Preparation of biocompatible microsphere-cryogel composite system and controlled release of mupirocin

Yavuz, Burcu; Solak, Ebru Kondolot; Oktar, Ceren

doi:10.1080/00914037.2022.2163638

Cited by 5 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Composite Cryogels for Sustained Drug Delivery: References [ 85 , 86 ] address the development of cryogels for sustained drug delivery. Reference [ 85 ] proposes nanocomposite cryogels for sustained topical delivery of hydrophobic natural substances such as cannabidiol (CBD).…”

Section: Natural Polysaccharidesmentioning

confidence: 99%

“…It compares the sustained release profiles achieved by nanocomposite cryogels with those of pure 2-hydroxyethyl cellulose (HEC) cryogel carriers, demonstrating the superior performance of the nanocomposite cryogels. Reference [ 86 ] focuses on the preparation of PVP/NaCMC microspheres loaded with the antibiotic Mupirocin (MP). The study investigates various parameters affecting drug release and achieves an optimized drug release profile in a microsphere-cryogel composite system.…”

Section: Natural Polysaccharidesmentioning

confidence: 99%

“…Moreover, cryogels have been explored for gene delivery, cartilage tissue regeneration, and as drug delivery systems for cancer treatment and water purification [ 69 , 109 , 110 , 111 ]. They have demonstrated characteristics such as improved encapsulation efficiency, sustained release profiles, enhanced drug solubility, and controlled release behavior, making them suitable for a wide range of therapeutic applications [ 22 , 23 , 24 , 25 , 84 , 85 , 86 , 87 , 88 , 90 , 92 , 93 , 94 , 95 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ].…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

“…Controlled release of antibiotic Mupirocin [86] Enzymatically modified starch cryogels Carriers of active molecules for drug delivery systems and potential applications in biomedical and food packaging scenarios [154] Composite cryogels (OPS or OWS with DMAEM) fabrication of semi-IPN cryogels using PVA cryogel with thermochromic ink Thermochromic material for temperature estimation in ultrasound therapy [91] PVA cryogel…”

Section: Polysaccharides and Their Hybrids-based Cryogelmentioning

confidence: 99%

See 3 more Smart Citations

Cryogels: Advancing Biomaterials for Transformative Biomedical Applications

2023

View full text Add to dashboard Cite

Cryogels, composed of synthetic and natural materials, have emerged as versatile biomaterials with applications in tissue engineering, controlled drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties, such as mechanical strength and release profiles, remains challenging. To advance the field, researchers are exploring advanced manufacturing techniques, biomimetic design, and addressing long-term stability. Combination therapies and drug delivery systems using cryogels show promise. In vivo evaluation and clinical trials are crucial for safety and efficacy. Overcoming practical challenges, including scalability, structural integrity, mass transfer constraints, biocompatibility, seamless integration, and cost-effectiveness, is essential. By addressing these challenges, cryogels can transform biomedical applications with innovative biomaterials.

show abstract

Section: Natural Polysaccharidesmentioning

confidence: 99%

Section: Natural Polysaccharidesmentioning

confidence: 99%

Section: Challenges and Perspectivesmentioning

confidence: 99%

Section: Polysaccharides and Their Hybrids-based Cryogelmentioning

confidence: 99%

See 2 more Smart Citations

Cryogels: Advancing Biomaterials for Transformative Biomedical Applications

2023

View full text Add to dashboard Cite

show abstract

“…To address bacterial infections in wounds using cryogels, researchers have traditionally added antibiotics to create antibacterial cryogels. 15,16 However, this approach has drawbacks, including the risk of antibiotic resistance. 17,18 Eventually, it is predicted by World Health Organization that about 10 million people will die of antimicrobial resistance each by 2050.…”

Section: Introductionmentioning

confidence: 99%

Alginate Cryogels for Rapid Hemostasis and Toluidine Blue-Mediated Photodynamic Inactivation of Bacteria

Lin,

Chen,

Xia

et al. 2024

ACS Omega

View full text Add to dashboard Cite

The development of new wound dressings with fast hemostatic and bactericidal properties for prehospital care is critical. Antibacterial photodynamic therapy (aPDT) has attracted attention due to its broad-spectrum antibacterial activity and minimal bacterial resistance. However, photosensitizers used in aPDT often face issues such as poor water solubility, short-lived singlet oxygen ( 1 O 2 ), and limited 1 O 2 diffusion range. In this study, sodium alginate was covalently modified with the photosensitizer toluidine blue O (TBO) and phenylboronic acid (PBA). The modified alginate was then cross-linked with Ca(II) ions and lyophilized to form a cryogel, named SA@Ca(II)@TBO@PBA (SCTP). This cryogel functions as an antibacterial photodynamic wound dressing. The chemical immobilization of TBO and PBA enhanced the cryogel's targeting ability. PBA formed reversible covalent bonds with diol groups on bacterial cell surfaces, allowing the cryogel to capture bacteria effectively and enhance aPDT. The bactericidal efficiency of the cryogel was tested through in vitro antibacterial assays, and its hemostatic properties were confirmed in vivo. The results indicate that this cryogel has excellent hemostatic and antibacterial capabilities, showing great promise as a wound dressing for clinical applications.

show abstract