sodium salicylate by 287.39 mg/g and having sustained and controlled release behavior over pH and temperature stimuli 45 . Marjani and co ‐worker also demonstrated a better controlled‐release capability of amines‐functionalized KCC1 toward quercetin compared to microcrystalline cellulose tablets 46 . Another investigation also proved that the addition of amine functional group on the surface of drugs carrier considerably improves both quercetin drug loading capacity and release behavior which are highly recommended for pharmaceutical manufacturing 47,48 .…”

Amine and Sulfonic Acid Anchored Porous Silica as Recyclable Heterogeneous Catalysts for Ring‐Opening of Oxiranes

“…[19] There are also some reports on amine modified silica as host on drug controlled-release rate, post-combustion CO 2 capture. [25][26] Amine-functionalized MOF-177 has also been used for enhancing the CO 2 capture capacity. [27] Amine functionalized SBA-15 has been used in the hydrogenation of CO 2 to formic acid, reusing and activity for CO 2 cycloaddition onto oxiranes.…”

“…on synthesis and application of amine and aldehyde modified mesoporous silica for enhanced lipase immobilization, biodiesel production, and their separation [19] . There are also some reports on amine modified silica as host on drug controlled‐release rate, post‐combustion CO 2 capture [25–26] . Amine‐functionalized MOF‐177 has also been used for enhancing the CO 2 capture capacity [27] .…”

“…There are many reports of organic functionalization on mesoporous silica and a variety of functional groups such as carboxyl, [17] zwitterion, [18] aldehyde, [19] sulphonic acid, [20] Brönsted acid, [21] Lewis acid, [22] enzyme, [23] (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), [24] amine, [25][26] etc. that have been extensively used for different applications.…”