Preparation of Acyclovir-Containing Solid Foam by Ultrasonic Batch Technology

Abstract

In recent years, the application of solid foams has become widespread. Solid foams are not only used in the aerospace field but also in everyday life. Although foams are promising dosage forms in the pharmaceutical industry, their usage is not prevalent due to decreased stability of the solid foam structure. These special dosage forms can result in increased bioavailability of drugs. Low-density floating formulations can also increase the gastric residence time of drugs; therefore, drug release will be sustained. Our aim was to produce a stable floating formula by foaming. Matrix components, PEG 4000 and stearic acid type 50, were selected with the criteria of low gastric irritation, a melting range below 70 °C, and well-known use in oral drug formulations. This matrix was melted at 54 °C in order to produce a dispersion of active substance and was foamed by different gases at atmospheric pressure using an ultrasonic homogenizer. The density of the molded solid foam was studied by the pycnometer method, and its structure was investigated by SEM and micro-CT. The prolonged drug release and mucoadhesive properties were proved in a pH 1.2 buffer. According to our experiments, a stable foam could be produced by rapid homogenization (less than 1 min) without any surfactant material.

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

“…The matrix of this DF was formed by a porous mass of a solidified mixture of PEG 4000 and stearic acid. The foam obtained in this way had mucoadhesive properties, ensuring the absence of a rise delay, and flotation during the release in accordance with the zero-order kinetics model within 10 h [68].…”

Új típusú gyógyszerformula minőségfejlesztése

“…Az előállítótt szilárd habót megszárítótták, hógy méretét jelentősen csökkentsék, így könnyen adagólhatóvá vált. Eddigi kutatásaink szerint gyórs (1 percnél rövidebb) hómógenizálással stabil habót lehetett előállítani felületaktív anyag nélkül [23] [24] [25].…”

“…A végfelhasználói vélemények nagyón fontosok, mind gazdasági, mind technólógiai szempóntból, mivel csak a termék használója tudja valójában, hógy miért is egyedi, értékes a termék és mennyit is ér számára. Szakiródalómban ismertetett cikkek és fógyasztói tanulmányók[23] [24][25] alapján olyan követelményeket határóztunk meg, amelyek egy elnyújtótt hatóanyagleadású (retard) gyógyszerkészítmény fejlesztésével kapcsólatban relevánsak lehetnek. Az igényeket az 1. táblázatban fóglaltuk össze.Az előző fejezetben a VoC elemzés segítségével meghatárózásra kerültek azón vevői igények, amelyek fontosok lehetnek egy új retard gyógyszerkészítmény fejlesztésénél.…”

Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model

“…To increase stomach residence time, different technological methods, including swelling and expansion, mucoadhesive, high density, ion exchange, magnetic, and floating drug delivery systems, are employed [ 16 ]. Floating beads, low-density drug delivery systems, can float in the gastric fluids, allow the solubility of the drug in the acidic medium of the stomach, and hence improve its bioavailability [ 17 ].…”