Bioactive glass-ceramic powder in SiO 2 -CaONa 2 O-P 2 O 5 system was successfully synthesised through a modified sol-gel route. The gel was prepared using tetraethyl orthosilicate, calcium nitrate, sodium nitrate and triethyl phosphate raw materials. The gel was calcined in the temperature range 700-1050°C to get the glass-ceramic powder. Dissolution of the glass-ceramic powder was studied by in vitro immersion in Tris buffer solution for various period of time. The biodegraded powder was analyzed using XRD. The sintered glass-ceramic was characterized for in vitro bioactivity in simulated body fluid, and the incubated pellet was then analyzed for phase identification by XRD, surface morphology using SEM and elemental analysis using energy-dispersive X-ray analysis. The biocompatibility of the glass-ceramics was evaluated through MTT assay using MG-63 cells.
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