Preparation of agglomerated crystals for improving flowability and compactibility of poorly flowable and compactible drugs and excipients

Improvement of physicochemical and biopharmaceutical properties of flurbiprofen using melt sonocrystallization technique

“…According to the literature, smaller values of the constant a indicated higher packability, and the higher value of the constant b indicated less resistance to compression. In other words, smaller a and higher b values indicated good flowability and reduced cohesiveness [Guo et al, 2002;Nokhodchi et al, 2007]. From the current results, treated FBP showed a lower value of constant a and higher value for constant b, as compared with untreated FBP, i.e., it achieved the final packing state quickly and had smaller cohesiveness and better flowability.…”

Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer

“…The spherical agglomeration consists of crystallization of fine crystals of a drug followed by the aggregation by employing water -immiscible solvents (e.g., methylene chloride or chloroform, as binder liquid. 4,5 Nonetheless, in case of using these solvents, they can increase ecological and human safety worries over solvents left in the samples, thus they are not suggested for the routine production process. Conversely, QESD is built on the miscibility of solvents with water.…”

Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles

“…Many methods to improve the flowability of cohesive powders are based on controlled agglomeration or by coating of polymer films (Nokhodchi et al, 2007;Bajdik et al, 2004). A recent method that is effective and simple for improving the flowability of powders (Ramlakhan et al, 2000;Yang et al, 2005) is based on surface modification via dry coating, where the surface of the cohesive drug particles (host) is coated with small amount of nano-sized particles (guest).…”