Preparation of Binapacryl Suspension Concentrates and Their Physical Stability

Fujimoto, Masahiko; Nakamura, Toshiie; Muraoka, Etsuko

doi:10.1584/jpestics.7.499

Cited by 3 publications

(2 citation statements)

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“…By covering the surface of the nanoparticles, the surfactant molecules could shield the inner compound, decrease the free energy of the particles and reduce interfacial tension [ 55 , 56 ]. In addition, the polymeric structure of emulsifier 700 affords steric protection from agglomeration and prevents crystal growth [ 57 , 58 , 59 ]. As a result, particle size growth fluctuates little.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Evaluation of Lambda-Cyhalothrin Nanosuspension by One-Step Melt Emulsification Technique

et al. 2019

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Recent years have witnessed significant progress in nanotechnology and pesticide research in pest control and crop protection. There are more motivations to develop nanoformulations that are less harmful to environment than conventional formulations. The use of nanosuspension has been proposed as a novel formulation to process poorly soluble pesticides. In this study, the lambda-cyhalothrin nanosuspension (LCNS) was prepared in a melt emulsification method. The prepared nanosuspension had a mean particle size of 12.0 ± 0.1 nm and a polydispersity index of 0.279 ± 0.135. The smaller particle size and polydispersity confer better wettability, stability and bioavailability than conventional suspension concentrates. The excellent properties of the nanosuspension were attributed to the reduced particle size and the emulsification and dispersion of the surfactants. The LCNS eliminates the need for organic solvents and significantly reduces the amount of surfactant required. The simple production process of LCNS saves production and equipment costs. The results indicate that lambda-cyhalothrin nanosuspensions would have a broad application prospect in agricultural production systems.

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Section: Resultsmentioning

confidence: 99%

Fabrication and Evaluation of Lambda-Cyhalothrin Nanosuspension by One-Step Melt Emulsification Technique

et al. 2019

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“…Eye-drops have a simpler application method than eye ointments and involve minor discomfort when applied. In contrast, suspension formulations are associated with problems such as the growth of dispersed particles, and thus, an increase in particle diameter during storage affects the biological activity [ 2 ]. It is also reported that the aggregates adhere to the containers.…”

Section: Introductionmentioning

confidence: 99%

Effect of storage temperature on the dispersibility of commercially available 0.1% fluorometholone ophthalmic suspension

et al. 2022

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In this study, we focused on the storage conditions and investigated the effects of low-temperature storage (10°C) on the dispersibility of active components in three formulations of fluorometholone (FLU) suspension eye-drops (one original drug and two generic drugs, P1-P3). For all three eye-drop products, before shaking by hand, white sediment anticipated to be the principal active component was seen at the vial base. In the ordinary-temperature storage group, the FLU contents per drop after shaking by hand were 0.076% in P1, 0.023% in P2, and 0.100% in P3, and the content in P2 was significantly lower than that in P1 and P3. In contrast, almost no dispersion was observed in the low-temperature group. The results after sufficient shaking of these samples with a vortex, in contrast, were such that the FLU contents per drop were 0.063% in P1, 0.086% in P2, and 0.088% in P3; the content in P1 was significantly lower than that in P2 and P3, and there was no difference between P2 and P3. Moreover, we evaluated the dispersibility according to the evaluation “Vs / (ρg − ρf) g.” In both the low- and ordinary-temperature storage groups, the value of Vs / (ρg − ρf) g, proportional to the terminal velocity, decreased in the following order: P3 > P1 ≫ P2, and each value in the ordinary-temperature was higher than that in low temperature. The zeta potential decreased in the following order: P2 > P3 ≫ P1. In conclusion, when FLU suspension eye drops are stored at low temperatures until use, such as in a refrigerator, ordinary shaking does not help achieve dispersion to the specified concentration, and even with vigorous shaking with some formulations, the specified concentration cannot be achieved.

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Effect of Shelf Life on the Physical Stability of Suspended Ophthalmic Solutions

et al. 2021

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Preparation of Binapacryl Suspension Concentrates and Their Physical Stability

Cited by 3 publications

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Fabrication and Evaluation of Lambda-Cyhalothrin Nanosuspension by One-Step Melt Emulsification Technique

Fabrication and Evaluation of Lambda-Cyhalothrin Nanosuspension by One-Step Melt Emulsification Technique

Effect of storage temperature on the dispersibility of commercially available 0.1% fluorometholone ophthalmic suspension

Effect of Shelf Life on the Physical Stability of Suspended Ophthalmic Solutions

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