Preparation of Carrier-Free Vanadium, Scandium, and Arsenic Activities from Cyclotron Targets by Ion Exchange

Schindewolf, U.; Irvine, John W.

doi:10.1021/ac60137a011

Cited by 40 publications

(10 citation statements)

References 8 publications

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“…Some methods based on distillation of GeCl 4 are reported whereas arsenic was kept in the non-volatile form of As(V) [22] followed by solvent extraction [23,24], cation exchange [25] or anion exchange [26]. Schindewolf and Irvine [27] absorbed Ge and Ga from diluted HF solutions on anion exchange resin AG1X8 while As(III) was not absorbed. Some more data about the behaviour of As(V) in HF media [28] and mixtures of HF/HNO 3 media [29] on AG1X8 are available although data for Ga differ in [27] and [28].…”

Section: Separationsmentioning

confidence: 99%

“…Schindewolf and Irvine [27] absorbed Ge and Ga from diluted HF solutions on anion exchange resin AG1X8 while As(III) was not absorbed. Some more data about the behaviour of As(V) in HF media [28] and mixtures of HF/HNO 3 media [29] on AG1X8 are available although data for Ga differ in [27] and [28]. The behaviour of Ge, As(III) and As(V) in HCl media on AG1X8 is very well known from literature [30][31][32] and some data about the absorption in HCl/acetone media are available [33].…”

Section: Separationsmentioning

confidence: 99%

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Separation and purification of no-carrier-added arsenic from bulk amounts of germanium for use in radiopharmaceutical labelling

et al. 2010

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72 As, 74 As, 77 As / Radioactive arsenic / Germanium target / Radiochemical separation / Labelled antibodies Summary. Radioarsenic labelled radiopharmaceuticals could add special features to molecular imaging with positron emission tomography (PET). For example the long physical half-lives of 72 As (T 1/2 = 26 h) and 74 As (T 1/2 = 17.8 d) in conjunction with their high positron branching rates of 88% and 29%, respectively, allow the investigation of slow physiological or metabolical processes, like the enrichment and biodistribution of monoclonal antibodies in tumour tissue or the characterization of stem cell trafficking. A method for separation and purification of no-carrier-added (nca) arsenic from irradiated metallic germanium targets based on distillation and anion exchange is developed. It finally converts the arsenic into an * As(III) synthon in PBS buffer and pH 7 suitable for labelling of proteins via As−S bond formations. The method delivers radioarsenic in high purity with separation factors of 10 6 from germanium and an overall yield from target to labelling synthon of > 40%. In a proof-ofprinciple experiment, the monoclonal antibody Bevacizumab, directed against the human VEGF receptor, was labelled with a radiochemical yield > 90% within 1 h at room temperature with nca 72/74/77 As.

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Section: Separationsmentioning

confidence: 99%

Section: Separationsmentioning

confidence: 99%

Separation and purification of no-carrier-added arsenic from bulk amounts of germanium for use in radiopharmaceutical labelling

et al. 2010

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“…The method for carrier-free vanadium separation was based on the retention of scandium and other impurities by anion exchange resin in hydrofluoric medium [29][30][31]. Briefly, the experimental procedure was: approximately 30 mg of the irradiated Li 2 TiO 3 were dissolved with 1.5 ml conc.…”

Section: Peak Identification and Radiochemical Separationmentioning

confidence: 99%

Production of 48V in a nuclear reactor via secondary tritons

Siri¹,

Cohen

2009

Radiochimica Acta

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The production of 48 V in a nuclear reactor, induced on titanium by tritons generated from the 6 Li(n, t) 4 He reaction, and eventually 7 Li(n, n t) 4 He, is described. Samples of lithium titanate were irradiated for an irradiation cycle (120 h) in the RA-3 reactor, belonging to Ezeiza Atomic Centre. After a radiochemical separation, the characteristic radiations from 48 V were identified in the gamma ray spectra of the vanadium fractions.

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“…This requires efficient radiochemical separation of 77 As from large amounts of Ge target material. In the past few years, there have been considerable efforts towards development of effective separation techniques involving distillation, co-precipitation, solvent extraction, thin layer chromatography, etc., for the isolation of 77 As from cyclotron or reactor irradiated germanium or germanium oxide targets [13][14][15][16][17][18][19][20][21][22][23].…”

mentioning

confidence: 99%

Polymer Embedded Nanocrystalline Titania: A New Generation Sorbent for the Separation of 77As from Ge for Biomedical Applications

et al. 2011

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The present work demonstrates the utility of polymer embedded nanocrystalline titania (TiP) as a new, accessible and viable solid sorbent for the chromatographic separation of high specific activity 77 As from neutron irradiated natural GeO 2 . Experimental parameters such as distribution ratios (K d ), equilibrium sorption capacity, breakthrough capacity and separation yields were determined. A two-step ion-exchange procedure was developed to avail 77 As, from irradiated Ge in alkaline medium. The first step involved removal of the bulk Ge from 77 As by selective sorption of Ge ions on a TiP column at pH 13. Subsequently, the effluent solution containing 77 As was further purified and concentrated by sorption on a small TiP column at pH 10. 77 As could be eluted from the second column in 2-3 mL of 0.1 M NaOH solution with[80% radiochemical yield. The 77 As obtained by this method was found to have insignificantly small level of radiocontaminants.

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Preparation of Carrier-Free Vanadium, Scandium, and Arsenic Activities from Cyclotron Targets by Ion Exchange

Cited by 40 publications

References 8 publications

Separation and purification of no-carrier-added arsenic from bulk amounts of germanium for use in radiopharmaceutical labelling

Separation and purification of no-carrier-added arsenic from bulk amounts of germanium for use in radiopharmaceutical labelling

Production of 48V in a nuclear reactor via secondary tritons

Polymer Embedded Nanocrystalline Titania: A New Generation Sorbent for the Separation of 77As from Ge for Biomedical Applications

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