Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods

Xiangxun, Chen; Wu, Yuao; Dau, Van Thanh; Nguyen, Nam‐Trung; Ta, Hang T.

doi:10.1039/d2bm01594c

Cited by 5 publications

(4 citation statements)

References 188 publications

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“…Represented with permission. [97] the assembly using chemical methods), 2) biodistribution issues, and 3) pharmacokinetics. [104] The surface functionalization of AuNPs with chemical functional groups or biological molecules like drugs and therapeutic agents (e.g., DNA, miRNA, siRNA, antibodies, and peptides) allows targeted drug delivery and high stability and biocompatibility in vivo.…”

Section: Gold Nps (Aunps)mentioning

confidence: 99%

“…Nanotheranostic platforms are prepared using various methods such as sonication (ultrasonication), emulsification (single‐phase or double‐phase), extrusion/co‐extrusion, electroporation/microfluidic electroporation, nanoprecipitation, self‐encapsulation, coaxial electrospraying, and so on. According to recent research, [ 97 ] in single‐phase emulsification, two different (i.e., aqueous and organic) phases are dispersed (by sonication or stirring) to form a semi‐stable mixture containing core‐shell structures. The aqueous phase contains therapeutics (or drug‐loading NPs), while the organic phase is composed of polymers (e.g., PLGA, PEG‐PLGA, etc.)…”

Section: Recent Progress In Nanotheranostics and Nps‐based Drug Deliverymentioning

confidence: 99%

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Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Beygi,

Oroojalian,

Azizi‐Arani

et al. 2024

Adv Funct Materials

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The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent junctions that regulates the transport of various materials and substances between the blood vasculature and the central nervous system (CNS). However, in cases of brain diseases, BBB's protective and regulatory effects hamper therapeutics from reaching affected sites in sufficient quantities. This has so far been a leading challenge in treating CNS diseases and disorders. For this problem to be overcome, recent research has sought to develop novel modalities to achieve efficient therapy and alleviate associated symptoms. Therefore, numerous strategies have operated in recent years to address the limitations of traditional and invasive methods, including poor brain penetration and serious side effects. As a desperately in‐demand technology, nanotheranostics has particularly shown promising results. Herein, this review reports recent advancements in CNS nanotheranostics and novel techniques and nanotechnology‐based strategies developed for treating neurodegenerative disorders. The study provides comprehensive data on the subject to be used for future studies for the therapy and management of CNS disorders and diseases.

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Section: Gold Nps (Aunps)mentioning

confidence: 99%

Section: Recent Progress In Nanotheranostics and Nps‐based Drug Deliverymentioning

confidence: 99%

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Beygi,

Oroojalian,

Azizi‐Arani

et al. 2024

Adv Funct Materials

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“…This proof-of-concept data provide a good example for future studies to exploit PSI-OA for loading BDs while preserving BD activity. Furthermore, previously reported studies have employed nanoprecipitation method to load BDs such as lysozyme, αchymotrypsin, amylase, trypsin inhibitor and catalase and their activity was retained [72]. However, these studies utilised various stabilisers such as polyvinyl acetate (PVA) during synthesis to avoid aggregation of the NPs and support NP formation during the nanoprecipitation process [38,53,54,73,74].…”

Section: In Vitro Bd Activitymentioning

confidence: 99%

Preparation of protein-loaded nanoparticles based on poly(succinimide)-oleylamine for sustained protein release: a two-step nanoprecipitation method

Chen,

Moonshi,

Nguyen

et al. 2023

Nanotechnology

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Currently, the treatment for acute disease encompasses the use of various biological drugs (BDs). However, the utilisation of BDs is limited due to its rapid clearance and non-specific accumulation in unwanted sites which results in a lack of therapeutic efficacy accompanied with adverse effects. While nanoparticles were considered a good candidate to resolve this problem, some available polymeric carriers for these BDs are mainly designed for long-term sustained release. Thus, there is a need to explore new polymeric carriers for diseases’ acute phase that requires sustained release of BDs in a short period such as thrombolysis and infec-tion. Poly(succinimide)-oleylamine (PSI-OA), a biocompatible polymer with tuneable dissolu-tion profile, represents a promising strategy to load BD for sustained release within a 48-hour period. In this work, we developed a two-step nanoprecipitation method to load the model protein (e.g. bovine serum albumin (BSA) and lipase) with PSI-OA. The characteristics of the nanoparticles were assessed based on various loading parameters, such as concentration, stir-ring rate, flow rate, volume ratios, dissolution, and the release of the protein. The optimised NPs displayed a size within 200 nm that is suitable for vasculature delivery to the target sites. These findings suggest that PSI-OA can be employed as a carrier for BDs for applications that require sustained release in a short period.

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“…Therefore, in order to enhance the therapeutic efficiency of the formulation, appropriate therapeutic agents could be loaded into the NPs. Several investigations have been conducted on the biodegradability of nanomaterials in a biological milieu, demonstrating promising outcomes for instance in terms of therapeutic efficacy and release profiles (e.g., erosion-based release mechanisms). − Curcumin (Cur), a natural polyphenolic compound, has been established as a promising drug in a variety of diseases. , Cur has powerful anti-inflammatory, antioxidant, and anticalcification properties; however, its clinical application is hindered by several drawbacks, including low aqueous solubility and rapid metabolism . Cur loading into PSI NPs not only addresses these limitations but also enables targeting of delivery of Cur to the disease site.…”

Section: Introductionmentioning

confidence: 99%

A Bioactive Disintegrable Polymer Nanoparticle for Synergistic Vascular Anticalcification

Adelnia,

Moonshi,

et al. 2023

ACS Nano

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Although poly(aspartic acid) (PASP), a strong calcium chelating agent, may be potentially effective in inhibition of vascular calcification, its direct administration may lead to side effects. In this study, we employed polysuccinimide, a precursor of PASP, to prepare targeted polysuccinimide-based nanoparticles (PSI NPs) that not only acted as a prodrug but also functioned as a carrier of additional therapeutics to provide powerful synergistic vascular anticalcification effect. This paper shows that chemically modified PSI-NPs can serve as effective nanocarriers for loading of hydrophobic drugs, in addition to anticalcification and antireactive oxygen species (anti-ROS) activities. Curcumin (Cur), with high loading efficiency, was encapsulated into the NPs. The NPs were stable for 16 h in physiological conditions and then slowly dissolved/hydrolyzed to release the therapeutic PASP and the encapsulated drug. The drug release profile was found to be in good agreement with the NP dissolution profile such that complete release occurred after 48 h at physiological conditions. However, under acidic conditions, the NPs were stable, and Cur cumulative release reached only 30% after 1 week. Though highly effective in the prevention of calcium deposition, PSI NPs could not prevent the osteogenic trans-differentiation of vascular smooth muscle cells (VSMCs). The presence of Cur addressed this problem. It not only further reduced ROS level in macrophages but also prevented osteogenic differentiation of VSMCs in vitro. The NPs were examined in vivo in a rat model of vascular calcification induced by kidney failure through an adenine diet. The inclusion of Cur and PSI NPs combined the therapeutic effects of both. Cur-loaded NPs significantly reduced calcium deposition in the aorta without adversely affecting bone integrity or noticeable side effects/toxicity as examined by organ histological and serum biochemistry analyses.

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Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods

Abstract: Biological drugs (BDs) play an increasingly irreplaceable role in treating various diseases such as cancer, cardiovascular, and neurodegenerative diseases. The market share of BDs is increasingly promising. However, the effectiveness...

Cited by 5 publications

References 188 publications

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Preparation of protein-loaded nanoparticles based on poly(succinimide)-oleylamine for sustained protein release: a two-step nanoprecipitation method

A Bioactive Disintegrable Polymer Nanoparticle for Synergistic Vascular Anticalcification

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