Preparation of carbon nanotubes and polyhedral oligomeric-reinforced molecularly imprinted polymer composites for drug delivery of gallic acid

Zhang, Xue; An, Dong-Yu; Zhang, Rongrong; Huang, Yanping; Liu, Zhao‐Sheng

doi:10.1016/j.ijpharm.2022.121476

Cited by 21 publications

(6 citation statements)

References 29 publications

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“…171,172 Several studies have demonstrated the potential use of MIPs for the delivery of chemical drugs or other therapeutic agents in biomedical applications. [173][174][175] It is worth applying different modifications or inventions to the MIPs for different needs. Using MIPs as novel shells to encapsulate BDs or directly stitching BDs as part of the MIPs into a more stereospecific polymer cocktail will broaden the utility of synthesis methods and the application types.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods

Xiangxun

Dau

et al. 2023

Biomater. Sci.

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Section: Biomaterials Science Reviewmentioning

confidence: 99%

Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods

Xiangxun

Dau

et al. 2023

Biomater. Sci.

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“…Therefore, these properties of GA pose challenges in achieving sustained therapeutic levels of the compound in pharmaceutical approaches. To overcome these limitations, several procedures, including drug delivery systems such as niosomes [12,15,[20][21][22], have been proposed to encapsulate GA, protecting it from degradation and facilitating its targeted delivery to specific sites in the body [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Span 60/Cholesterol Niosomal Formulation as a Suitable Vehicle for Gallic Acid Delivery with Potent In Vitro Antibacterial, Antimelanoma, and Anti-Tyrosinase Activity

Zolghadri,

Asad,

Farzi

et al. 2023

Pharmaceuticals

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Natural compounds such as gallic acid (GA) have attracted more attention in cosmetic and pharmaceutical skin care products. However, the low solubility and poor stability of GA have limited its application. This study aimed to synthesize and characterize the GA niosomal dispersion (GAN) and investigate the potential of an optimal formulation as a skin drug delivery system for GA. For this purpose, GAN formulations were synthesized using the thin layer evaporation method with different molar ratios of Tween 60/Span 60, along with a constant molar ratio of polyethylene glycol 4000 (PEG-4000) and cholesterol in a methanol and chloroform solvent (1:4 v/v). The physicochemical properties of nanosystems in terms of size, zeta potential, drug entrapment, drug release, morphology, and system–drug interaction were characterized using different methods. In addition, in vitro cytotoxicity, anti-tyrosinase activity, and antibacterial activity were evaluated by MTT assay, the spectrophotometric method, and micro-well dilution assay. All formulations revealed a size of 80–276 nm, polydispersity index (PDI) values below 0.35, and zeta potential values below—9.7 mV. F2 was selected as the optimal formulation due to its smaller size and high stability. The optimal formulation of GAN (F2) was as follows: a 1:1 molar ratio of Span 60 to cholesterol and 1.5 mM GA. The release of the F2 drug showed a biphasic pattern, which was fast in the first 12 h until 58% was released. Our results showed the high antibacterial activity of GAN against Escherichia coli and Pseudomonas aeruginosa. The MTT assay showed that GA encapsulation increased its effect on B6F10 cancer cells. The F2 formulation exhibited potent anti-tyrosinase activity and inhibited melanin synthesis. These findings suggest that it can be used in dermatological skin care products in the cosmetic and pharmaceutical industries due to its significant antibacterial, anti-melanoma, and anti-tyrosinase activity.

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“…Molecularly imprinted materials (MIMs) have a wide range of potential applications due to their ability to selectively bind to and recognize specific target molecules. This includes extraction, isolation, purification, catalysis, and antibody simulation [1]. The use of MIMs in sustained-release drug delivery is an active area of research and development, and there is still much to be investigated about their potential in this field.…”

Section: Introductionmentioning

confidence: 99%

Development of an Fe3O4 Surface-Grafted Carboxymethyl Chitosan Molecularly Imprinted Polymer for Specific Recognition and Sustained Release of Salidroside

Qiu

et al. 2023

Polymers

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The choice of carrier material is critical in the study of natural drug release preparations and glycosylated magnetic molecularly imprinted materials. The stiffness and softness of the carrier material affect the efficiency of drug release and the specificity of recognition. The dual adjustable aperture-ligand in molecularly imprinted polymers (MIPs) provides the possibility of individualized design for sustained release studies. In this study, a combination of paramagnetic Fe3O4 and carboxymethyl chitosan (CC) was used to enhance the imprinting effect and improve drug delivery. A combination of tetrahydrofuran and ethylene glycol was used as a binary porogen to prepare MIP-doped Fe3O4-grafted CC (SMCMIP). Salidroside serves as the template, methacrylic acid acts as the functional monomer, and ethylene glycol dimethacrylate (EGDMA) serves as the crosslinker. Scanning and transmission electron microscopy were used to observe the micromorphology of the microspheres. The structural and morphological parameters of the SMCMIP composites were measured, including the surface area and pore diameter distribution. In an in vitro study, we found that the SMCMIP composite had a sustained release property of 50% after 6 h of release time in comparison to the control SMCNIP. The total amounts of SMCMIP released at 25 °C and 37 °C were 77% and 86%, respectively. In vitro results showed that the release of SMCMIP followed Fickian kinetics, meaning that the rate of release is dependent on the concentration gradient, with diffusion coefficients ranging from 3.07 × 10−2 cm2/s to 5.66 × 10−3 cm2/s. The results of cytotoxicity experiments showed that the SMCMIP composite did not have any harmful effects on cell growth. The survival rates of intestinal epithelial cells (IPEC-J2) were found to be above 98%. By using the SMCMIP composite, drugs may be delivered in a sustained manner, potentially leading to improved therapeutic outcomes and reduced side effects.

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Preparation of carbon nanotubes and polyhedral oligomeric-reinforced molecularly imprinted polymer composites for drug delivery of gallic acid

Cited by 21 publications

References 29 publications

Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods

Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods

Span 60/Cholesterol Niosomal Formulation as a Suitable Vehicle for Gallic Acid Delivery with Potent In Vitro Antibacterial, Antimelanoma, and Anti-Tyrosinase Activity

Development of an Fe3O4 Surface-Grafted Carboxymethyl Chitosan Molecularly Imprinted Polymer for Specific Recognition and Sustained Release of Salidroside

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