Preparation of bioactive glass ceramic nanoparticles by combination of sol–gel and coprecipitation method

Hong, Zhongkui; Liu, Aixue; Chen, Li; Chen, Xuesi; Jing, Xiabin

doi:10.1016/j.jnoncrysol.2008.12.003

Cited by 97 publications

(55 citation statements)

References 34 publications

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“…thin films or particles, are highly porous exhibiting a high specific surface area [10,40,46]. Recent work on fabricating bioactive silicate glass nanoparticles by sol-gel process has been carried out by Hong et al [47]. In their research, nanoscale bioactive glass particles were obtained by the combination of two steps; sol-gel route and coprecipitation method, wherein the mixture of precursors was hydrolyzed in acidic environment and condensed in alkaline condition separately, and then followed by a freeze-drying process.…”

Section: Sol-gel Techniquesmentioning

confidence: 99%

“…In their research, nanoscale bioactive glass particles were obtained by the combination of two steps; sol-gel route and coprecipitation method, wherein the mixture of precursors was hydrolyzed in acidic environment and condensed in alkaline condition separately, and then followed by a freeze-drying process. A schematic diagram about the improved sol-gel synthesis process developed by Hong et al [42,47] is presented in Figure 1. The morphology and size of bioactive glass nanoparticles could be tailored by varying the production conditions and the feeding ratio of reagents [48,49].…”

Section: Sol-gel Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Boccaccını

Erol

Stark

et al. 2010

Composites Science and Technology

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287

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The physico-chemical, mechanical, and biological advantages of incorporating nanoscale bioactive glasses in such biodegradable nanocomposites are discussed and the possibilities to expand the use of these materials in other nanotechnology concepts aimed to be used in different biomedical applications are also highlighted. ACCEPTED MANUSCRIPT

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Section: Sol-gel Techniquesmentioning

confidence: 99%

Section: Sol-gel Techniquesmentioning

confidence: 99%

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Boccaccını

Erol

Stark

et al. 2010

Composites Science and Technology

Self Cite

460

287

View full text Add to dashboard Cite

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“…Several groups have attempted to incorporate calcium into silica nanoparticles by using a two-step sol-gel process in which precursors of silica and calcium (TEOS and calcium nitrate respectively) are hydrolysed in an acidic solution before gelation under alkaline conditions [24][25][26][27][28]. While EDX data showed calcium was present in the particles [25] and they induced HCA formation in simulated body fluid (SBF), little or no quantitative analysis was performed on the final elemental composition.…”

Section: Introductionmentioning

confidence: 99%

“…However, despite being spherical and dispersed, the resulting particles did not show a homogeneous size distribution even after optimisation of the polymer:TEOS ratio. Some papers have attempted to improve the dispersion or shape of the nanoparticles by use of a surfactant [25,28]. However, this can inhibit calcium diffusion, therefore limiting the amount of calcium that enters the glass [1].…”

Section: Introductionmentioning

confidence: 99%

Controlling particle size in the Stöber process and incorporation of calcium

Greasley

Page

Sirovica

et al. 2016

Journal of Colloid and Interface Science

141

152

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The Stӧber process is commonly used for synthesising spherical silica particles. This article reports the first comprehensive study of how the process variables can be used to obtain monodispersed particles of specific size. The modal particle size could be selected within in the range 20 -500 nm. There is great therapeutic potential for bioactive glass nanoparticles, as they can be internalised within cells and perform sustained delivery of active ions. Biodegradable bioactive glass nanoparticles are also used in nanocomposites. Modification of the Stӧber process so that the particles can contain cations such as calcium, while maintaining monodispersity, is desirable. Here, while calcium incorporation is achieved, with a homogenous distribution, careful characterisation shows that much of the calcium is not incorporated. A maximum of 10 mol% CaO can be achieved and previous reports are likely to have overestimated the amount of calcium incorporated.

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“…The sol-gel method which was an alternative route proposed for bioactive glass synthesis by Li et al [14] has several advantages and minimizes the limitations of the melt-quenching route. The method has better versatility compared to the melt-quenching technique and requires much lower processing temperatures [15][16][17][18]. The sol-gel bioactive glasses have nano-porosity which results in better cellular response and a better surface area hence better biodissolution.…”

Section: Introductionmentioning

confidence: 99%

Sol–gel synthesis and in vitro bioactivity of glass–ceramics in SiO2–CaO–Na2O–P2O5 system

Thomas

Bera

2016

J Sol-Gel Sci Technol

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Bioactive glass-ceramic powder in SiO 2 -CaONa 2 O-P 2 O 5 system was successfully synthesised through a modified sol-gel route. The gel was prepared using tetraethyl orthosilicate, calcium nitrate, sodium nitrate and triethyl phosphate raw materials. The gel was calcined in the temperature range 700-1050°C to get the glass-ceramic powder. Dissolution of the glass-ceramic powder was studied by in vitro immersion in Tris buffer solution for various period of time. The biodegraded powder was analyzed using XRD. The sintered glass-ceramic was characterized for in vitro bioactivity in simulated body fluid, and the incubated pellet was then analyzed for phase identification by XRD, surface morphology using SEM and elemental analysis using energy-dispersive X-ray analysis. The biocompatibility of the glass-ceramics was evaluated through MTT assay using MG-63 cells. Graphical Abstract

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Preparation of bioactive glass ceramic nanoparticles by combination of sol–gel and coprecipitation method

Cited by 97 publications

References 34 publications

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Controlling particle size in the Stöber process and incorporation of calcium

Sol–gel synthesis and in vitro bioactivity of glass–ceramics in SiO2–CaO–Na2O–P2O5 system

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