Six different theoretical equations are compared in the present paper with experimental data, measured for 28 binary liquid metallic systems. General conclusions are drawn on the ability of the different theoretical models to describe the concentration and temperature dependence of the viscosity of liquid alloys. A new equation is derived, being able to predict the viscosity in multicomponents alloy even if the viscosities of the pure components are not known.

Dosage forms with increased gastric residence time are promising tools to increase bioavailability of drugs with narrow absorption window. Low-density floating formulations could avoid gastric emptying; therefore, sustained drug release can be achieved. Our aim was to develop a new technology to produce low-density floating formulations by melt foaming. Excipients were selected carefully, with the criteria of low gastric irritation, melting range below 70°C and well-known use in oral drug formulations. PEG 4000, Labrasol and stearic acid type 50 were used to create metronidazole dispersion which was foamed by air on atmospheric pressure using in-house developed apparatus at 53°C. Stearic acid was necessary to improve the foamability of the molten dispersion. Additionally, it reduced matrix erosion, thus prolonging drug dissolution and preserving hardness of the moulded foam. Labrasol as a liquid solubiliser can be used to increase drug release rate and drug solubility. Based on the SEM images, metronidazole in the molten foam remained in crystalline form. MicroCT scans with the electron microscopic images revealed that the foam has a closed-cell structure, where spherical voids have smooth inner wall, they are randomly dispersed, while adjacent voids often interconnected with each other. Drug release from all compositions followed Korsmeyer-Peppas kinetic model. Erosion of the matrix was the main mechanism of the release of metronidazole. Texture analysis confirmed that stearic acid plays a key role in preserving the integrity of the matrix during dissolution in acidic buffer. The technology creates low density and solid matrix system with micronsized air-filled voids.

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The development of an efficient procedure for 3d modeling and finite element simulation of metal foams is one of the greatest challenges for engineer researchers nowadays. Creating 3d CAD model is alone a demanding engineering task due to its extremely complex geometry, and the proper finite element analysis process is still in the center of the research. The increasingly widespread application of the metal foams, e.g. in vehicle and medical industry, requires this knowledge in the design phase. A closed-cell metal foam is studied using different analyzing methods where the aim is to collect information about the composition and geometry (structure) that is satisfactory for the later research. Using statistical methods microscopic, X-ray and surface analyzing studies on the specimens produced according to the concerning standard are evaluated. The main goal of this part of the project is to obtain structural information and to determine the homogeneity or the in-homogeneity property of the metal foam specimens taken from different locations.

Nowadays, besides the use of conventional insulations (plastic foams and wool materials), aerogels are one of the most promising thermal insulation materials. As one of the lightest solid materials available today, aerogels are manufactured through the combination of a polymer with a solvent, forming a gel. For buildings, the fiber-reinforced types are mainly used. In this paper, the changes both in the thermal performance and the material structure of the aerogel blanket are followed after thermal annealing. The samples are put under isothermal heat treatments at 70 °C for weeks, as well as at higher temperatures (up to 210 °C) for one day. The changes in the sorption properties that result from the annealing are presented. Furthermore, the changes in the thermal conductivity are followed by a Holometrix Lambda heat flow meter. The changes in the structure and surface of the material due to the heat treatment are investigated by X-ray diffraction and with scanning electron microscopy. Besides, the above-mentioned measurement results of differential scanning calorimetry experiments are also presented. As a result of using equipment from different laboratories that support each other, we found that the samples go through structural changes after undergoing thermal annealing. We manifested that the aerogel granules separate down from the glass fibers and grow up. This phenomenon might be responsible for the change in the thermal conductivity of the samples.

Numerous organizations are striving to maximize the profit of their businesses by the effective implementation of competitive advantages including cost reduction, quick delivery, and unique high-quality products. Effective production-scheduling techniques are methods that many firms use to attain these competitive advantages. Implementing scheduling techniques in high-mix low-volume (HMLV) manufacturing industries, especially in Industry 4.0 environments, remains a challenge, as the properties of both parts and processes are dynamically changing. As a reaction to these challenges in HMLV Industry 4.0 manufacturing, a newly advanced and effective real-time production-scheduling decision-support system model was developed. The developed model was implemented with the use of robotic process automation (RPA), and it comprises a hybrid of different advanced scheduling techniques obtained as the result of analytical-hierarchy-process (AHP) analysis. The aim of this research was to develop a method to minimize the total production process time (total make span) by considering the results of risk analysis of HMLV manufacturing in Industry 4.0 environments. The new method is the combination of multi-broker (MB) optimization and a genetics algorithm (GA) that uses general key process indicators (KPIs) that are easy to measure in any kind of production. The new MB–GA method is compatible with industry 4.0 environments, so it is easy to implement. Furthermore, MB–GA deals with potential risk during production, so it can provide more accurate results. On the basis of survey results, 16% of the asked companies could easily use the new scheduling method, and 43.2% of the companies could use it after a little modification of production.

The aim of this paper is to review all the existing literature models on the concentration dependence of the viscosity of binary liquid alloys and to check them against the measured viscosity values in the binary liquid Cu-Ag system at 1373K.

One of the most promising emerging innovations in personalized medication is based on 3D printing technology. For use as authorized medications, 3D-printed products require different in vitro tests, including dissolution and biocompatibility investigations. Our objective was to manufacture implantable drug delivery systems using fused deposition modeling, and in vitro tests were performed for the assessment of these products. Polylactic acid, antibacterial polylactic acid, polyethylene terephthalate glycol, and poly(methyl methacrylate) filaments were selected, and samples with 16, 19, or 22 mm diameters and 0%, 5%, 10%, or 15% infill percentages were produced. The dissolution test was performed by a USP dissolution apparatus 1. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide dye (MTT)-based prolonged cytotoxicity test was performed on Caco-2 cells to certify the cytocompatibility properties. The implantable drug delivery systems were characterized by thermogravimetric and heatflow assay, contact angle measurement, scanning electron microscopy, microcomputed tomography, and Raman spectroscopy. Based on our results, it can be stated that the samples are considered nontoxic. The dissolution profiles are influenced by the material properties of the polymers, the diameter, and the infill percentage. Our results confirm the potential of fused deposition modeling (FDM) 3D printing for the manufacturing of different implantable drug delivery systems in personalized medicine and may be applied during surgical interventions.